DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d2 and Cyp4a31

DIOPT Version :9

Sequence 1:	NP_001284806.1	Gene:	Cyp4d2 / 31192	FlyBaseID:	FBgn0011576	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_964002.2	Gene:	Cyp4a31 / 666168	MGIID:	3028580	Length:	509	Species:	Mus musculus

Alignment Length:	481	Identity:	159/481 - (33%)
Similarity:	262/481 - (54%)	Gaps:	63/481 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 LYRVWILHQLAVFSTDP-------------RDIEFVLS---------------SQQHIT------ 98
            |:|.|:|..|..|.:.|             ::::.::|               |:.::|
Mouse    39 LHRKWLLKALQQFPSPPFHWFFGHEQFKGDQELQEIVSCIENFPSAFPRWFWGSKAYLTVYDPDY 103

  Fly    99 -----------KNNLYKLLNCWLGDGLLMSTGRKWHGRRKIITPTFHFKILEQFVEIFDQQSAVM 152
                       .|..|:||..|:|.|||:..|:.|...||::||.||:.||:.:|:.......:|
Mouse   104 MKVILGRSDPKANGAYRLLAPWIGYGLLLLNGQSWFQHRKMLTPAFHYDILKTYVKNMADSIRLM 168

  Fly   153 VEQLQSRADGMTPINIFPVICLTALDIIAETAMGTKINAQKNPNL-PYVQAVNDVTNILIKRFIH 216
            :::.:..|...:.|.||..|.|..||.:.:.|...|.:.|.:.|. .|:||:.|:.|::..|..:
Mouse   169 LDKWERLAGQDSSIEIFQHISLMTLDTVMKCAFSHKGSVQVDGNYKTYLQAIGDLNNLVHSRVRN 233

  Fly   217 AWQRVDWIFRLTQPTEAKRQDKAIKVMHDFTENIIRERRETLVNNSKETTPEEEVNFLGQKRRMA 281
            .:.:.|.|::|:  :..:..::|.::.||.|:.:|:.|::.|.:       |.|:..:.:|||:.
Mouse   234 MFHQNDTIYKLS--SNGRLSNQACQLAHDHTDGVIKMRKDQLQD-------EGELENIKKKRRLD 289

  Fly   282 LLDVLLQSTIDGA-PLSDEDIREEVDTFMFEGHDTTTSAISFCLYEISRHPEVQQRLQQEIRDVL 345
            .||:||.:.::.. .:||:|:|.||||||.||||||.|.:|:..|.::.|||.|||.::|::.:|
Mouse   290 FLDILLFARMENEDSMSDKDLRAEVDTFMIEGHDTTASGVSWIFYALATHPEHQQRCREEVQSLL 354

  Fly   346 GEDRKSPVTLRDLGELKFMENVIKESLRLHPPVPMIGRWFAEDVEI-RGKHIPAGTNFTMGIFVL 409
            |:.  |.:|...|.::.:....|||:|||:||||.|||..:..|.. .|..:|.|...|:.|:.|
Mouse   355 GDG--SSITWDHLDQIPYTTMCIKEALRLYPPVPSIGRELSTSVTFPDGCSLPKGVQVTLSIYGL 417

  Fly   410 LRDPEYFESPDEFRPERFDADVPQIHPYAYIPFSAGPRNCIGQKFAMLEMKSTVSKLLRHFELLP 474
            ..:|:.:.:|:.|.|.||..|.|: |.::::|||.|.|||||::|||.|:|..|:..|..|||||
Mouse   418 HHNPKVWPNPEVFDPSRFAPDSPR-HSHSFLPFSGGARNCIGKQFAMSELKVIVALTLLRFELLP 481

  Fly   475 LGPE--PRHSMNIVLRSANGVHLGLK 498
             .|.  |......||:|.||::|.||
Mouse   482 -DPTRVPMSLARFVLKSKNGIYLHLK 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d2	NP_001284806.1	p450	32..495	CDD:278495	156/476 (33%)
Cyp4a31	NP_964002.2	p450	52..503	CDD:278495	150/463 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845106
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.650