DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4d2 and CYP4F11

DIOPT Version :9

Sequence 1:	NP_001284806.1	Gene:	Cyp4d2 / 31192	FlyBaseID:	FBgn0011576	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001122404.1	Gene:	CYP4F11 / 57834	HGNCID:	13265	Length:	524	Species:	Homo sapiens

Alignment Length:	517	Identity:	183/517 - (35%)
Similarity:	290/517 - (56%)	Gaps:	43/517 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VLLLVA----FATLLLWDFLWRRRGNGILPGPRPLP----FLGNLLMYRGL--DPEQIMDFVKKN 61
            :||||.    .|.:|.|.:.:......:...|:| |    |.|    ::||  ..|:.|..:.:.
Human    21 LLLLVGGSWLLARVLAWTYTFYDNCRRLQCFPQP-PKQNWFWG----HQGLVTPTEEGMKTLTQL 80

  Fly    62 QRKYGRLYRVWI--LHQLAVFSTDPRDIEFVLSSQQHITKNNL--YKLLNCWLGDGLLMSTGRKW 122
            ...|.:.:::|:  ...|.:. ..|..|..:.|:...:...::  |..|..|||||||:|.|.||
Human    81 VTTYPQGFKLWLGPTFPLLIL-CHPDIIRPITSASAAVAPKDMIFYGFLKPWLGDGLLLSGGDKW 144

  Fly   123 HGRRKIITPTFHFKILEQFVEIFDQQSAVMVEQLQSRA-DGMTPINIFPVICLTALDIIAETAMG 186
            ...|:::||.|||.||:.:::||::...:|.::.|..| :|...:::|..|.|..||.:.:....
Human   145 SRHRRMLTPAFHFNILKPYMKIFNKSVNIMHDKWQRLASEGSARLDMFEHISLMTLDSLQKCVFS 209

  Fly   187 TKINAQKNPNLPYVQAVNDVTNILIKRFIHAWQRVDWIFRLTQPTEAKRQDKAIKVMHDFTENII 251
            .:.|.|:.|: .|:.|:.:::..:.||........|:::.||  .:.:|..:|..::||||:.:|
Human   210 FESNCQEKPS-EYIAAILELSAFVEKRNQQILLHTDFLYYLT--PDGQRFRRACHLVHDFTDAVI 271

  Fly   252 RERRETLVNNSKETTPEEEV-NFLGQKRRMALLD----VLLQSTIDGAPLSDEDIREEVDTFMFE 311
            :|||.||        |.:.: :||..|.:...||    :||....||..|||||||.|.||||||
Human   272 QERRCTL--------PTQGIDDFLKNKAKSKTLDFIDVLLLSKDEDGKELSDEDIRAEADTFMFE 328

  Fly   312 GHDTTTSAISFCLYEISRHPEVQQRLQQEIRDVLGEDRKSPVTLR--DLGELKFMENVIKESLRL 374
            |||||.|.:|:.||.:::|||.|::.:||::::| :||: |:.:.  ||.:|.|:...|||||||
Human   329 GHDTTASGLSWVLYHLAKHPEYQEQCRQEVQELL-KDRE-PIEIEWDDLAQLPFLTMCIKESLRL 391

  Fly   375 HPPVPMIGRWFAEDVEI-RGKHIPAGTNFTMGIFVLLRDPEYFESPDEFRPERFDAD-VPQIHPY 437
            |||||:|.|...:|..: .|:.||.|....:.|..:..:|..:..|:.:.|.|||.: :.:..|.
Human   392 HPPVPVISRCCTQDFVLPDGRVIPKGIVCLINIIGIHYNPTVWPDPEVYDPFRFDQENIKERSPL 456

  Fly   438 AYIPFSAGPRNCIGQKFAMLEMKSTVSKLLRHFELLPLGPEPRHSMNIVLRSANGVHLGLKP 499
            |:|||||||||||||.|||.|||..::..|.||.:||...|||....::||:..|:.|.::|
Human   457 AFIPFSAGPRNCIGQAFAMAEMKVVLALTLLHFRILPTHTEPRRKPELILRAEGGLWLRVEP 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d2	NP_001284806.1	p450	32..495	CDD:278495	174/482 (36%)
CYP4F11	NP_001122404.1	p450	52..506	CDD:365848	171/472 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154758
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.650