Protein Alignment Cyp4d2 and CYP2W1

DIOPT Version :10

• Sequence 1: NP_525043.1
• Gene: Cyp4d2 / 31192
• FlyBaseID: FBgn0011576
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: XP_011513742.1
• Gene: CYP2W1 / 54905
• HGNCID: 20243
• Length: 564
• Species: Homo sapiens
• Alignment Length: 520
• Identity: 124/520 - (23%)
• Similarity: 205/520 - (39%)
• Gaps: 114/520 - (21%)

  Fly     8 LLLVAFATLL-LWDFL------------WRRRGNGILPGPRPLPFLGNLLMYR-GLDPEQIMDFV 58
            |||:.|..|| ||..|            |.       |||||||.:|||.:.| ......:|:.
Human     3 LLLLLFLGLLGLWGLLCACAQDPSPAARWP-------PGPRPLPLVGNLHLLRLSQQDRSLMEL- 59

  Fly    59 KKNQRKYGRLYRVWILHQLAVFSTDPRDIEFVLSSQ-QHITKN---NLYKLLNCWLGDGLLMSTG 119
               ..:||.::.|.:..|..|..|....::..|:.. |.:...   .:::|:.  .|.|:..|:|
Human    60 ---SERYGPVFTVHLGRQKTVVLTGFEAVKEALAGPGQELADRPPIAIFQLIQ--RGGGIFFSSG 119

  Fly   120 RKWHGRRKIITPTFHF----------KILEQFVEIFDQQSAVMVEQLQSRADGMTPINIF----- 169
            .:|...|:......|.          |||::...:..|..............|..|.||.
Human   120 ARWRAARQFTVRALHSLGVGREPVADKILQELKCLSGQLDGYRGRPFPLALLGWAPSNITFALLF 184

  Fly   170 --------PVICLTALDIIAE--TAMGTKINAQKNPNLPYVQAVNDVTNILIKRFIHAWQRVDWI 224
                    ||. ::.|.:|.|  ..:|:          |.:|..|          ::.|  :..:
Human   185 GRRFDYRDPVF-VSLLGLIDEVMVLLGS----------PGLQLFN----------VYPW--LGAL 226

  Fly   225 FRLTQPTEAKRQDKAIKVMHDFTENIIRERRETLVNNSKETTPEEEVNFLGQKRRMALLDVLLQS 289
            .:|.:|...|     |:.:......::..||       ....|.:.|        .:.:|.|:|
Human   227 LQLHRPVLRK-----IEEVRAILRTLLEARR-------PHVCPGDPV--------CSYVDALIQ- 270

  Fly   290 TIDGAPLSDEDIREEVDT------FMFEGHDTTTSAISFCLYEISRHPEVQQRLQQEIRDVLGED 348
              .|.....|.:..|.:.      .:..|.:||::.:.:....:.|||:||.|:|:|:..|||..
Human   271 --QGQGDDPEGLFAEANAVACTLDMVMAGTETTSATLQWAALLMGRHPDVQGRVQEELDRVLGPG 333

  Fly   349 RKSPVTLRDLGELKFMENVIKESLRLHPPVPMIGRWFAEDVEIRGKHIPAGTNFTMGIFVLLRDP 413
            | :| .|.|...|.:...|:.|..|....:|.:.|..|.|.::.|..:|.||.....:..:|.|.
Human   334 R-TP-RLEDQQALPYTSAVLHEVQRFITLLPHVPRCTAADTQLGGFLLPKGTPVIPLLTSVLLDE 396

  Fly   414 EYFESPDEFRPERF-DADVPQIHPYAYIPFSAGPRNCIGQKFAMLEMKSTVSKLLRHFELLPLGP 477
            ..:::|.:|.|..| ||:...:...|::|||||.|.|:|::.|..|:....:.||   :..|.||
Human   397 TQWQTPGQFNPGHFLDANGHFVKREAFLPFSAGRRVCVGERLARTELFLLFAGLL---QSSPQGP 458

  Fly   478  477
            Human   459  458

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d2	NP_525043.1	CYP4	66..495	CDD:410721	101/448 (23%)
CYP2W1	XP_011513742.1	cytochrome_P450	63..459	CDD:477761	102/449 (23%)