DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d2 and Cyp26c1

DIOPT Version :9

Sequence 1:	NP_001284806.1	Gene:	Cyp4d2 / 31192	FlyBaseID:	FBgn0011576	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001098671.1	Gene:	Cyp26c1 / 546726	MGIID:	2679699	Length:	518	Species:	Mus musculus

Alignment Length:	505	Identity:	115/505 - (22%)
Similarity:	196/505 - (38%)	Gaps:	78/505 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLGVVGVLLLVAFATL----LLWDFLW--RRRGNGILPGPR---PLPFLGNLLMYRGLDPEQIMD 56
            :||..|..||.|...|    .||...|  .|.....||.|:   ..||.|..|.:.    .|...
Mouse    11 VLGAAGTTLLCAGLLLGLAQQLWTLRWTLSRDWASTLPLPKGSMGWPFFGETLHWL----VQGSR 71

  Fly    57 FVKKNQRKYGRLYRVWILHQLAVFSTDPRDIEFVLSSQQHITKNNLYKLLNCWLGD-GLLMSTGR 120
            |....:.:||.:::..:|.:..:..:...::..:|..:..:.::...:..:..||. .||.:.|.
Mouse    72 FHSSRRERYGTVFKTHLLGRPVIRVSGAENVRTILLGEHRLVRSQWPQSAHILLGSHTLLGAVGE 136

  Fly   121 KWHGRRKIITPTFHFKILEQFVEIFDQQSAVMVEQLQSRADGMTPINIFPVICLTALDIIAETAM 185
            ....|||::...|....|||||   .:....:..:::|......|:.::.........:.|...:
Mouse   137 PHRQRRKVLARVFSRSSLEQFV---PRLQGALRREVRSWCAAQRPVAVYQAAKALTFRMAARILL 198

  Fly   186 GTKINAQKNPNLPYVQAVNDVTNILIKRFIHAW-QRVDWIFRLTQPTEAKRQDKAIKVMHDFTEN 249
            |.:::..:...|                 .|.: |.|:.:|.|..........|.|:......|:
Mouse   199 GLQLDEARCTEL-----------------AHTFEQLVENLFSLPLDVPFSGLRKGIRARDQLYEH 246

  Fly   250 IIRERRETLVNNSKETTPEEEVNFLGQKRRMALLDVLLQSTIDGAPLSDEDIREEVDTFMFEGHD 314
            :.....|.|  ..|:|....:          |||.::..:...|...|.::::|.....:|....
Mouse   247 LDEAVAEKL--QEKQTAEPGD----------ALLLIINSARELGHEPSVQELKELAVELLFAAFF 299

  Fly   315 TTTSAISFCLYEISRHPEVQQRLQQEIRDVLGEDRK---------SP--------VTLRDLGELK 362
            ||.||.:..:..:.:||....::|||: ...|..|.         ||        ::|..||.|:
Mouse   300 TTASASTSLILLLLQHPAAITKIQQEL-SAQGLGRACTCTPRASGSPPDCGCEPDLSLAMLGRLR 363

  Fly   363 FMENVIKESLRLHPPVPMIGRWFAEDVEIRGKHIPAGTNFTMGIFVLLRDPE-----YFESPDEF 422
            :::.|:||.|||.|||....|......|:.|..||.|    ..:...:||..     |...|:.|
Mouse   364 YVDCVVKEVLRLLPPVSGGYRTALRTFELDGYQIPKG----WSVMYSIRDTHETAAVYRSPPEGF 424

  Fly   423 RPERFDADVPQIH----PYAYIPFSAGPRNCIGQKFAMLEMKSTVSKLLR 468
            .||||..:.....    .:.||||..|.|:|:||:.|...::....:|:|
Mouse   425 DPERFGVESGDARGSGGRFHYIPFGGGARSCLGQELAQAVLQLLAVELVR 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d2	NP_001284806.1	p450	32..495	CDD:278495	103/468 (22%)
Cyp26c1	NP_001098671.1	p450	40..500	CDD:386267	105/476 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910