DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4d2 and Cyp9h1

DIOPT Version :9

Sequence 1:	NP_001284806.1	Gene:	Cyp4d2 / 31192	FlyBaseID:	FBgn0011576	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_610820.1	Gene:	Cyp9h1 / 36412	FlyBaseID:	FBgn0033775	Length:	518	Species:	Drosophila melanogaster

Alignment Length:	549	Identity:	144/549 - (26%)
Similarity:	241/549 - (43%)	Gaps:	91/549 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VLLLVAFATLLLWDFLW--------RRRGNGILPGPRPLPFLGNL---LMYRGLDPEQIMDFVKK 60
            ::.|..|..||:..:.|        ..||   :...:|.|.:||:   .|..|      |..:||
  Fly     5 MIALALFIILLVLLYKWSVAKYDVFSERG---VSHEKPWPLIGNIPLKAMIGG------MPVLKK 60

  Fly    61 -----NQRKYGRLYRVWILHQLAVFSTDPRDIE---------FVLSSQQHITKNNLYKLLNCWLG 111
                 .:.....:|.::.|.....|..||..|:         ||..:..|   ||:.:.:   |.
  Fly    61 MIELHTKHTGSPVYGIYALRDAVFFVRDPELIKLIGIKEFDHFVNHNSMH---NNIQESI---LS 119

  Fly   112 DGLLMSTGRKWHGRRKIITPTF---HFKILEQFVEIFDQQSAVMV-EQLQSRADGMTPINIFPVI 172
            ..|:.....:|...|.|:||.|   ..:|:...::...::..:.: |||:...|....:.:....
  Fly   120 KSLISLRDGRWKEMRNILTPAFTGSKMRIMYDLIQSCSEEGVIHIQEQLELSQDASIELEMKDYF 184

  Fly   173 CLTALDIIAETAMGTKINAQKNPNLPYV---QAVNDVTNILIKRFIHAWQRVDWIFRLTQPTEAK 234
            ...|.|:||..|.|..||:.:..:..:.   ||::.::         ||..|..:.....|
  Fly   185 TRFANDVIATVAFGISINSFRRKDNEFFRIGQAMSRIS---------AWSVVKAMLYALFP---- 236

  Fly   235 RQDKAIKVMHDFTENI----------IRERRETLVNNSKETTPEEEVNFLGQKRRMALLDVLLQS 289
            |..|.:::....|:||          :|.|:|     .|...| :.::.|.:.::..|.| |...
  Fly   237 RLMKVLRIQVLDTKNIDYFSSLVTAAMRYRQE-----HKVVRP-DMIHLLMEAKQQRLAD-LSDK 294

  Fly   290 TIDGAPLSD---EDIREEVDTFMFEGHDTTTSAISFCLYEISRHPEVQQRLQQEIRDVLGEDRKS 351
            :.|....|:   :|:..:...|.|.|.:..:|::.|..:|:..:|.||.||.:||..|..|.:..
  Fly   295 SKDELYYSEFTADDLLAQCLLFFFAGFEIISSSLCFLTHELCLNPTVQDRLYEEIISVHEELKGQ 359

  Fly   352 PVTLRDLGELKFMENVIKESLRLHPPVPMIGRWFAEDVEI---RGKHI---PAGTNFTMGIFVLL 410
            |:|...|.::|:::.|:.|:||..||.....|...:|:::   .|:.:   ..|....:.||.|.
  Fly   360 PLTYDKLTKMKYLDMVVLEALRKWPPSISTDRECRQDIDLFDENGQKLFSARKGDVLQIPIFSLH 424

  Fly   411 RDPEYFESPDEFRPERFDADVPQIHPYAYIPFSAGPRNCIGQKFAMLEMKSTVSKLLRHFELLPL 475
            .|||.||.|:.|.|||| ||...:....|:||..|||||||.:.|::|:||.|.:||.:|:|||.
  Fly   425 HDPENFEDPEFFNPERF-ADGHALESRVYMPFGVGPRNCIGNRMALMELKSIVYQLLLNFKLLPA 488

  Fly   476 GPEPRHSMNIV----LRSANGVHLGLKPR 500
            ....|..:|.:    |:..||..|..:.|
  Fly   489 KRTSRDLLNDIRGHGLKPKNGFWLKFEAR 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d2	NP_001284806.1	p450	32..495	CDD:278495	135/509 (27%)
Cyp9h1	NP_610820.1	p450	38..512	CDD:278495	135/506 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810