DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d2 and Cyp313a1

DIOPT Version :9

Sequence 1:	NP_001284806.1	Gene:	Cyp4d2 / 31192	FlyBaseID:	FBgn0011576	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_650368.1	Gene:	Cyp313a1 / 41759	FlyBaseID:	FBgn0038236	Length:	492	Species:	Drosophila melanogaster

Alignment Length:	489	Identity:	140/489 - (28%)
Similarity:	229/489 - (46%)	Gaps:	58/489 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLVAFATLLLWDFLWRRRGNGIL----PGPRPLPFLG----NLLMYRGLDPEQIMDFVKKNQRKY 65
            ||:|...|....|||.||....|    |||..||.||    |::.|:     :.:.|..|...||
  Fly     6 LLLAVGALFWIYFLWSRRRLYFLMLKIPGPIGLPILGSSLENIITYK-----RKLSFRTKYLNKY 65

  Fly    66 GRLYRVWILHQLAVFSTDPRDIEFVLSSQQ-HITKNNLYKLLNCWLGDGLLMSTGRKWHGRRKII 129
            |.....|:.....:.:.||:.:|.:.||.. |....::...:...:|:|||......|..|||..
  Fly    66 GSTILTWMGPVPFIVTRDPKVVEDIFSSPDCHNKSQHIVNAITSCMGNGLLGKQDPHWLDRRKHF 130

  Fly   130 TPTFHFKILEQFVEIFDQQSAVMVEQLQSRADGMTPINIFPVICLTALDIIAETAMGTKINAQ-- 192
            .|:|...:|..|..|||.::.|::..|.:..| ...|::.|.:...:..|.|:|.||:::...
  Fly   131 NPSFKQDLLLSFFHIFDAETKVLMNLLDTYVD-KGEIDVVPEMLRWSFKIAAQTTMGSEVKHDEH 194

  Fly   193 -KNPNL--PYVQAVNDVT-NILI----KRFIHAWQRVDWIFRLTQPTEAKRQDKAIKVMHDFTEN 249
             ||.:|  .:...::..| |||:    .|.|......|.:          |.|...:: ....:|
  Fly   195 FKNGSLVESFESLISHSTLNILMPLVQNRMISKICGYDKL----------RADNFSRI-QKMLDN 248

  Fly   250 IIRERRETLVNNSKETTPEEEVNFLGQKRRMALL---DVLLQSTIDGAPLSDEDIREEVDTFMFE 311
            ::.::    ||...:|..:.|.|.: ..|.|.|.   |:...           |::.|....:..
  Fly   249 VVNKK----VNPLPKTDSDPESNIV-INRAMELYRKGDITYM-----------DVKSECCIMIAA 297

  Fly   312 GHDTTTSAISFCLYEISRHPEVQQRLQQEIRDVLGEDRKSPVTLRDLGELKFMENVIKESLRLHP 376
            |:||:...:...|:.::.|||.|:.:.:|:..|..:.....:|..|:.:|.::|.||||:|||.|
  Fly   298 GYDTSALTVYHALFLLANHPEHQEAVFEELNGVFPDAGHFGITYPDMQKLDYLERVIKETLRLIP 362

  Fly   377 PVPMIGRWFAEDVEI-RGKHIPAGTNFTMGIFVLLRDPEYF-ESPDEFRPERFDAD-VPQIHPYA 438
            .:|:..|....||.: .|..||.|....:.:|...|:||.: ...|.|.|:.|.|: :.|.||||
  Fly   363 AIPITARETKNDVRLSNGVLIPKGVVIGIDMFHTHRNPEVWGPDADNFNPDNFLAENMEQKHPYA 427

  Fly   439 YIPFSAGPRNCIGQKFAMLEMKSTVSKLLRHFEL 472
            ||||:.|.|||||.|:||:..|..:.::||::::
  Fly   428 YIPFARGKRNCIGSKYAMMSSKFALCRILRNYKI 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d2	NP_001284806.1	p450	32..495	CDD:278495	130/462 (28%)
Cyp313a1	NP_650368.1	p450	33..463	CDD:299894	130/462 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I1781
eggNOG	1	0.900	-	-		E33208_3B9GY
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	5	4.860