DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4d2 and Cyp4p1

DIOPT Version :9

Sequence 1:	NP_001284806.1	Gene:	Cyp4d2 / 31192	FlyBaseID:	FBgn0011576	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_524828.1	Gene:	Cyp4p1 / 45524	FlyBaseID:	FBgn0015037	Length:	513	Species:	Drosophila melanogaster

Alignment Length:	517	Identity:	180/517 - (34%)
Similarity:	283/517 - (54%)	Gaps:	35/517 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLVAFATLLLW-----------DFLWR--RRGNG-----ILPGPRPLPFLGNLLMYRGLDPEQIM 55
            |::|.:.||.|           .|..:  |..:|     |.|..:.....||.|...|.|...:.
  Fly     6 LILALSALLYWLHRANKDYHILSFFTKRIRLKDGTPVEIIAPIAKGKTIFGNTLDLYGRDHAGVF 70

  Fly    56 DFVKKNQRKYGRLYRVWILHQLAVFSTDPRDIEFVLSSQQHITKNNLYKLLNCWLGDGLLMSTGR 120
            ::.::..::.|..|..::..:......|....|.||:....|||..:|..|:.:|..|||.|||:
  Fly    71 NYSRERAKEMGTSYIEYVFGKAIYNIIDADSAENVLNHPNLITKGLVYNFLHPFLRTGLLTSTGK 135

  Fly   121 KWHGRRKIITPTFHFKILEQFVEIFDQQSAVMVEQLQSRADGMTPINIFPVICLTALDIIAETAM 185
            |||.|||::||||||.||.||.|||..:|...:.|.:.: |.:| |.:..||....|:.|.||||
  Fly   136 KWHARRKMLTPTFHFNILNQFQEIFKTESQKFLLQFEGQ-DEVT-ITLHDVIPRFTLNSICETAM 198

  Fly   186 GTKINAQKNPNLPYVQAVNDVTNILIKRFIHAWQRVDWIFRLTQPTEAKRQDKAIKVMHDFTENI 250
            |.|::........|.:..:.:....|:|..:.   :.|..:|.:...||....|:.|:|.|:..|
  Fly   199 GVKLDEMAEKGDRYRENFSQIEECFIRRLSNP---LLWGDKLFEMFAAKDFASALDVVHRFSSEI 260

  Fly   251 IRERRETLVNN-SKETTPEEEVNFLGQKRRMALLDVLLQSTIDGAPLSDE-DIREEVDTFMFEGH 313
            |.:||:.|.:. .|.::..::..|: .|:|.|:||.|:.:..||  |.|. .|.|||||.||||:
  Fly   261 IAKRRDLLKDELDKSSSTADDDGFV-SKKRFAMLDTLIYAEKDG--LIDHIGICEEVDTLMFEGY 322

  Fly   314 DTTTSAISFCLYEISRHPEVQQRLQQEIRDVLGEDRKSPVTLRDLGELKFMENVIKESLRLHPPV 378
            |||:..:.|.|..:|.:|:.|:...|||::.:.:| .|.:.:..|.:||::|..:||:.||.|.|
  Fly   323 DTTSIGLIFGLMNMSLNPDKQELCYQEIQEHIDDD-LSNLDVGQLNKLKYLEYFMKETTRLFPSV 386

  Fly   379 PMIGRWFAEDVEI-RGKHIPAGTNFTMGIFVLLRDPEYFESPDEFRPERF-DADVPQIHPYAYIP 441
            |::||...::.|: .|..:|.|...|:.:|.:.|:.:|::||:||||||| ..:|...|.|||:|
  Fly   387 PIMGREAVQETELANGLILPKGAQITIHVFDIHRNAKYWDSPEEFRPERFLPENVQDRHTYAYVP 451

  Fly   442 FSAGPRNCIGQKFAMLEMKSTVSKLLRHFELL-PLGPEP--RHSMNIVLRSANGVHLGLKPR 500
            ||||.|||||:|:||.|||:.:..||:.|::| .:.|:.  .|: .|.||:.:.:.:.|..|
  Fly   452 FSAGQRNCIGKKYAMQEMKTLMVVLLKQFKVLKAIDPQKIVFHT-GITLRTQDKIRVKLVRR 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d2	NP_001284806.1	p450	32..495	CDD:278495	169/469 (36%)
Cyp4p1	NP_524828.1	p450	54..509	CDD:278495	168/464 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460498
Domainoid	1	1.000	151	1.000	Domainoid score	I1385
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D10482at33392
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	9	9.000