DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d2 and CYP4F3

DIOPT Version :9

Sequence 1:	NP_001284806.1	Gene:	Cyp4d2 / 31192	FlyBaseID:	FBgn0011576	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_000887.2	Gene:	CYP4F3 / 4051	HGNCID:	2646	Length:	520	Species:	Homo sapiens

Alignment Length:	516	Identity:	184/516 - (35%)
Similarity:	285/516 - (55%)	Gaps:	41/516 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VLLLVA----FATLLLWDFLWRRRGNGILPGPRPLP----FLGNLLMYRGL--DPEQIMDFVKKN 61
            :||||.    .|.:|.|.:.:......:...|:| |    |||:|    ||  ..|:.:.:.:..
Human    21 LLLLVGASWLLARILAWTYTFYDNCCRLRCFPQP-PKRNWFLGHL----GLIHSSEEGLLYTQSL 80

  Fly    62 QRKYGRLYRVWI--LHQLA-VFSTDPRDIEFVLSSQQHITKNN--LYKLLNCWLGDGLLMSTGRK 121
            ...:|.:...|:  .|.:. :|  .|..|:.||.:...|...:  .|..|..|||||||:|.|.|
Human    81 ACTFGDMCCWWVGPWHAIVRIF--HPTYIKPVLFAPAAIVPKDKVFYSFLKPWLGDGLLLSAGEK 143

  Fly   122 WHGRRKIITPTFHFKILEQFVEIFDQQSAVMVEQLQSRA-DGMTPINIFPVICLTALDIIAETAM 185
            |...|:::||.|||.||:.:::||::...:|..:.|..| :|...:::|..|.|..||.:.:...
Human   144 WSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSARLDMFEHISLMTLDSLQKCVF 208

  Fly   186 GTKINAQKNPNLPYVQAVNDVTNILIKRFIHAWQRVDWIFRLTQPTEAKRQDKAIKVMHDFTENI 250
            ....:.|:.|: .|:.|:.:::.::.||.......:|:::.||  .:.:|..:|.:::||||:.:
Human   209 SFDSHCQEKPS-EYIAAILELSALVTKRHQQILLYIDFLYYLT--PDGQRFRRACRLVHDFTDAV 270

  Fly   251 IRERRETLVNNSKETTPEEEV-NFLGQKRRMALLD----VLLQSTIDGAPLSDEDIREEVDTFMF 310
            |:|||.||        |.:.| :||..|.:...||    :||....||..|||||||.|.|||||
Human   271 IQERRRTL--------PSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMF 327

  Fly   311 EGHDTTTSAISFCLYEISRHPEVQQRLQQEIRDVLGEDRKSPVTLRDLGELKFMENVIKESLRLH 375
            ||||||.|.:|:.||.:::|||.|:|.:||::::|.:.....:...||.:|.|:...||||||||
Human   328 EGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCIKESLRLH 392

  Fly   376 PPVPMIGRWFAEDVEI-RGKHIPAGTNFTMGIFVLLRDPEYFESPDEFRPERFD-ADVPQIHPYA 438
            ||||.:.|...:|:.: .|:.||.|....:.:|....:|..:..|:.:.|.||| .::.:..|.|
Human   393 PPVPAVSRCCTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPKNIKERSPLA 457

  Fly   439 YIPFSAGPRNCIGQKFAMLEMKSTVSKLLRHFELLPLGPEPRHSMNIVLRSANGVHLGLKP 499
            :|||||||||||||.|||.|||..:...|..|.:||...|||....:|||:..|:.|.::|
Human   458 FIPFSAGPRNCIGQAFAMAEMKVVLGLTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEP 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d2	NP_001284806.1	p450	32..495	CDD:278495	175/481 (36%)
CYP4F3	NP_000887.2	p450	52..515	CDD:365848	175/480 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154782
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.650