Protein Alignment Cyp4d2 and CYP26B1

DIOPT Version :9

• Sequence 1: NP_001284806.1
• Gene: Cyp4d2 / 31192
• FlyBaseID: FBgn0011576
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_063938.1
• Gene: CYP26B1 / 56603
• HGNCID: 20581
• Length: 512
• Species: Homo sapiens
• Alignment Length: 528
• Identity: 120/528 - (22%)
• Similarity: 218/528 - (41%)
• Gaps: 98/528 - (18%)

  Fly     4 VVGVLLLVAFATLLLWDFLW--RRRGNGILPGPR---PLPFLGN----LLMYRGLDPEQIMDFVK 59
            :|.|.||:| .:..||...|  .|..:..||.|:   ..|.:|.    ||...|        |..
Human    19 LVSVTLLLA-VSQQLWQLRWAATRDKSCKLPIPKGSMGFPLIGETGHWLLQGSG--------FQS 74

  Fly    60 KNQRKYGRLYRVWILHQLAVFSTDPRDIEFVLSSQQHITKNNLYKLLNCWLGDGLLM-STGRKWH 123
            ..:.|||.:::..:|.:..:..|...::..:|..:.|:......:.....||...:. |.|....
Human    75 SRREKYGNVFKTHLLGRPLIRVTGAENVRKILMGEHHLVSTEWPRSTRMLLGPNTVSNSIGDIHR 139

  Fly   124 GRRKIITPTFHFKILEQFVEIFDQQSAVMVEQLQSRADGMTPINIFPVICLTALDIIAETAMGTK 188
            .:||:.:..|..:.||.::   .:...|:.:.|::.:.....||::.
Human   140 NKRKVFSKIFSHEALESYL---PKIQLVIQDTLRAWSSHPEAINVYQ------------------ 183

  Fly   189 INAQKNPNLPYVQAVNDVTNILIK-----RFIHAWQR-VDWIFRLTQPTEA-----KRQDKAIKV 242
             .|||   |.:..|:..:....|.     .....:|: ||.:|.|  |.:.     :|..:|.::
Human   184 -EAQK---LTFRMAIRVLLGFSIPEEDLGHLFEVYQQFVDNVFSL--PVDLPFSGYRRGIQARQI 242

  Fly   243 MHDFTENIIRERRETLVNNSKETTPEEEVNFLGQKRRMALLDVLLQSTID-GAPLSDEDIREEVD 306
            :....|..|||:.:....                |..:..||:|::|:.: |..::.:::::...
Human   243 LQKGLEKAIREKLQCTQG----------------KDYLDALDLLIESSKEHGKEMTMQELKDGTL 291

  Fly   307 TFMFEGHDTTTSAISFCLYEISRHPEVQQRLQQEIR--DVL---GEDRKSPVTLRDLGELKFMEN 366
            ..:|..:.||.||.:..:.::.:||.|.::|:.|:|  .:|   |...:..:.|..|..|::::.
Human   292 ELIFAAYATTASASTSLIMQLLKHPTVLEKLRDELRAHGILHSGGCPCEGTLRLDTLSGLRYLDC 356

  Fly   367 VIKESLRLHPPVPMIGRWFAEDVEIRGKHIPAG---------TNFTMGIFVLLRDPEYFESPDEF 422
            ||||.:||..|:....|...:..|:.|..||.|         |:.|..:|   :|...|: ||.|
Human   357 VIKEVMRLFTPISGGYRTVLQTFELDGFQIPKGWSVMYSIRDTHDTAPVF---KDVNVFD-PDRF 417

  Fly   423 RPERFDADVPQIHPYAYIPFSAGPRNCIGQKFAMLEMKSTVSKL--LRHFELLPLGPEPRHSMNI 485
            ...|.:....:.|   |:||..|.|.|:|:..|.|.:|....:|  ...|| |.....||.::..
Human   418 SQARSEDKDGRFH---YLPFGGGVRTCLGKHLAKLFLKVLAVELASTSRFE-LATRTFPRITLVP 478

  Fly   486 VLRSANGV 493
            ||...:|:
Human   479 VLHPVDGL 486

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d2	NP_001284806.1	p450	32..495	CDD:278495	110/498 (22%)
CYP26B1	NP_063938.1	p450	23..490	CDD:325183	118/524 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910