DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4d2 and cyp3c3

DIOPT Version :9

Sequence 1:	NP_001284806.1	Gene:	Cyp4d2 / 31192	FlyBaseID:	FBgn0011576	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001007401.2	Gene:	cyp3c3 / 492759	ZFINID:	ZDB-GENE-041114-102	Length:	503	Species:	Danio rerio

Alignment Length:	534	Identity:	141/534 - (26%)
Similarity:	245/534 - (45%)	Gaps:	76/534 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LGVVGVLLLVAFATLLLWDFLW-----RRRGNGILPGPRPLPFLGNLLMYRGLDPEQIMDFVKKN 61
            |.|...|:.:.. |||....:|     ::.|   :|||||.||.|..|.|    .:...:|..:.
Zfish     7 LSVTWTLVFLVI-TLLYMYGVWPHGFFKKLG---IPGPRPWPFFGTFLSY----TKGFFNFDMEC 63

  Fly    62 QRKYGRLYRVWILHQLAVFSTDPRDIEFVLSSQQHITKNNLYKL---LNCWLGDGLLMSTGRKWH 123
            .:|||:::.::......:..||...|:.::..:.:.|..|..::   |...|.||:......:|.
Zfish    64 AKKYGKVWGIYDGRLPILMVTDLEMIKTIMVKECYSTFTNRREVNVDLAGPLADGISAVKDERWK 128

  Fly   124 GRRKIITPTFHFKILEQFVEIFDQQSAVMVEQLQSRADGMTPINIFPVICLTALDIIAETAMGTK 188
            ..|..::|.|....|::...|....:...::.:|.| |...|:.|..|:...:||::..::....
Zfish   129 RIRGTLSPYFTSGRLKEIFPIAMTHADRFIKNMQKR-DHEQPVKIKEVVAPYSLDVVTSSSFSVD 192

  Fly   189 INAQKNPNLPYVQAVND-------------------VTNILIKRFIHAWQRVDWIFRLTQPTEAK 234
            |::..||:.|:|..:.:                   :.|:|.|..|..:.|....|..|...:.|
Zfish   193 IDSINNPDDPFVTNIKNFLKFSLFSPLILFLTLFPSIANLLGKMGISVFSRSIMNFFYTALRKIK 257

  Fly   235 RQDKAIKVMHDFTENIIRERRETLVNNSKETTPEEEVNFLGQKRRMALLDVLLQSTIDGAPLSDE 299
            .:.|......||...:|:.:...  :.:|:||.|:.|.                      .|:|.
Zfish   258 DEHKDSNGRVDFLRLMIQNQIPD--DQAKDTTSEQPVK----------------------GLTDH 298

  Fly   300 DIREEVDTFMFEGHDTTTSAISFCLYEISRHPEVQQRLQQEIRDVLGEDRKSPVTLRDLGELKFM 364
            :|..:...|:..|::||::.:||.|:.::.:|:..::|.:||......|  :|::...|.::.::
Zfish   299 EILSQSFIFILGGYETTSTTLSFLLHNLATNPDCLEKLVEEIDKNFPLD--TPISYDALMKMDYL 361

  Fly   365 ENVIKESLRLHPPVPMIGRWFAEDVEIRGKHIPAGTNFTMGIFVLLRDPEYFESPDEFRPERFDA 429
            |..|.||:||.|..|.:.|...:.||:.|..||..|...:..:||.|||:.::||.|||||||..
Zfish   362 EMSINESMRLLPTAPRLERVCKKTVELNGITIPKDTLVAIPTYVLNRDPQLWDSPQEFRPERFSP 426

  Fly   430 D-VPQIHPYAYIPFSAGPRNCIGQKFAMLEMKSTVSKLLRHFEL-------LPLGPEPRHSMNIV 486
            : ..:...||::||..|||||||.:||::.:|..|.|||::|.|       :||...|      |
Zfish   427 ENKSEFLQYAFMPFGLGPRNCIGMRFALMIVKLLVVKLLQNFSLETCKETQIPLELTP------V 485

  Fly   487 LRSANGVHLGLKPR 500
            .:....:.|.|.||
Zfish   486 FQPKVPITLKLTPR 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d2	NP_001284806.1	p450	32..495	CDD:278495	129/492 (26%)
cyp3c3	NP_001007401.2	p450	38..496	CDD:278495	130/494 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810