Protein Alignment Cyp4d2 and Cyp3a25

DIOPT Version :10

• Sequence 1: NP_525043.1
• Gene: Cyp4d2 / 31192
• FlyBaseID: FBgn0011576
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_062766.2
• Gene: Cyp3a25 / 56388
• MGIID: 1930638
• Length: 503
• Species: Mus musculus
• Alignment Length: 540
• Identity: 149/540 - (27%)
• Similarity: 255/540 - (47%)
• Gaps: 102/540 - (18%)

  Fly    11 VAFATLLLWDFLWRRRGNGI-----LPGPRPLPFLGNLLMYRGLDPEQIMDFVKKNQRKYGRLYR 70
            |...|.|:..:::....:|:     :|||:|||.||.:..|.    :.:..|.:...:|||   :
Mouse    13 VLLVTSLVLFYIYGTYSHGLFKKLGIPGPKPLPLLGTIFNYY----DGMWKFDEDCYKKYG---K 70

  Fly    71 VWILHQ-----LAVFSTDPRDIEFVLSSQQH--ITKNNLYKLLNCWLGDGLLMSTGRKWHGRRKI 128
            :|..::     ||:.  ||..|:.||..:.:  .|....:..:. ::...:.:|...:|...|.:
Mouse    71 IWGFYEGPQPILAIM--DPEIIKIVLVKECYSVFTNRRFFGPVG-FMKKAITISEDEEWKRLRTL 132

  Fly   129 ITPTFHFKILEQFVEIFDQQSAVMVEQLQSRADGMTPINIFPVICLTALDIIAETAMGTKINAQK 193
            ::|||....|::...|..|...::|..|:...:...||::..:....::|:|..|:.|..:::..
Mouse   133 LSPTFTSGKLKEMFPIMRQYGDILVRNLRREEEKGEPISMKDIFGAYSMDVITGTSFGVNVDSLN 197

  Fly   194 NPNLPYVQAVNDVTN-----------ILIKRFIHAWQRVDW-IFRLTQPTEAKRQDKAIKVMHDF 246
            ||..|:||....:..           ||.......::.::: ||    |.::         |:.|
Mouse   198 NPQDPFVQKAKKILKFKIFDPFLLSIILFPFLTPIYEMLNFSIF----PRDS---------MNFF 249

  Fly   247 TENIIRERRETLVNNSKETTPEEEVNFL----------GQKRRMALLDVLLQSTIDGAPLSDEDI 301
            .:.:.|.::|.|.:|.|     ..|:||          ||:.:.|              |||.::
Mouse   250 KKFVKRMKKERLASNQK-----NRVDFLQLMMNTQNSKGQESQKA--------------LSDLEM 295

  Fly   302 REEVDTFMFEGHDTTTSAISFCLYEISRHPEVQQRLQQEIRDVLGEDRKSPVTLRDLGELKFMEN 366
            ..:...|:|.|:|.|:::||..:||::.||:||::||.||...|  ..|:|||...|.::::::.
Mouse   296 AAQAVIFIFGGYDATSTSISLIMYELATHPDVQKKLQDEIDRTL--PNKAPVTYDALMDMEYLDM 358

  Fly   367 VIKESLRLHPPVPMIGRWFAEDVEIRGKHIPAGTNFTMGIFVLLRDPEYFESPDEFRPERFDAD- 430
            |:.|||||:|....:.|...:||||.|..||.||...:.|:.|.|:|||:..|.||.||||..:
Mouse   359 VVNESLRLYPIAIRLERVSKKDVEINGVFIPKGTVVMIPIYPLHRNPEYWPEPQEFCPERFSKEN 423

  Fly   431 VPQIHPYAYIPFSAGPRNCIGQKFAMLEMKSTVSKLLRHFELLP---------------LGPEPR 480
            ...|.||.|:||..|||||||.:||::.:|..|..:|::|.:.|               ..||..
Mouse   424 KGNIDPYIYMPFGNGPRNCIGMRFALISIKLAVIGVLQNFTVQPCEETQIPLKISREPIFQPEKP 488

  Fly   481 HSMNIVLRSANGVHLGLKPR 500
            ..:.:|.|.        |||
Mouse   489 IILKVVSRD--------KPR 500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d2	NP_525043.1	CYP4	66..495	CDD:410721	130/473 (27%)
Cyp3a25	NP_062766.2	CYP3A	67..492	CDD:410743	130/464 (28%)