DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4d2 and Cyp4c3

DIOPT Version :9

Sequence 1:	NP_001284806.1	Gene:	Cyp4d2 / 31192	FlyBaseID:	FBgn0011576	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_524598.1	Gene:	Cyp4c3 / 43663	FlyBaseID:	FBgn0015032	Length:	535	Species:	Drosophila melanogaster

Alignment Length:	523	Identity:	209/523 - (39%)
Similarity:	322/523 - (61%)	Gaps:	44/523 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 VGVLLLVAFATLLLWDFLWRRRGNGI------LPGPRPLPFLGNLLMYRGLDPEQIMDFVKKNQR 63
            :.|.||   .::|::..::.:|.:.:      :|||..:|||||.: ...:|.:::.:.|...|:
  Fly    29 ITVFLL---GSILIFLVVYNKRRSRLVKYIEKIPGPAAMPFLGNAI-EMNVDHDELFNRVIGMQK 89

  Fly    64 KYGR---LYRVWILHQLAVFSTDPRDIEFVLSSQQHITKNNLYKLLNCWLGDGLLMSTGRKWHGR 125
            .:|.   :.|||......|...:|..:|.:|:||:.:.|::.|..|:.|||:|||.||.||||.|
  Fly    90 LWGTRIGINRVWQGTAPRVLLFEPETVEPILNSQKFVNKSHDYDYLHPWLGEGLLTSTDRKWHSR 154

  Fly   126 RKIITPTFHFKILEQFVEIFDQQSAVMVEQLQSRADGMTPINIFPVICLTALDIIAETAMGTKIN 190
            |||:||.||||||:.|:::|::||||:..:|.... |....|:||.:.|..|||:.|||||.:|.
  Fly   155 RKILTPAFHFKILDDFIDVFNEQSAVLARKLAVEV-GSEAFNLFPYVTLCTLDIVCETAMGRRIY 218

  Fly   191 AQKNPNLPYVQAVNDVTNILIKRFIHAWQRVDWIFRLTQPTEAKRQDKAIKVMHDFTENIIRERR 255
            ||.|....||:||..:.:|:..|....|.:.|:||.||  .|.|.....|..:|.|:..:||||:
  Fly   219 AQSNSESEYVKAVYGIGSIVQSRQAKIWLQSDFIFSLT--AEYKLHQSYINTLHGFSNMVIRERK 281

  Fly   256 ETLV-----NNSKETTPEEEVNFLGQKRRMALLDVLLQSTIDGAPLSDEDIREEVDTFMFEGHDT 315
            ..|.     ||:......:..:.:|:|:|:|.||:|:.::.:|..||:|||||||||||||||||
  Fly   282 AELAILQENNNNNNNNAPDAYDDVGKKKRLAFLDLLIDASKEGTVLSNEDIREEVDTFMFEGHDT 346

  Fly   316 TTSAISFCLYEISRHPEVQQRLQQEIRDVLGEDRKSPVTLRDLGELKFMENVIKESLRLHPPVPM 380
            |::|||:.|:.:..|||.|:|:.:|:..:.|:|:::|.|:::|.:::::|..||:||||.|.|||
  Fly   347 TSAAISWTLFLLGCHPEYQERVVEELDSIFGDDKETPATMKNLMDMRYLECCIKDSLRLFPSVPM 411

  Fly   381 IGRWFAEDVEIRGKHIPAGTNFTMGIFVLLRDPEYFESPDEFRPERFDADVPQ----IHPYAYIP 441
            :.|...|||.|.||.:||||...:..:.|.|:|..|..|::|.|:.|   :|:    .||:||||
  Fly   412 MARMVGEDVNIGGKIVPAGTQAIIMTYALHRNPRVFPKPEQFNPDNF---LPENCAGRHPFAYIP 473

  Fly   442 FSAGPRNCIGQKFAMLEMKSTVSKLLRHF---------ELLPLGPEPRHSMNIVLRSANGVHLGL 497
            ||||||||||||||:||.|:.:|.:||.:         :|..||       .::||..:|:.:.:
  Fly   474 FSAGPRNCIGQKFAILEEKAVISTVLRKYKIEAVDRREDLTLLG-------ELILRPKDGLRVKI 531

  Fly   498 KPR 500
            .||
  Fly   532 TPR 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d2	NP_001284806.1	p450	32..495	CDD:278495	202/483 (42%)
Cyp4c3	NP_524598.1	p450	59..531	CDD:278495	202/485 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460441
Domainoid	1	1.000	151	1.000	Domainoid score	I1385
eggNOG	1	0.900	-	-		E33208_3B9GY
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	11	10.800