DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4d2 and cyp3c4

DIOPT Version :9

Sequence 1:	NP_001284806.1	Gene:	Cyp4d2 / 31192	FlyBaseID:	FBgn0011576	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001071016.1	Gene:	cyp3c4 / 558541	ZFINID:	ZDB-GENE-060929-96	Length:	507	Species:	Danio rerio

Alignment Length:	537	Identity:	150/537 - (27%)
Similarity:	251/537 - (46%)	Gaps:	91/537 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLVAFATLLLWDFLWRRR-----GNGILPGPRPLPFLGNLLMY-RGLDPEQIMDFVKKNQRKYGR 67
            |:|...|||....:|..|     |   :|||||.||:|.||.| :||     .:|..:..:|||:
Zfish    13 LVVLVITLLFIYGVWPHRFFIKLG---IPGPRPWPFVGTLLSYAKGL-----CNFDMECAKKYGK 69

  Fly    68 LYRVWILHQLAVFSTDPRDIEFVLSSQQHITKNNLYKLLNCWLG---DGLLMSTGRKWHGRRKII 129
            ::.::......:...|...|:.||..:.:....|..|......|   ||::|....:|...|..:
Zfish    70 VWGIYDGRLPILMVADLEVIKVVLVKECYSNFINRRKRTTGLAGPFSDGIIMVKDERWKRMRSTL 134

  Fly   130 TPTFHFKILEQFVEIFDQQSAVMVEQLQSRADGMTPINIFPVICLTALDIIAETAMGTKINAQKN 194
            :|.|....|::...|....:...::.:|.: |...|:.|..|:...:||:|..::....|::..|
Zfish   135 SPYFTSGRLKEIFPIAMTHADRFIKNMQKK-DPEQPVKIKEVVAPYSLDVITSSSFSVDIDSINN 198

  Fly   195 PNLPYVQAVNDVTNILIKRFIHAWQRVDWIFRLTQP------------TEAKRQDKAI--KVMHD 245
            |..|:|        |.:|:||.        |.:..|            ...|:....:  |...|
Zfish   199 PEDPFV--------INVKKFIQ--------FNMFNPLLLLILLFPSLAIPLKKMGVTLFSKSAMD 247

  Fly   246 FTENIIRERRETLVNNSKETTPEEEVNFLGQKRRMALLDVLLQSTIDGAPLSDEDIREE-----V 305
            |..:::::.::   :::||:  |..|:|         |.::||:.|....:.|.|..|:     .
Zfish   248 FFYSVLKKIKD---DHNKES--EGRVDF---------LKLMLQNQIPDDQIQDSDTSEQPAKGLT 298

  Fly   306 D--------TFMFEGHDTTTSAISFCLYEISRHPEVQQRLQQEIRDVLGEDRKSPVTLRDLGELK 362
            |        .|:..|::||::.::|.||.::.:|:..::|.:||......|  :|:|...|..:.
Zfish   299 DHEILSQSLVFILGGYETTSTTLTFLLYNLATNPDCLEKLVEEIDKNFPLD--TPITYDALMRMD 361

  Fly   363 FMENVIKESLRLHPPVPMIGRWFAEDVEIRGKHIPAGTNFTMGIFVLLRDPEYFESPDEFRPERF 427
            ::|..|.||:||.|..|.:.|...:.|.|.|..||.||...:..:||..||:.:|||.|||||||
Zfish   362 YLEMAINESMRLLPTAPRLERSAKKTVVINGLTIPEGTLVGIPTYVLSHDPDIWESPGEFRPERF 426

  Fly   428 DAD-VPQIHPYAYIPFSAGPRNCIGQKFAMLEMKSTVSKLLRHFEL-------LPLGPEPRHSMN 484
            ..: ..:...||:|||..|||||||.::|::.||..|.|||::|.:       :||      .||
Zfish   427 SPENKSEFLQYAFIPFGLGPRNCIGMRYAVMIMKLFVVKLLQNFSVETCKETQIPL------EMN 485

  Fly   485 IVLRSANGVHLGLKPRA 501
            :..:....:.|.|.||:
Zfish   486 VTFQPKVPITLKLIPRS 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d2	NP_001284806.1	p450	32..495	CDD:278495	138/501 (28%)
cyp3c4	NP_001071016.1	p450	38..485	CDD:278495	136/490 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900