Protein Alignment Cyp4d2 and CYP26C1

DIOPT Version :10

• Sequence 1: NP_525043.1
• Gene: Cyp4d2 / 31192
• FlyBaseID: FBgn0011576
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_899230.2
• Gene: CYP26C1 / 340665
• HGNCID: 20577
• Length: 522
• Species: Homo sapiens
• Alignment Length: 550
• Identity: 121/550 - (22%)
• Similarity: 217/550 - (39%)
• Gaps: 101/550 - (18%)

  Fly     1 MLGVVGVLLLVAFATLLLWDFLW-------RRRGNGI-LP-GPRPLPFLGNLLMYRGLDPEQIMD 56
            :||..|..||.|...|.|...||       |.|.:.: || |....||.|..|.:.    .|...
Human    11 VLGAAGTALLCAGLLLSLAQHLWTLRWMLSRDRASTLPLPKGSMGWPFFGETLHWL----VQGSR 71

  Fly    57 FVKKNQRKYGRLYRVWILHQLAVFSTDPRDIEFVLSSQQHITKNNLYKLLNCWLGD-GLLMSTGR 120
            |....:.:||.:::..:|.:..:..:...::..:|..:..:.::...:..:..||. .||.:.|.
Human    72 FHSSRRERYGTVFKTHLLGRPVIRVSGAENVRTILLGEHRLVRSQWPQSAHILLGSHTLLGAVGE 136

  Fly   121 KWHGRRKIITPTFHFKILEQFVEIFDQQSAVMVEQLQSRADGMTPINIFPVICLTALDIIAETAM 185
            ....|||::...|....||::|   .:....:..:::|......|::::.........:.|...:
Human   137 PHRRRRKVLARVFSRAALERYV---PRLQGALRHEVRSWCAAGGPVSVYDASKALTFRMAARILL 198

  Fly   186 GTKINAQKNPNL--PYVQAVNDVTNILIKRFIHAWQRVDWIFRLTQPTEAKRQD-KAIKVMHDFT 247
            |.:::..:...|  .:.|.|.::.::                .|..|....|:. :|...:|...
Human   199 GLRLDEAQCATLARTFEQLVENLFSL----------------PLDVPFSGLRKGIRARDQLHRHL 247

  Fly   248 ENIIRERRETLVNNSKETTPEEEVNFLGQKRRMALLDVLLQSTID-GAPLSDEDIREEVDTFMFE 311
            |..|.|:    ::..|...|.:            .||:::.|..: |...|.::::|.....:|.
Human   248 EGAISEK----LHEDKAAEPGD------------ALDLIIHSARELGHEPSMQELKESAVELLFA 296

  Fly   312 GHDTTTSAISFCLYEISRHPEVQQRLQQEI------------RDVLGEDRKSP--------VTLR 356
            ...||.||.:..:..:.:||....::::|:            ....|.....|        ::|.
Human   297 AFFTTASASTSLVLLLLQHPAAIAKIREELVAQGLGRACGCAPGAAGGSEGPPPDCGCEPDLSLA 361

  Fly   357 DLGELKFMENVIKESLRLHPPVPMIGRWFAEDVEIRGKHIPAGTNFTMGIFVLLRDPE-----YF 416
            .||.|::::.|:||.|||.|||....|......|:.|..||.|    ..:...:||..     |.
Human   362 ALGRLRYVDCVVKEVLRLLPPVSGGYRTALRTFELDGYQIPKG----WSVMYSIRDTHETAAVYR 422

  Fly   417 ESPDEFRPERFDA-------DVPQIHPYAYIPFSAGPRNCIGQKFAMLEMKSTVSKLLR--HFEL 472
            ..|:.|.||||.|       ...:.|   ||||..|.|:|:||:.|...::....:|:|  .:||
Human   423 SPPEGFDPERFGAAREDSRGASSRFH---YIPFGGGARSCLGQELAQAVLQLLAVELVRTARWEL 484

  Fly   473 -LPLGPEPRHSMNIV--LRSANGVHLGLKP 499
             .|..|    :|..|  :...:|:.|...|
Human   485 ATPAFP----AMQTVPIVHPVDGLRLFFHP 510

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d2	NP_525043.1	CYP4	66..495	CDD:410721	97/470 (21%)
CYP26C1	NP_899230.2	CYP26C1	59..508	CDD:410729	103/498 (21%)