DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d2 and Cyp312a1

DIOPT Version :9

Sequence 1:	NP_001284806.1	Gene:	Cyp4d2 / 31192	FlyBaseID:	FBgn0011576	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001262008.1	Gene:	Cyp312a1 / 40005	FlyBaseID:	FBgn0036778	Length:	510	Species:	Drosophila melanogaster

Alignment Length:	491	Identity:	162/491 - (32%)
Similarity:	282/491 - (57%)	Gaps:	15/491 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LLLVAFATLLLWDFLWRRRGNGIL---PGPRPLPFLGNL-LMYRGLDPEQIMDFVKK-NQRKYGR 67
            |||:|.:..||:.|..:.|.:.:.   |.|..|||:|:| ::.:.:.|..:....:. |:..:..
  Fly     8 LLLLALSLYLLYVFERQSRIDRLTHKWPAPPALPFIGHLHILAKLVGPHPLRRATEMINEHLHDH 72

  Fly    68 LYRVWILHQLAVFSTDPRDIEFVLSSQQHITKNNLYKLLNCWLGDGLLMSTGRKWHGRRKIITPT 132
            ..::|:..:|.:...:|:||:.:.|:||.:.|.|.|::...||.:||..|...||..||||:.|.
  Fly    73 RAKLWMGTKLYLVDCNPKDIQALCSAQQLLQKTNDYRVFENWLCEGLFTSGFEKWSHRRKIVMPA 137

  Fly   133 FHFKILEQFVEIFDQQSAVMVEQLQSRADGMTPINIFPVICLTALDIIAETAMGTKINAQKNPNL 197
            |::.:::|||.:|::||.:::..:...|:....|:...:|....||.|.|||:|..:.:|.:...
  Fly   138 FNYTMIKQFVAVFEKQSRILLTNVAKFAESGDQIDFLQLISCFTLDTICETALGVSVGSQSSAKS 202

  Fly   198 PYVQAVNDVTNILIKRFIHAWQRVDWIFRLTQPTEAKRQDKAIKVMHDFTENIIRERRETL---V 259
            .|:.||..:..|:.||..:.:.|..:||:.|  :..||:.:.||.:|.|||.||::|.:.:   .
  Fly   203 EYLDAVKSILVIIDKRLKNIFYRNSFIFKRT--SHYKREQELIKTLHGFTEGIIQKRIDEINQDA 265

  Fly   260 NNSKETTPEEEVNFLGQKRRMALLDVLLQST-IDGAPLSDEDIREEVDTFMFEGHDTTTSAISFC 323
            .|....:.:.|::  |.||.:..||.||.|. .||.||:.:||||||||.:|.|.|.|.:.::|.
  Fly   266 ENRNYQSSDAELD--GVKRTLCFLDTLLLSKGPDGKPLTVKDIREEVDTIIFGGFDLTATTLNFF 328

  Fly   324 LYEISRHPEVQQRLQQEIRDVLGEDRKSPVTLRDLGELKFMENVIKESLRLHPPVPMIGRWFAED 388
            :|.::.|||.|||.::|:..|.|:|:..|:::..:.:|:|:|..|||:||::|..|:..|....:
  Fly   329 MYNMTLHPEHQQRCREEVWSVCGKDKSEPISIEQVRQLEFLEACIKETLRMYPSGPLTARKATAN 393

  Fly   389 VEIRGKHIPAGTNFTMGIFVLLRDPEYFESPDEFRPERFDADV-PQIHPYAYIPFSAGPRNCIGQ 452
            ..|....||.|::..:....:.|..::|..|..|:|:|:.... |:|....:|||.||.|:|:||
  Fly   394 CTINDFFIPKGSDVIISPIYMGRCKDFFPDPMVFKPDRWAIGAEPKIEATTFIPFMAGARSCMGQ 458

  Fly   453 KFAMLEMKSTVSKLLRHFELLPLGP-EPRHSMNIVL 487
            ::||:.:|..::.|||:|...|||. :.:..:|.|:
  Fly   459 RYAMVMLKMVLAHLLRNFLFEPLGERQVKLKLNFVI 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d2	NP_001284806.1	p450	32..495	CDD:278495	154/464 (33%)
Cyp312a1	NP_001262008.1	p450	35..505	CDD:278495	154/464 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449053
Domainoid	1	1.000	151	1.000	Domainoid score	I1385
eggNOG	1	0.900	-	-		E33208_3B9GY
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D214327at33208
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	10	9.900