DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d2 and cyp3a65

DIOPT Version :9

Sequence 1:	NP_001284806.1	Gene:	Cyp4d2 / 31192	FlyBaseID:	FBgn0011576	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001032515.1	Gene:	cyp3a65 / 553969	ZFINID:	ZDB-GENE-050604-1	Length:	517	Species:	Danio rerio

Alignment Length:	543	Identity:	140/543 - (25%)
Similarity:	242/543 - (44%)	Gaps:	102/543 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LVAFATLLL-----WDF-LWRRRGNGILPGPRPLPFLGNLLMYRGLDPEQIMD---FVKKNQRKY 65
            |:||...||     |.. .:::.|   :|||:.:||.|.:|.|:  |...:.|   |     .||
Zfish    10 LLAFLAALLVIYGSWPHRYFKKLG---IPGPKAIPFFGTMLRYK--DGFHVFDMDCF-----EKY 64

  Fly    66 GRLYRVWILHQLAVFSTDPRDIEFVLSSQQH--ITKNNLYKLLNCWLGDGLLMSTGRKWHGRRKI 128
            ||::.::...|..:...|...|:.||..:.:  .|....:: ||..|.|.:.::....|...|.:
Zfish    65 GRIWGIYDGRQPVLCIMDQTIIKTVLIKECYSLFTNRRNFR-LNGALYDAVSIAEDDDWRRIRSV 128

  Fly   129 ITPTFHFKILEQFVEIFDQQSAVMVEQLQSRADGMTPINIFPVICLTALDIIAETAMGTKINAQK 193
            ::|:|....|::...|..:.|.::|:.:...|......:|.......::|::..||....|::..
Zfish   129 LSPSFTSGRLKEMFGIMKKHSHILVDSMGKTAKRGESADIKEFFGAYSMDVVTSTAFSVDIDSLN 193

  Fly   194 NPNLPYVQAVN-----DVTN---ILIKRF-------------IHAWQRVDWIFRLTQPTEAKRQD 237
            ||..|:|..:.     |:.|   :||..|             :......|:.:...|..::.|..
Zfish   194 NPKDPFVTNIKKMLKFDLLNPLFLLIAFFPFMAPVLEKMDFALFPTSVTDFFYAALQKIKSDRDT 258

  Fly   238 KAIKVMHDFTENIIRERRETLVNNSKETTPEEEVNFLGQKRRMALLDVLLQSTI------DG--- 293
            |.:                     :|:.|          |:|:..|.:::.|..      ||
Zfish   259 KTV---------------------AKDNT----------KKRVDFLQLMVDSQTGVKHKSDGEHT 292

  Fly   294 -APLSDEDIREEVDTFMFEGHDTTTSAISFCLYEISRHPEVQQRLQQEIRDVLGEDRKSPVTLRD 357
             ..|||.:|..:...|:|.|::|::|.:||..|.::.:||..::||:||.:..  ..::||....
Zfish   293 EKGLSDHEILSQSMIFIFAGYETSSSTLSFLFYNLATNPETMKKLQEEIDETF--PNQAPVDYET 355

  Fly   358 LGELKFMENVIKESLRLHPPVPMIGRWFAEDVEIRGKHIPAGTNFTMGIFVLLRDPEYFESPDEF 422
            |..:.:::..:.|||||.|....:.|...:.|||.|..||......:..:.|.|||:|:..|:.|
Zfish   356 LMSMDYLDAALSESLRLFPVAARLERVCKKTVEINGLLIPKDLVVMVPTYALHRDPDYWSEPESF 420

  Fly   423 RPERF-DADVPQIHPYAYIPFSAGPRNCIGQKFAMLEMKSTVSKLLRHFEL---------LPLGP 477
            :|||| ..:...|.||.|:||..|||||||.:||.:.||..:.::|:.|::         |.||
Zfish   421 KPERFTKGNKESIDPYMYMPFGLGPRNCIGMRFAQVTMKLAIVEILQRFDVSVCDETQVPLELG- 484

  Fly   478 EPRHSMNIVLRSANGVHLGLKPR 500
                 .|.:|...:.:.|.|:||
Zfish   485 -----FNGLLSPKDPIKLKLQPR 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d2	NP_001284806.1	p450	32..495	CDD:278495	129/508 (25%)
cyp3a65	NP_001032515.1	p450	35..499	CDD:278495	130/510 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810