DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d2 and Cyp4f39

DIOPT Version :9

Sequence 1:	NP_001284806.1	Gene:	Cyp4d2 / 31192	FlyBaseID:	FBgn0011576	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_796281.1	Gene:	Cyp4f39 / 320997	MGIID:	2445210	Length:	532	Species:	Mus musculus

Alignment Length:	524	Identity:	174/524 - (33%)
Similarity:	277/524 - (52%)	Gaps:	48/524 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VVGVLLLVAF--------ATLLLWDFLWRRRGNGILPGPRPLP----FLGNLLMY----RGLDPE 52
            |..:||||.|        |..|..||....|.....|.|   |    .||::.||    :||..|
Mouse    24 VSALLLLVLFFFFRLLVRAFKLFSDFRITCRKLSCFPEP---PGRHWLLGHMSMYLPNEKGLQNE 85

  Fly    53 -QIMDFVKKNQRKYGRLYRVWI---LHQLAVFSTDPRDIEFVLSSQQHITKNN--LYKLLNCWLG 111
             :::|.:.       .:...|:   |..|.:  ..|..|:.||.:...|...:  .|..|..|||
Mouse    86 KKVLDTMH-------HIILAWVGPFLPLLVL--VHPDYIKPVLGASAAIAPKDEFFYSFLKPWLG 141

  Fly   112 DGLLMSTGRKWHGRRKIITPTFHFKILEQFVEIFDQQSAVM-VEQLQSRADG-MTPINIFPVICL 174
            ||||:|.|.||...|:::||.|||.||:.:::||:|.:.:| .:..:..|:| :|..::|..|.|
Mouse   142 DGLLISKGNKWSRHRRLLTPAFHFDILKPYMKIFNQCTNIMHAKWRRHLAEGSVTSFDMFEHISL 206

  Fly   175 TALDIIAETAMGTKINAQKNPNLPYVQAVNDVTNILIKRFIHAWQRVDWIFRLTQPTEAKRQDKA 239
            ..||.:.:.......:.|:..: .|:.::.:::.::::|.......:|:::.||  .:.:|..:|
Mouse   207 MTLDSLQKCVFSYNSDCQERMS-DYISSIIELSALVVRRQYRLHHYLDFMYYLT--ADGRRFRQA 268

  Fly   240 IKVMHDFTENIIRERRETLVNNSKETTPEEEVNFLGQKRRMALLDV-LLQSTIDGAPLSDEDIRE 303
            ...:|:||..:|:|||:.|.....|...:.:     |.:.:..:|| ||....:|..|||||||.
Mouse   269 CDTVHNFTTEVIQERRQALRQQGAEAWLKAK-----QGKTLDFIDVLLLAKDEEGKELSDEDIRA 328

  Fly   304 EVDTFMFEGHDTTTSAISFCLYEISRHPEVQQRLQQEIRDVLGEDRKSPVTLRDLGELKFMENVI 368
            |.|||||||||||:|.:|:.|:.::::||.|::.::||::|:.......:...||.:|.|....|
Mouse   329 EADTFMFEGHDTTSSGLSWALFNLAKYPEYQEKCREEIQEVMKGRELEELDWDDLTQLPFTTMCI 393

  Fly   369 KESLRLHPPVPMIGRWFAEDVEI-RGKHIPAGTNFTMGIFVLLRDPEYFESPDEFRPERFDADVP 432
            |||||..|||.:|.|...||::: .|:.||.|....:.|:....:|..:.....:.|.|||.|.|
Mouse   394 KESLRQFPPVTLISRRCTEDIKLPDGRVIPKGIICLVSIYGTHHNPIVWPDSKVYNPYRFDPDTP 458

  Fly   433 QIH-PYAYIPFSAGPRNCIGQKFAMLEMKSTVSKLLRHFEL-LPLGPEPRHSMNIVLRSANGVHL 495
            |.. |.|::||||||||||||.|||.||:..|:..|..|.| :....:.|....::||:.||:.|
Mouse   459 QQRSPLAFVPFSAGPRNCIGQSFAMAEMRVVVALTLLRFRLSVDRTHKVRRKPELILRTENGLWL 523

  Fly   496 GLKP 499
            .::|
Mouse   524 NVEP 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d2	NP_001284806.1	p450	32..495	CDD:278495	161/482 (33%)
Cyp4f39	NP_796281.1	p450	60..515	CDD:365848	157/474 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844902
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.650