Protein Alignment Cyp4d2 and CYP3A43

DIOPT Version :10

• Sequence 1: NP_525043.1
• Gene: Cyp4d2 / 31192
• FlyBaseID: FBgn0011576
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_073731.1
• Gene: CYP3A43 / 64816
• HGNCID: 17450
• Length: 504
• Species: Homo sapiens
• Alignment Length: 519
• Identity: 150/519 - (28%)
• Similarity: 251/519 - (48%)
• Gaps: 59/519 - (11%)

  Fly     9 LLVAFATLLLWDF------LWRRRGNGILPGPRPLPFLGNLLMY-RGLDPEQIMDFVKKNQRKYG 66
            :|||.:.:||:.:      |:::.|   :|||.||||||.:|.| |||     .:|.::...|||
Human    13 VLVATSLVLLYIYGTHSHKLFKKLG---IPGPTPLPFLGTILFYLRGL-----WNFDRECNEKYG 69

  Fly    67 RLYRVWILHQLAVFSTDPRDIEFVLSSQQHITKNNLYKLLNC-WLGDGLLMSTGRKWHGRRKIIT 130
            .::.::...|..:...||..|:.||..:.:....|...|... :|...|..:...:|...|.:::
Human    70 EMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIRTLLS 134

  Fly   131 PTFHFKILEQFVEIFDQQSAVMVEQLQSRADGMTPINIFPVICLTALDIIAETAMGTKINAQKNP 195
            |.|.....::.|.|..|...::|..|:..|:....||:........:|:|..|..|..:::..||
Human   135 PAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVNLDSLNNP 199

  Fly   196 NLPYVQAVNDVTNILIKRFIHAWQRVDWIFRLTQPT-EAKRQDKAIKVMHDFTENIIRERRETLV 259
            ..|:::   ::..:|...|:..:..:..:|....|. ||.......|.:..|.:|.|...:|:.:
Human   200 QDPFLK---NMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKDVTHFLKNSIERMKESRL 261

  Fly   260 NNSKETTPEEEVNFLGQKRRMALLDVLLQS-----TIDGAPLSDEDIREEVDTFMFEGHDTTTSA 319
            .:.             ||.|:.....::.|     |.....|||.::..:....:|..:|||::.
Human   262 KDK-------------QKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTT 313

  Fly   320 ISFCLYEISRHPEVQQRLQQEIRDVLGEDRKSPVTLRDLGELKFMENVIKESLRLHPPVPMIGRW 384
            :.|.:||::.||:|||:||:||..||  ..|:|||...|.::::::.|:.|:|||.|.|..:.|.
Human   314 LPFIMYELATHPDVQQKLQEEIDAVL--PNKAPVTYDALVQMEYLDMVVNETLRLFPVVSRVTRV 376

  Fly   385 FAEDVEIRGKHIPAGTNFTMGIFVLLRDPEYFESPDEFRPE-RFD-ADVPQIHPYAYIPFSAGPR 447
            ..:|:||.|..||.|....:.|:.|..||:|:..|::|.|| ||. .:...|..|.||||.||||
Human   377 CKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPESRFSKKNKDSIDLYRYIPFGAGPR 441

  Fly   448 NCIGQKFAMLEMKSTVSKLLRHFELLP---------------LGPEPRHSMNIVLRSANGVHLG 496
            ||||.:||:..:|..|.:.|::|...|               |.||....:.:.||  :|:..|
Human   442 NCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLPILQPEKPIVLKVHLR--DGITSG 503

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d2	NP_525043.1	CYP4	66..495	CDD:410721	125/452 (28%)
CYP3A43	NP_073731.1	cytochrome_P450	67..493	CDD:477761	124/443 (28%)