DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d2 and CYP3A43

DIOPT Version :9

Sequence 1:	NP_001284806.1	Gene:	Cyp4d2 / 31192	FlyBaseID:	FBgn0011576	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_073731.1	Gene:	CYP3A43 / 64816	HGNCID:	17450	Length:	504	Species:	Homo sapiens

Alignment Length:	519	Identity:	150/519 - (28%)
Similarity:	251/519 - (48%)	Gaps:	59/519 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLVAFATLLLWDF------LWRRRGNGILPGPRPLPFLGNLLMY-RGLDPEQIMDFVKKNQRKYG 66
            :|||.:.:||:.:      |:::.|   :|||.||||||.:|.| |||     .:|.::...|||
Human    13 VLVATSLVLLYIYGTHSHKLFKKLG---IPGPTPLPFLGTILFYLRGL-----WNFDRECNEKYG 69

  Fly    67 RLYRVWILHQLAVFSTDPRDIEFVLSSQQHITKNNLYKLLNC-WLGDGLLMSTGRKWHGRRKIIT 130
            .::.::...|..:...||..|:.||..:.:....|...|... :|...|..:...:|...|.:::
Human    70 EMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIRTLLS 134

  Fly   131 PTFHFKILEQFVEIFDQQSAVMVEQLQSRADGMTPINIFPVICLTALDIIAETAMGTKINAQKNP 195
            |.|.....::.|.|..|...::|..|:..|:....||:........:|:|..|..|..:::..||
Human   135 PAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVNLDSLNNP 199

  Fly   196 NLPYVQAVNDVTNILIKRFIHAWQRVDWIFRLTQPT-EAKRQDKAIKVMHDFTENIIRERRETLV 259
            ..|:::   ::..:|...|:..:..:..:|....|. ||.......|.:..|.:|.|...:|:.:
Human   200 QDPFLK---NMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKDVTHFLKNSIERMKESRL 261

  Fly   260 NNSKETTPEEEVNFLGQKRRMALLDVLLQS-----TIDGAPLSDEDIREEVDTFMFEGHDTTTSA 319
            .:.             ||.|:.....::.|     |.....|||.::..:....:|..:|||::.
Human   262 KDK-------------QKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTT 313

  Fly   320 ISFCLYEISRHPEVQQRLQQEIRDVLGEDRKSPVTLRDLGELKFMENVIKESLRLHPPVPMIGRW 384
            :.|.:||::.||:|||:||:||..||  ..|:|||...|.::::::.|:.|:|||.|.|..:.|.
Human   314 LPFIMYELATHPDVQQKLQEEIDAVL--PNKAPVTYDALVQMEYLDMVVNETLRLFPVVSRVTRV 376

  Fly   385 FAEDVEIRGKHIPAGTNFTMGIFVLLRDPEYFESPDEFRPE-RFD-ADVPQIHPYAYIPFSAGPR 447
            ..:|:||.|..||.|....:.|:.|..||:|:..|::|.|| ||. .:...|..|.||||.||||
Human   377 CKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPESRFSKKNKDSIDLYRYIPFGAGPR 441

  Fly   448 NCIGQKFAMLEMKSTVSKLLRHFELLP---------------LGPEPRHSMNIVLRSANGVHLG 496
            ||||.:||:..:|..|.:.|::|...|               |.||....:.:.||  :|:..|
Human   442 NCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLPILQPEKPIVLKVHLR--DGITSG 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d2	NP_001284806.1	p450	32..495	CDD:278495	142/487 (29%)
CYP3A43	NP_073731.1	p450	39..494	CDD:278495	139/477 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810