DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d2 and Cyp6a22

DIOPT Version :9

Sequence 1:	NP_001284806.1	Gene:	Cyp4d2 / 31192	FlyBaseID:	FBgn0011576	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001286431.1	Gene:	Cyp6a22 / 49847	FlyBaseID:	FBgn0013773	Length:	499	Species:	Drosophila melanogaster

Alignment Length:	570	Identity:	145/570 - (25%)
Similarity:	226/570 - (39%)	Gaps:	156/570 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLGVVGVLLLVAFATLLLWDFL------WRRRGNGILPGPRPL---------------------- 37
            ||.|| .|||:|.| :..| |:      |.|||.|..|...|:
  Fly     1 MLDVV-ALLLIALA-VGFW-FVRTRYSYWTRRGIGSEPARFPVGNMEGFRKNKHFIDIVTPIYEK 62

  Fly    38 ------PFLGNLLMYRGL----DPE-----QIMDFVK-------KNQRK---YGRLYRVWILHQL 77
                  ||.|..:|.|.:    |.|     .|.||..       .|:|.   .|.|:|:
  Fly    63 FKGNGAPFAGFFMMLRPVVLVTDLELAKQILIQDFANFEDRGMYHNERDDPLTGHLFRI------ 121

  Fly    78 AVFSTDPRDIEFVLSSQQHITKNNLYKLLNCWLGDGLLMSTGRKWHGRRKIITPTF-HFKILEQF 141
                                                    .|.||...|:.::||| ..|:...|
  Fly   122 ----------------------------------------DGPKWRPLRQKMSPTFTSAKMKYMF 146

  Fly   142 ---VEIFDQQSAVMVEQLQSRADGMTPINIFPVICLTALDIIAETAMGTKINAQKNPNLPYV--- 200
               .|:.::.:.|..|...:...|:  :.|..::.....|:|...|.|.:.|..:||...:.
  Fly   147 PTVCEVGEELTQVCGELADNAMCGI--LEIGDLMARYTSDVIGRCAFGVECNGLRNPEAEFAIMG 209

  Fly   201 -QAVNDVTNI-LIKRFIHAWQRVDWIFRLTQPTEAKRQDKAIKVMHDFTENIIRERRETLVNNSK 263
             :|.::..:. |:..||.::..|....|:.|    ..||     :.||...|:|
  Fly   210 RRAFSERRHCKLVDGFIESFPEVARFLRMRQ----IHQD-----ITDFYVGIVR----------- 254

  Fly   264 ETTPEEEVNFLGQKRRMALLDVLLQSTIDGAPLSDEDIREEVDTFMFEGHDTTTSAISFCLYEIS 328
            ||..:.|...:.:...|.||..:.|.    ..|:.|::..:...|...|.||:.|.:.|.|||::
  Fly   255 ETVKQREEQGIVRSDFMNLLIEMKQR----GELTIEEMAAQAFIFFAAGFDTSASTLGFALYELA 315

  Fly   329 RHPEVQQRLQQEIRDVL----GEDRKSPVTLRDLGELKFMENVIKESLRLHPPVPMIGRWFAEDV 389
            :.|.:|.:|::||...|    ||     .|...:.||::||.||.|:||.:|.:|.:.|......
  Fly   316 KQPALQAKLREEIDQALRLHNGE-----FTYDSMQELRYMELVIAETLRKYPILPQLTRISRHLY 375

  Fly   390 EIRGK---HIPAGTNFTMGIFVLLRDPEYFESPDEFRPERFDAD-VPQIHPYAYIPFSAGPRNCI 450
            ..:|.   :|..|....:.::.:..||..:..|.:|.||||.|| :.|....|::||..||||||
  Fly   376 AAKGDRHFYIEPGQMLLIPVYGIHHDPALYPEPHKFIPERFLADQLAQRPTAAWLPFGDGPRNCI 440

  Fly   451 GQKFAMLEMKSTVSKLLR--HFELLPLGPEPRHSM---NIVLRSANGVHL 495
            |.:|..::....:..|||  ||.:.| ..:|:...   ||:|..|||::|
  Fly   441 GMRFGKMQTTIGLVSLLRNFHFSVCP-RTDPKIEFLKSNILLCPANGIYL 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d2	NP_001284806.1	p450	32..495	CDD:278495	128/531 (24%)
Cyp6a22	NP_001286431.1	p450	35..491	CDD:278495	129/533 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910