DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d2 and Cyp46a1

DIOPT Version :9

Sequence 1:	NP_001284806.1	Gene:	Cyp4d2 / 31192	FlyBaseID:	FBgn0011576	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	XP_006240610.1	Gene:	Cyp46a1 / 362782	RGDID:	1306605	Length:	500	Species:	Rattus norvegicus

Alignment Length:	528	Identity:	153/528 - (28%)
Similarity:	255/528 - (48%)	Gaps:	76/528 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VVGVLLLVAFATLLLWDFLWRRRGN-GILPG-PRPLPFLGNLLMYRGLD-------PEQIMDFVK 59
            ::|..:|:||.  |...|:.|.|.. ..:|| |||...||:|..:...|       .:..:|:.|
  Rat     7 LLGSAVLLAFG--LCCTFVHRARSRYEHIPGPPRPSFLLGHLPYFWKKDEACGRVLQDVFLDWAK 69

  Fly    60 KNQRKYGRLYRVWILHQLAVFSTDPRDIEFVLSSQQHITKNNLYKLLNCWLGDGL----LMST-- 118
                |||.:.||.:.|:.:|..|.|..::..|.|.::...:.:|:.:....|:.|    |:|.
  Rat    70 ----KYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRAIQTVFGERLFGQGLVSECD 130

  Fly   119 -GRKWHGRRKIITPTFHFKILEQFVEIFDQQSAVMVEQLQSRADGMTPINIFPVICLTALDIIAE 182
             || |:.:|:::...|....|...:..|::::..::|.|:::|||.||:::..::....:||:|:
  Rat   131 YGR-WYKQRRVMDLAFSRSSLVSLMGTFNEKAEQLMEILEAKADGQTPVSMQDMLTCATIDILAK 194

  Fly   183 TAMGTK----INAQKNPNLPYVQAVNDV-------TNILIKRFIHAWQRVDWIFRLTQPTEAKRQ 236
            .|.|.:    :.|||    |..|||..:       .|.|.|            |...:..:.:..
  Rat   195 AAFGMETSMLLGAQK----PLSQAVKVMLEGISASRNTLAK------------FMPGKRKQLREI 243

  Fly   237 DKAIKVMHDFTENIIRERRETLVNNSKETTPEEEVNFLGQKRRMALLDVLLQ--STIDGAPLSDE 299
            .::|:::....::.::.|||.|...  |..|               .|:|.|  ...:||. .||
  Rat   244 RESIRLLRQVGKDWVQRRREALKRG--EDVP---------------ADILTQILKAEEGAQ-DDE 290

  Fly   300 DIREEVDTFMFEGHDTTTSAISFCLYEISRHPEVQQRLQQEIRDVLGEDRKSPVTLRDLGELKFM 364
            .:.:...||...||:|:.:.::|.:.|:||.||:..|||.|:.:|:|..|.  :...|||.|:::
  Rat   291 VLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVVGSKRH--LDYEDLGRLQYL 353

  Fly   365 ENVIKESLRLHPPVPMIGRWFAEDVEIRGKHIPAGTNFTMGIFVLLRDPEYFESPDEFRPERFDA 429
            ..|:||||||:||.....|...|:..|.|..:|..|......:|:.|...|||.|..|.|:||..
  Rat   354 SQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGP 418

  Fly   430 DVPQIHPYAYIPFSAGPRNCIGQKFAMLEMKSTVSKLLRHFELLPLGPEPRHSM--NIVLRSANG 492
            ..|:.. :.|.|||.|.|:||||:||.:|:|..::|||:..| ..|.|..|..:  ...|:..:.
  Rat   419 GAPKPR-FTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLE-FRLVPGQRFGLQEQATLKPLDP 481

  Fly   493 VHLGLKPR 500
            |...|:||
  Rat   482 VLCTLRPR 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d2	NP_001284806.1	p450	32..495	CDD:278495	142/492 (29%)
Cyp46a1	XP_006240610.1	p450	34..466	CDD:278495	139/474 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810