DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d2 and Cyp4d21

DIOPT Version :9

Sequence 1:	NP_001284806.1	Gene:	Cyp4d2 / 31192	FlyBaseID:	FBgn0011576	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_609129.2	Gene:	Cyp4d21 / 34036	FlyBaseID:	FBgn0031925	Length:	511	Species:	Drosophila melanogaster

Alignment Length:	511	Identity:	230/511 - (45%)
Similarity:	326/511 - (63%)	Gaps:	21/511 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VVGVLLLVAFATLLLWD---FLWR---RRGNGILPGPRPLPFLGNLLMYRGLDPEQIMDFVKKNQ 62
            ::|:.:|:   ..|:||   ..||   ...:.|| ||..:|.:||.|....|.||..:.......
  Fly     4 LLGIAVLI---MTLVWDNSRKQWRVNTFEKSRIL-GPFTIPIVGNGLQALTLRPENFIQRFGDYF 64

  Fly    63 RKYGRLYRVWILHQLAVFSTDPRDIEFVLSSQQHITKNNLYKLLNCWLGDGLLMSTGRKWHGRRK 127
            .|||:.:|:|||.:..:::.|.:..|.:|||...:.|.:||:.|..:||||||:|||.||..|||
  Fly    65 NKYGKTFRLWILGECLIYTKDLKYFESILSSSTLLKKAHLYRFLRDFLGDGLLLSTGNKWTSRRK 129

  Fly   128 IITPTFHFKILEQFVEIFDQQSAVMVEQLQSRADGMTPINIFPVICLTALDIIAETAMGTKINAQ 192
            ::.|.||||.||.||||.|:.|.:|||:|::.|||.|.:::|..:.|.|||:..|||||.::|||
  Fly   130 VLAPAFHFKCLENFVEIMDRNSGIMVEKLKNYADGKTCVDLFKFVSLEALDVTTETAMGVQVNAQ 194

  Fly   193 KNPNLPYVQAVNDVTNILIKRFIHAWQRVDWIFRLTQPTEAKRQDKAIKVMHDFTENIIRERRET 257
            ..||.||.:|:..|..|..||......|.:|:|.|..|...:|..|.|.:|.|||:.:|||||..
  Fly   195 NEPNFPYTKALKSVVYIESKRLASVSMRYNWLFPLAAPLVYRRLQKDIAIMQDFTDKVIRERRAI 259

  Fly   258 LVNNSKETTPEEEV---NFLGQKRRMALLDVLLQSTIDGAPLSDEDIREEVDTFMFEGHDTTTSA 319
            |.....:.|.:..:   :.:|.|.:|.|||:|||:|||..||||.|||||||.|:|.|.|||||.
  Fly   260 LERARADGTYKPLIMGDDDIGGKAKMTLLDILLQATIDNKPLSDVDIREEVDVFIFAGDDTTTSG 324

  Fly   320 ISFCLYEISRHPEVQQRLQQEIRDVLGEDRKSPVTLRDLGELKFMENVIKESLRLHPPVPMIGRW 384
            :|..|:.|||||:||:.:.:|:..|||.|..:.||...|.|||:::.||||::|||||||::||:
  Fly   325 VSHALHAISRHPKVQECIYEELVSVLGPDPDASVTQTKLLELKYLDCVIKETMRLHPPVPILGRY 389

  Fly   385 FAEDVEIRGKHIPAGTNFTMGIFVLLRDPEYFESPDEFRPERF-----DADVPQIHPYAYIPFSA 444
            ..||::|....||..|:..:..:.:.||||||..|..|:|||:     .::.|   |.||||||:
  Fly   390 IPEDLKIGEITIPGNTSILLMPYYVYRDPEYFPDPLVFKPERWMDMKTTSNTP---PLAYIPFSS 451

  Fly   445 GPRNCIGQKFAMLEMKSTVSKLLRHFELLPLGPEPRHSMNIVLRSANGVHLGLKPR 500
            ||:||||||||.|:||:.:||::||:||||||.:.:.:...:|.|:.|.::|||||
  Fly   452 GPKNCIGQKFANLQMKALISKVIRHYELLPLGADLKATYTFILSSSTGNNVGLKPR 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d2	NP_001284806.1	p450	32..495	CDD:278495	216/470 (46%)
Cyp4d21	NP_609129.2	p450	35..482	CDD:278495	210/449 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449000
Domainoid	1	1.000	151	1.000	Domainoid score	I1385
eggNOG	1	0.900	-	-		E33208_3B9GY
Homologene	1	1.000	-	-		H82150
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28797
OrthoDB	1	1.010	-	-		D10482at33392
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	12	11.910