DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d2 and cyp4v8

DIOPT Version :9

Sequence 1:	NP_001284806.1	Gene:	Cyp4d2 / 31192	FlyBaseID:	FBgn0011576	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001071070.1	Gene:	cyp4v8 / 558851	ZFINID:	ZDB-GENE-061103-601	Length:	513	Species:	Danio rerio

Alignment Length:	531	Identity:	211/531 - (39%)
Similarity:	318/531 - (59%)	Gaps:	54/531 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLGVVGV---------LLLVAFATL---LLWDFLWRRRGNGILPG-PRPLPFLGNLLMYR--GLD 50
            |:..|||         :.::.||.:   ||..:|.:.:....:|| ....||:||.|.::  |..
Zfish     1 MVAFVGVYTYGFVAASVCVICFAYITYQLLKSYLHKWKELKPIPGIGNTFPFIGNALQFKSNGDF 65

  Fly    51 PEQIMDFVKKNQRKYGRLYRVWI--LHQLAVFSTDPRDIEFVLSSQQHITKNNLYKLLNCWLGDG 113
            ..|::.:..:.|.  ..|.::||  :..|.:|..:  .:|.||::..||.|...|:.|:.|||.|
Zfish    66 FLQLVGYTTEFQN--SPLLKIWIGPIPFLILFHAE--TVETVLNNPVHIDKAYAYQFLHPWLGTG 126

  Fly   114 LLMSTGRKWHGRRKIITPTFHFKILEQFVEIFDQQSAVMVEQLQSRADGMTPINIFPVICLTALD 178
            ||.|||.||..|||::||||||.||.:|:|:.::|:.|::|:|:.:| |..|.|.|..|.|.|||
Zfish   127 LLTSTGDKWRRRRKMLTPTFHFSILTEFLEVMNEQAEVLIEKLEKQA-GKGPFNCFSHITLCALD 190

  Fly   179 IIAETAMGTKINAQKNPNLPYVQAVNDVTNILIKRFIHAWQRVDWIFRLTQPTEAKRQDKAIKVM 243
            ||.|||||.:|.||.|.:..||:.|..:::|:.:|....|...|:::...  .|.:..::::|::
Zfish   191 IICETAMGKRIYAQSNYDSEYVRTVYRMSDIITRRQRMPWYWPDFVYNYV--GEGREHNRSLKIL 253

  Fly   244 HDFTENIIRERRETLVNNSKETTPEEEVNFLGQKRRMALLDVLLQS-TIDGAPLSDEDIREEVDT 307
            |.|||::|.||.|.|.....::..::     |.::|.|.||:||:: ..||..|:.:||:|||||
Zfish   254 HSFTESVINERAEYLSYVESDSESDQ-----GMRKRRAFLDMLLKTKDEDGKMLTHKDIQEEVDT 313

  Fly   308 FMFEGHDTTTSAISFCLYEISRHPEVQQRLQQEIRDVLGEDRKSPVTLRDLGELKFMENVIKESL 372
            |||||||||.:|:::.::.:..|||||::.|||:.:|.||..: ||...||.:|:::|.||||||
Zfish   314 FMFEGHDTTAAAMNWAIHLLGSHPEVQRKAQQELFEVFGESER-PVNTEDLKKLRYLECVIKESL 377

  Fly   373 RLHPPVPMIGRWFAEDVEIRGKHIPAGTNFTMGIFVLLRDPEYFESPDEFRPERFDADVPQ---- 433
            ||.|.||...|...:|.:|.|..:|.|||..:..:.|.|||.:|..|:|||||||   :|:
Zfish   378 RLFPSVPFFARTICDDTQINGFKVPKGTNIVVITYALHRDPRFFPDPEEFRPERF---LPENCVG 439

  Fly   434 IHPYAYIPFSAGPRNCIGQKFAMLEMKSTVSKLLRHF---------ELLPLGPEPRHSMNIVLRS 489
            .|||||||||||.||||||:||::|.|..::.:||:|         ||.|||       .:|||.
Zfish   440 RHPYAYIPFSAGLRNCIGQRFAIMEEKVILAYILRYFNIVACQKREELRPLG-------ELVLRP 497

  Fly   490 ANGVHLGLKPR 500
            ..|:.:.|:.|
Zfish   498 EQGIWITLERR 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d2	NP_001284806.1	p450	32..495	CDD:278495	200/481 (42%)
cyp4v8	NP_001071070.1	p450	44..501	CDD:278495	199/479 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589827
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	LDO	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.750