Protein Alignment Cyp4d2 and Cyp3a44

DIOPT Version :10

• Sequence 1: NP_525043.1
• Gene: Cyp4d2 / 31192
• FlyBaseID: FBgn0011576
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_796354.1
• Gene: Cyp3a44 / 337924
• MGIID: 2449818
• Length: 504
• Species: Mus musculus
• Alignment Length: 533
• Identity: 145/533 - (27%)
• Similarity: 256/533 - (48%)
• Gaps: 95/533 - (17%)

  Fly     8 LLLVAFATLLLWDF------LWRRRGNGILPGPRPLPFLGNLL-MYRGLDPEQIMDFVKKNQRKY 65
            |:|:|...:||:.:      |::::|   :|||:||||||.:| .|.|     |..|..:...||
Mouse    12 LVLLAIILVLLYRYGTRTHGLFKKQG---IPGPKPLPFLGTVLNYYTG-----IWKFDMECYEKY 68

  Fly    66 GRLYRVWILHQLAVFSTDPRDIEFVLSSQQHITKNNLYKLLN-------CWLGDGLLMSTGRKWH 123
            |:.:.::......:..|||..|:.||      .|:.|....|       ..:...:.:|...:|.
Mouse    69 GKTWGLFDGQTPLLVITDPETIKNVL------VKDCLSVFTNRREFGPVGIMSKAISISKDEEWK 127

  Fly   124 GRRKIITPTFHFKILEQFVEIFDQQSAVMVEQLQSRADGMTPINIFPVICLTALDIIAETAMGTK 188
            ..|.:::|||....|::...:.:|...::|:.|:..|:...|:.:..|:...::|:|..|:.|..
Mouse   128 RYRALLSPTFTSGRLKEMFPVIEQYGDILVKYLRQEAEKGMPVAMKDVLGAYSMDVITSTSFGVN 192

  Fly   189 INAQKNPNLPYVQAVNDVTNILIKRFIHAWQRVDW---------IFRLTQPTEAKRQ-----DKA 239
            :::..||..|:|:..        |:|:    |||:         :|.|..|......     :.:
Mouse   193 VDSLNNPEDPFVEEA--------KKFL----RVDFFDPLLFSVVLFPLLTPVYEMLNICMFPNDS 245

  Fly   240 IKVMHDFTENIIRERRETLVNNSKETTPEEEVNFLGQKRRMALLDVLLQSTIDG------APLSD 298
            |:....|.:.:...|.::                 .||.|:..|.:::.|..:.      ...|:
Mouse   246 IEFFKKFVDRMQESRLDS-----------------NQKHRVDFLQLMMNSHNNSKDKDSHKAFSN 293

  Fly   299 EDIREEVDTFMFEGHDTTTSAISFCLYEISRHPEVQQRLQQEIRDVLGEDRKSPVTLRDLGELKF 363
            .:|..:...|:..|::||:|.:||.||.::.||::|::||.||...|  ..|:..|...:.|:::
Mouse   294 MEITVQSIIFISAGYETTSSTLSFTLYCLATHPDIQKKLQAEIDKAL--PNKATPTCDTVMEMEY 356

  Fly   364 MENVIKESLRLHPPVPMIGRWFAEDVEIRGKHIPAGTNFTMGIFVLLRDPEYFESPDEFRPERFD 428
            ::.|:.|:|||:|.|..:.|...:|||:.|.:||.|:...:..:.|..||:::..|:||:||||.
Mouse   357 LDMVLNETLRLYPIVTRLERVCKKDVELNGVYIPKGSMVMIPSYALHHDPQHWPDPEEFQPERFS 421

  Fly   429 AD-VPQIHPYAYIPFSAGPRNCIGQKFAMLEMKSTVSKLLRHFELLP---------------LGP 477
            .: ...|.||.|:||..|||||||.:||::.||..|:|:|::|...|               |.|
Mouse   422 KENKGSIDPYVYLPFGIGPRNCIGMRFALMNMKLAVTKVLQNFSFQPCQETQIPLKLSRQGILQP 486

  Fly   478 EPRHSMNIVLRSA 490
            |....:.:|.|.|
Mouse   487 EKPIVLKVVPRDA 499

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d2	NP_525043.1	CYP4	66..495	CDD:410721	122/468 (26%)
Cyp3a44	NP_796354.1	CYP3A	67..493	CDD:410743	121/462 (26%)