Protein Alignment Cyp4d2 and cyp-25A3

DIOPT Version :10

• Sequence 1: NP_525043.1
• Gene: Cyp4d2 / 31192
• FlyBaseID: FBgn0011576
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_001040850.1
• Gene: cyp-25A3 / 4363046
• WormBaseID: WBGene00014697
• Length: 502
• Species: Caenorhabditis elegans
• Alignment Length: 536
• Identity: 148/536 - (27%)
• Similarity: 251/536 - (46%)
• Gaps: 87/536 - (16%)

  Fly     9 LLVAFATLLLWDFL-----WRRRGNGILPGPRPLPFLGNL--LMYR----GLDPEQIMDFVKKNQ 62
            :||:..:.:::..|     :|.||...|.||.|...:|||  ::.|    |.|..  .|:..|..
 Worm     9 ILVSLVSFIIYVILARKERFRLRGKIGLSGPEPHWLMGNLKQIIERKAKLGYDDS--YDWYNKLH 71

  Fly    63 RKYGRLYRVWILHQLAVFSTDPRDIEFVL---------SSQQHITKNNLYKLLNCWLGDGLLMST 118
            :::|..:.::...||.:..|:..||:.|.         .:...|.::|..|       :.||.:|
 Worm    72 KQFGETFGIYFGTQLNINITNEEDIKEVFIKNFSNFSDRTPPPIIEDNKLK-------ESLLQNT 129

  Fly   119 GRK-WHGRRKIITPTFHFKILEQFVEIFDQQSAVMVEQLQSRADGMTPINIFPVICLTALDIIAE 182
            ... |...|..|.|.|....::...|....:..:.:|.|:.:|......:|:.......||:|.:
 Worm   130 YESGWKHTRSAIAPIFSTGKMKAMHETIHSKVDLFLEILKEKASSGQKWDIYDDFQGLTLDVIGK 194

  Fly   183 TAMGTKINAQKNPN-LPYVQAVNDVTNILIK--RFIHAWQRVDWIFRLTQPTEAKRQDKAIKVMH 244
            .|.....|.|::.| :.||.|...:|||.|:  :.|    ...::|        ....|..||::
 Worm   195 CAFAIDSNCQRDRNDVFYVNARKFITNIDIRHSKII----STSFLF--------PELSKLWKVLY 247

  Fly   245 DFTENIIRERRETLVNNSKETTPEEEVNFLGQKRR-------MALLDVLLQSTID-GAPLSDEDI 301
            .||:  :.:....||         |.:..:.::||       :.||.:||....| ..|::.:::
 Worm   248 RFTD--LAKAEIPLV---------EGLADVYERRRGGEGSDSVDLLKLLLNREDDKSKPMTKQEV 301

  Fly   302 REEVDTFMFEGHDTTTSAISFCLYEISRHPEVQQRLQQEIRDVLGEDRKSPVTLRDLGELKFMEN 366
            .|....|:..|::||::|:::|.|.:|::|.|||:|.:||.:.   .....:|...:..:|:::.
 Worm   302 IENCFAFLLAGYETTSTAMTYCSYLLSKYPNVQQKLYEEIMEA---KENGGLTYDSIHNMKYLDY 363

  Fly   367 VIKESLRLHPPV-PMIGRWFAEDVEIRGKHIPAGTNFTMGIFVLL-----RDPEYFESPDEFRPE 425
            |.||:||.:||| ....|...:|:.|||:..|.|     .|.|.|     |:||.::||:||.||
 Worm   364 VYKETLRCYPPVIHFSNRRCLKDITIRGQFYPKG-----AIVVCLPHTVHRNPENWDSPEEFHPE 423

  Fly   426 RFDADVPQIHPYAYIPFSAGPRNCIGQKFAMLEMKSTVSKLLRHFEL------LPLGPEPRHSMN 484
            ||:....:.....:|||..|||.|:|.:||.:|.|:|::|||..|||      ..|.|:   ...
 Worm   424 RFENWEEKSSSLKWIPFGVGPRYCVGMRFAEMEFKTTIAKLLDTFELKQFEGEADLIPD---CNG 485

  Fly   485 IVLRSANGVHLGLKPR 500
            :::|..:.|.|.||||
 Worm   486 VIMRPKDPVRLHLKPR 501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d2	NP_525043.1	CYP4	66..495	CDD:410721	125/461 (27%)
cyp-25A3	NP_001040850.1	CYP3A-like	73..495	CDD:410678	124/462 (27%)