DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4d2 and cyp26c1

DIOPT Version :9

Sequence 1:	NP_001284806.1	Gene:	Cyp4d2 / 31192	FlyBaseID:	FBgn0011576	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001025122.2	Gene:	cyp26c1 / 554036	ZFINID:	ZDB-GENE-050714-2	Length:	554	Species:	Danio rerio

Alignment Length:	573	Identity:	116/573 - (20%)
Similarity:	220/573 - (38%)	Gaps:	126/573 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VVGVLLLVAFATL----------LLWDFLW--RRRGNGILP---GPRPLPFLGNLL--MYRGLDP 51
            :|..||.||.|.|          |||:|.|  .|.....||   |....|.:|...  :::|
Zfish     8 LVSALLSVADAVLPTVLLLAVSRLLWEFRWSITRDRTCKLPLPQGSMGWPLVGETFHWLFQG--- 69

  Fly    52 EQIMDFVKKNQRKYGRLYRVWILHQLAVFSTDPRDIEFVLSSQQHITKNNLYKLLNCWLGDGLLM 116
               ..|....:.|:|::::..:|.:..:..|...:|..:|..:..:......:.....||...|:
Zfish    70 ---SSFHISRREKHGKVFKTHLLGKPLIRVTGAENIRKILLGEHTVVCTQWPQSTRIILGPNTLV 131

  Fly   117 STGRKWHGR-RKIITPTFHFKILEQFVEIFDQQSAVMVEQLQSRADGMTPINIFPVICLTALDII 180
            ::....|.| ||::...|....||.::   .:...|:..::.........:.::.........|.
Zfish   132 NSVGDLHKRKRKVLAKVFSRGALEAYL---TRLQDVVKSEIAKWCTETGSVEVYTAAKSLTFRIA 193

  Fly   181 AETAMGTKINAQKNPNL--PYVQAVNDVTNILIKRFIHAWQRVDWIFRLTQPTEAKRQDKAIKVM 243
            ....:|..:..|:...|  .:.|.:|::.::.|.               |..:..::..:|.:::
Zfish   194 VRVLLGLHLEEQQITYLSKTFEQLMNNLFSLPID---------------TPVSGLRKGIRAREIL 243

  Fly   244 HDFTENIIRERRETLVNNSKETTPEEEVNFLGQKRRMA-----LLDVLLQSTIDG-APLSDEDIR 302
            |...|.||.|:                     .|::.|     ..|.:|.|..:. ..|:.::::
Zfish   244 HSAMEKIIEEK---------------------LKKQQASDYCDAFDYMLSSARENDYELTMQELK 287

  Fly   303 EEVDTFMFEGHDTTTSAISFCLYEISRHPEVQQRLQQEIR------------------DVLGE-- 347
            |.....:|..|.||.||.:..:.::.|||:|.:|.:.|:.                  :.:.|
Zfish   288 ETAVELIFAAHSTTASASTSLIMQLLRHPDVSERARAELESEGLITDGHGHCRSRCNGNAISEEG 352

  Fly   348 --------DRKSPV------------------------TLRDLGELKFMENVIKESLRLHPPVPM 380
                    ||:|.:                        :|..|.:|.:::.|:||.||..|||..
Zfish   353 EAAEKSTSDRRSAINKATYFEAGDKEEGRRSRTHVPYLSLEKLSQLSYLDCVVKEVLRFLPPVSG 417

  Fly   381 IGRWFAEDVEIRGKHIPAGTNFTMGIFVLLRDPEYFESPDEFRPERF--DADVPQIHPYAYIPFS 443
            ..|...:..|:.|..||.|.:....|.......|.:::|:.|.|:||  ..:..:...::|:||.
Zfish   418 GYRTVLQTFELNGYQIPKGWSVMYSIRDTHETAEAYQNPELFDPDRFCVGREESKSERFSYVPFG 482

  Fly   444 AGPRNCIGQKFAMLEMKSTVSKLLRHFE-LLPLGPEPRHSMNIVLRSANGVHL 495
            .|.|.|||::.|::.:|:...:||...: .|.....||.....::...||:|:
Zfish   483 GGVRRCIGRELALIVLKTLAVELLATADCTLATQTYPRMQTVPIVHPVNGLHV 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d2	NP_001284806.1	p450	32..495	CDD:278495	101/531 (19%)
cyp26c1	NP_001025122.2	p450	23..533	CDD:299894	107/554 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910