DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d2 and Cyp4f14

DIOPT Version :9

Sequence 1:	NP_001284806.1	Gene:	Cyp4d2 / 31192	FlyBaseID:	FBgn0011576	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001191262.1	Gene:	Cyp4f14 / 64385	MGIID:	1927669	Length:	524	Species:	Mus musculus

Alignment Length:	518	Identity:	183/518 - (35%)
Similarity:	280/518 - (54%)	Gaps:	43/518 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 VAF--ATLLLWDFLW---------------RRRGNGILPGPRPLPFLGNLLMYRGLDP-EQIMDF 57
            |||  .||||....|               .|..:|....|:....:|::.|   :.| ||.:..
Mouse    15 VAFPWKTLLLLGASWILARILIQIYAAYRNYRHLHGFPQPPKRNWLMGHVGM---VTPTEQGLKE 76

  Fly    58 VKKNQRKYGRLYRVWILHQLAVFSTDPRDI-EFVLSSQQHITKNNL--YKLLNCWLGDGLLMSTG 119
            :.:....|.:.:.:||...:.|.:....|| ..:|::...:...::  |.:|..|||||||:|.|
Mouse    77 LTRLVGTYPQGFLMWIGPMVPVITLCHSDIVRSILNASAAVALKDVIFYSILKPWLGDGLLVSAG 141

  Fly   120 RKWHGRRKIITPTFHFKILEQFVEIFDQQSAVMVEQLQSR-ADGMTPINIFPVICLTALDIIAET 183
            .||...|:::||.|||.||:.:|:||:..:.:|..:.|.. :||...:::|..:.|..||.:.:.
Mouse   142 DKWSRHRRMLTPAFHFNILKPYVKIFNDSTNIMHAKWQRLISDGSARLDMFEHVSLMTLDSLQKC 206

  Fly   184 AMGTKINAQKNPNLPYVQAVNDVTNILIKRFIHAWQRVDWIFRLTQPTEAKRQDKAIKVMHDFTE 248
            ......|.|:..: .|:.|:.:::.::.||.......:|.::.||  .:..|..||..|:|:||:
Mouse   207 VFSFDSNCQEKSS-EYIAAILELSALVAKRHQQPLMFMDLLYNLT--PDGMRFRKACNVVHEFTD 268

  Fly   249 NIIRERRETLVNNSKETTPEEEV-NFLGQKRRMALLD----VLLQSTIDGAPLSDEDIREEVDTF 308
            .:||||..||        |::.: :||..|.:...||    :||....||..|||||||.|.|||
Mouse   269 AVIRERHRTL--------PDQGLDDFLKSKAKSKTLDFIDVLLLSKDEDGKELSDEDIRAEADTF 325

  Fly   309 MFEGHDTTTSAISFCLYEISRHPEVQQRLQQEIRDVLGEDRKSPVTLRDLGELKFMENVIKESLR 373
            ||||||||.|.:|:.||.::||||.|:|.:||::::|.......:...||.:|.|:...||||||
Mouse   326 MFEGHDTTASGLSWILYNLARHPEYQERCRQEVQELLRGREPEEIEWDDLAQLPFLTMCIKESLR 390

  Fly   374 LHPPVPMIGRWFAEDVEI-RGKHIPAGTNFTMGIFVLLRDPEYFESPDEFRPERFDAD-VPQIHP 436
            |||||.:|.|...:|:.: .|:.||.|....:.||.:..:|..:..|:.:.|.|||.: :....|
Mouse   391 LHPPVTVISRCCTQDILLPDGRTIPKGIICLISIFGIHHNPSVWPDPEVYDPFRFDPENIKDSSP 455

  Fly   437 YAYIPFSAGPRNCIGQKFAMLEMKSTVSKLLRHFELLPLGPEPRHSMNIVLRSANGVHLGLKP 499
            .|:|||||||||||||.|||.|||..::..|..|.|||...|||....::||:..|:.|.::|
Mouse   456 LAFIPFSAGPRNCIGQTFAMSEMKVALALTLLRFRLLPDDKEPRRQPELILRAEGGLWLRVEP 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d2	NP_001284806.1	p450	32..495	CDD:278495	171/474 (36%)
Cyp4f14	NP_001191262.1	p450	52..511	CDD:365848	170/472 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845200
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3295
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.600