DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4d2 and Cyp4e2

DIOPT Version :9

Sequence 1:	NP_001284806.1	Gene:	Cyp4d2 / 31192	FlyBaseID:	FBgn0011576	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001286196.1	Gene:	Cyp4e2 / 35822	FlyBaseID:	FBgn0014469	Length:	526	Species:	Drosophila melanogaster

Alignment Length:	529	Identity:	211/529 - (39%)
Similarity:	309/529 - (58%)	Gaps:	52/529 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LLLVAFATLLLWDFLWRRRGNGILPGPRPLPFLGNLLMYRGLDPEQIMDFVKKNQRKYGR-LYRV 71
            |||||:..|..:.   |||......|||.||.:|| ....|.:|.:|:|.|.....:||: .:..
  Fly    13 LLLVAYLELSTFR---RRRVLNKFNGPRGLPLMGN-AHQMGKNPSEILDTVFSWWHQYGKDNFVF 73

  Fly    72 WILHQLAVFSTDPRDIEFVLSSQQHITKNNLYKLLNCWLGDGLLMSTGRKWHGRRKIITPTFHFK 136
            ||.....|..|..:.:||:||||..|||:::|:|.:.|||.|||.|||.|||..||:|||.|||.
  Fly    74 WIGTYSNVLVTSSKYLEFILSSQTLITKSDIYQLTHPWLGLGLLTSTGSKWHKHRKMITPAFHFN 138

  Fly   137 ILEQFVEIFDQQSAVMVEQLQSRADGMTPINIF----PVICLTALDIIAETAMGTKINAQKNPNL 197
            ||:.|.|:.::.|...::.|::.|.|   .|||    ....|| ||:|.:||||..|||.:|.:.
  Fly   139 ILQDFHEVMNENSTKFIKHLKTVAAG---DNIFDFQEQAHYLT-LDVICDTAMGVSINAMENRSS 199

  Fly   198 PYVQAVNDVTNILIKRFIHAWQRVDWIFRLTQPTEAKRQDKAIKVMHDFTENIIRERRETLVNNS 262
            ..|||..|:...:..|..|..:|.:.::||.....|  ..:.:|.:.|||..||.:|.|...:.:
  Fly   200 SIVQAFKDMCYNINMRAFHPLKRNELLYRLAPDYPA--YSRTLKTLQDFTNEIIAKRIEAHKSGA 262

  Fly   263 KETTPEEEVNFLGQKRRMALLDVLLQSTIDGAPLSDEDIREEVDTFMFEGHDTTTSAISFCLYEI 327
            ..|...:|..    :::||.||.||.|||||.||:.:::.|||.||||||||||||.:||.:|.:
  Fly   263 VSTNAGDEFT----RKKMAFLDTLLSSTIDGRPLNSKELYEEVSTFMFEGHDTTTSGVSFAVYLL 323

  Fly   328 SRHPEVQQRLQQEIRDVLGEDRKS-PVTLRDLGELKFMENVIKESLRLHPPVPMIGRWFAEDVEI 391
            |||.:.|::|.:|.|:|:|..... ..|.:::.::|:::..|||:.|::|.||.|||:..:|..|
  Fly   324 SRHQDEQRKLFKEQREVMGNSELGRDATFQEISQMKYLDLFIKEAQRVYPSVPFIGRFTEKDYVI 388

  Fly   392 RGKHIPAGTNFTMGIFVLLRDPEYFESPDEFRPERFDADVPQIHPYAYIPFSAGPRNCIGQKFAM 456
            .|..:|.||...:|:.:|..:.:.|:.|.:||||||:.:.|  .|:.|:|||||||||||||||:
  Fly   389 DGDLVPKGTTLNLGLVMLGYNEKVFKDPHKFRPERFELEKP--GPFEYVPFSAGPRNCIGQKFAL 451

  Fly   457 LEMKSTVSKLLRHFELLP---------------LG-PEP--------RH------SMNIVLRSAN 491
            ||:|:.|||::|:||:||               :| |:.        ||      |..:.|:|.|
  Fly   452 LEIKTVVSKIIRNFEVLPALDELVSKDGYISTTIGLPDAERKKRDPYRHKYDPILSAVLTLKSEN 516

  Fly   492 GVHLGLKPR 500
            |:::.||.|
  Fly   517 GLYIRLKER 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d2	NP_001284806.1	p450	32..495	CDD:278495	199/498 (40%)
Cyp4e2	NP_001286196.1	p450	35..469	CDD:278495	188/446 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449030
Domainoid	1	1.000	101	1.000	Domainoid score	I1781
eggNOG	1	0.900	-	-		E33208_3B9GY
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D10482at33392
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	11	10.800