DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d2 and Cyp4aa1

DIOPT Version :9

Sequence 1:	NP_001284806.1	Gene:	Cyp4d2 / 31192	FlyBaseID:	FBgn0011576	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_611067.2	Gene:	Cyp4aa1 / 36752	FlyBaseID:	FBgn0034053	Length:	510	Species:	Drosophila melanogaster

Alignment Length:	511	Identity:	172/511 - (33%)
Similarity:	277/511 - (54%)	Gaps:	38/511 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLGVVGVLLLVAFATL--LLWDFLWRRRGNGILPGPRPLPFLGNLLMYRGLDPEQIMDFVKKNQR 63
            :|.|:.:.:...:|||  .|...|...|    |.||..||||||.::.  .|.:.:.....|...
  Fly    20 ILLVISLSIYTFYATLNTYLRSVLLSLR----LTGPPSLPFLGNCMLV--TDKDLMRRCAGKAFD 78

  Fly    64 KYGRLYRVWILHQLAVFSTDPRDIEFVLSSQQHITKNNLYKLLNCWLGDGLLMSTGRKWHGRRKI 128
            .||.|.|:|:|........:|.|::.:|||::|..|...|:|::.:|||||:.|:|.||...|::
  Fly    79 LYGSLVRIWVLLFPFFAVLEPEDLQVILSSKKHTNKVFFYRLMHNFLGDGLITSSGSKWSNHRRL 143

  Fly   129 ITPTFHFKILEQFVEIFDQQSAVMVEQLQSRADGMTPINIFPVICLTALDIIAETAMGTKINAQK 193
            |.|.||..:||:|::.|...|..:.|.|.:.|.| |.|||...:....|||:.|..:|..|..:.
  Fly   144 IQPAFHHNLLEKFIDTFVDASQSLYENLDAEAVG-TEINIAKYVNNCVLDILNEAVLGVPIKKRG 207

  Fly   194 N-----PNLPYVQAVNDVTNILI-KRFIHAWQRVDWIFRLTQPTEAKRQDKAIKVMHDFTENIIR 252
            .     .:.|:.|.     .|:: .||...|..:|.|:..|:....:...|  |.::|||..:|:
  Fly   208 QDVAMMEDSPFRQG-----KIMMPARFTQPWLLLDGIYHWTKMANDELNQK--KRLNDFTRKMIQ 265

  Fly   253 ERRETLVNNSKETTPEEEVNFLGQKRRMALLDVLLQSTIDGAPLSDEDIREEVDTFMFEGHDTTT 317
            .||:...||:            |...|..|||.:::.:......::|||..|..|||..|.|:..
  Fly   266 RRRQIQNNNN------------GNSERKCLLDHMIEISESNRDFTEEDIVNEACTFMLAGQDSVG 318

  Fly   318 SAISFCLYEISRHPEVQQRLQQEIRDVLGEDRKSPVTLRDLGELKFMENVIKESLRLHPPVPMIG 382
            :|::|.|:.::::||.|.|...|:..:..:..::| |:.||.|:::||..|||:|||:|.||:|.
  Fly   319 AAVAFTLFLLTQNPECQDRCVLELATIFEDSNRAP-TMTDLHEMRYMEMCIKEALRLYPSVPLIA 382

  Fly   383 RWFAEDVEIRGKHIPAGTNFTMGIFVLLRDPEYFESPDEFRPERFDADVPQ-IHPYAYIPFSAGP 446
            |...|:|.:....:|||:|..:..:...|....:..|::|:||||..:..: .||||::||||||
  Fly   383 RKLGEEVRLAKHTLPAGSNVFICPYATHRLAHIYPDPEKFQPERFSPENSENRHPYAFLPFSAGP 447

  Fly   447 RNCIGQKFAMLEMKSTVSKLLRHFELLPLGPEP--RHSMNIVLRSANGVHLGLKPR 500
            |.|||.:||::|:|:.||:|||.::|||:..:.  ..:..|.||::.|:.:.||.|
  Fly   448 RYCIGNRFAIMEIKTIVSRLLRSYQLLPVTGKTTIAATFRITLRASGGLWVRLKER 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d2	NP_001284806.1	p450	32..495	CDD:278495	160/471 (34%)
Cyp4aa1	NP_611067.2	p450	50..475	CDD:278495	154/447 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460465
Domainoid	1	1.000	151	1.000	Domainoid score	I1385
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	102	1.000	Inparanoid score	I1639
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	10	9.900