DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d2 and Cyp6a19

DIOPT Version :9

Sequence 1:	NP_001284806.1	Gene:	Cyp4d2 / 31192	FlyBaseID:	FBgn0011576	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_611001.2	Gene:	Cyp6a19 / 36662	FlyBaseID:	FBgn0033979	Length:	503	Species:	Drosophila melanogaster

Alignment Length:	545	Identity:	139/545 - (25%)
Similarity:	244/545 - (44%)	Gaps:	99/545 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLG-VVGVLLLVAFATLLLWDFLWRRRGNGILPGPRPLPFLGN------LLMYRGLDPEQIMDFV 58
            :|| |||||.|||:..|..:.: |:|||   :|...|...|||      .:...|:.....:.|.
  Fly     4 LLGLVVGVLTLVAWWVLQNYTY-WKRRG---IPHDPPNIPLGNTGELWRTMPLAGILKRTYLKFR 64

  Fly    59 KKNQRKYGRLYRVWILHQLAVFSTDPRDIEFVLS------------SQQHITKNNLYKLLNCWLG 111
            |:....:...| ::.:..:.:     .|::||.:            ...|..|::.       |.
  Fly    65 KQTDGPFAGFY-LYAMKYIVI-----TDVDFVKTVLIRDFDKFHDRGVYHNEKDDP-------LT 116

  Fly   112 DGLLMSTGRKWHGRRKIITPTF-HFKILEQF---VEIFDQQSAVMVEQLQSRADGMTPINIFPVI 172
            :.|....|:||...|:.:|.|| ..|:...|   :.:.|:...|:.|::.|.:.   .:.:..::
  Fly   117 NNLATIEGQKWKNLRQKLTHTFTSAKMKSMFSTVLNVGDEMIRVVDEKISSSSQ---TLEVTDIV 178

  Fly   173 CLTALDIIAETAMGTKINAQKNPNLPYVQAVNDVTNILIKRFIHAWQRVDWI------------F 225
            .....|:|...|.|.|.|:.::|...:||    :....::...|.| .||.:            |
  Fly   179 SRFTSDVIGICAFGLKCNSLRDPKAEFVQ----MGYSALRERRHGW-LVDLLIFGMPKLAVKLGF 238

  Fly   226 RLTQPTEAKRQDKAIKVMHDFTENIIRERRETLVNNSKETTPEEEVNF-LGQKRR-MALLDVLLQ 288
            :...|:..|...|.::...|:     |.:|:...|:..:|..:.:..: .|.|.. :|..:|..|
  Fly   239 QFLLPSVQKFYMKIVQDTIDY-----RMKRKVTRNDFMDTLIDMKQQYDKGDKENGLAFNEVAAQ 298

  Fly   289 STIDGAPLSDEDIREEVDTFMFEGHDTTTSAISFCLYEISRHPEVQQRLQQEIRDVLGEDRKSPV 353
            :.:                |...|.:..::.:.|.|||::.:.:||.:|:.||..|| |.....:
  Fly   299 AFV----------------FFLAGFEAGSTTMGFTLYELACNQDVQDKLRAEIDSVL-ERYNGKL 346

  Fly   354 TLRDLGELKFMENVIKESLRLHPPVPMIGRWFAEDVEIRGKH------IPAGTNFTMGIFVLLRD 412
            ....:.:|.:||.||.||||.||.|..:.|...:..:    |      |.|||...:....:..|
  Fly   347 EYDSMQDLFYMEKVINESLRKHPVVAHLARIATKPYQ----HSNPKYFIEAGTGVLVSTLGIHHD 407

  Fly   413 PEYFESPDEFRPERFDADVPQIHP-YAYIPFSAGPRNCIGQKFAMLEMKSTVSKLLRH--FELLP 474
            ||::..|::|.|||||.:..:..| .|::||.||||||||.:|..:::...::.|:.:  |||.|
  Fly   408 PEFYPEPEKFIPERFDEEQVKKRPTCAFLPFGAGPRNCIGLRFGRMQVIIGLALLIHNFRFELHP 472

  Fly   475 LGPEP-RHSM-NIVLRSANGVHLGL 497
            ..|.| :::: |::|.|..|:||.:
  Fly   473 KTPVPMKYTINNLLLGSEGGIHLNI 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d2	NP_001284806.1	p450	32..495	CDD:278495	122/509 (24%)
Cyp6a19	NP_611001.2	p450	32..495	CDD:278495	122/509 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810