DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d2 and Cyp20a1

DIOPT Version :9

Sequence 1:	NP_001284806.1	Gene:	Cyp4d2 / 31192	FlyBaseID:	FBgn0011576	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_955433.1	Gene:	Cyp20a1 / 316435	RGDID:	735221	Length:	462	Species:	Rattus norvegicus

Alignment Length:	512	Identity:	116/512 - (22%)
Similarity:	202/512 - (39%)	Gaps:	126/512 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VVGVLLLVAFATLLLWDFLWRRRGNGILPGPRP-------LPFLGNLLMYRGLDPEQIMDFVKKN 61
            :..|..|:|....:|:.:...|:.:|| ||..|       ||.:.|        ...:.:|:...
  Rat     6 IFAVTFLLALVGAVLYLYPASRQASGI-PGLTPTEEKDGNLPDIVN--------SGSLHEFLVNL 61

  Fly    62 QRKYGRLYRVWILHQLAVFSTDPRDIEFVLSSQQHITKNN--------LYKLLNCWLGDGLLMST 118
            ..:||.:...|...:|.| |....|     :.:||...|.        |..||....|.|    :
  Rat    62 HGRYGPVVSFWFGRRLVV-SLGTAD-----ALKQHFNPNKTLDPFETMLKSLLGYRSGAG----S 116

  Fly   119 GRKWHGRRKIITPTFHFKILEQFVEIFDQQSAVMVEQLQSRADGMTPINIFPVICLTALDIIAET 183
            |.:.|.||::                   ....:...|||.         ||::..     ::|.
  Rat   117 GSEDHVRRRL-------------------YGDAVTAALQSN---------FPLLLK-----LSEE 148

  Fly   184 AMGTKINAQKNPNLPYVQ-----AVNDVTNIL----------IKRF--IH--AWQRVDWIF---R 226
            .:...::..:..::|..|     |:..||.::          :.||  ||  .|..:...|   .
  Rat   149 LLDKWLSYPETQHIPLSQHMLGFALKFVTRMVLGDTFEGEQEVIRFQKIHGTVWSEIGKGFLDGS 213

  Fly   227 LTQPTEAKRQ-DKAIKVMHDFTENIIRERRETLVNNSKETTPEEEVNFLGQKRRMALLDVLLQST 290
            |.:.|..|.| .:|:..:....:.||:||:.                  |...:...:|.|:|..
  Rat   214 LDKNTTRKNQYQEALMQLEAILKKIIKERKG------------------GDFSQHTFIDSLVQRN 260

  Fly   291 IDGAPLSDEDIREEVDTFMFEGHDTTTSAISFCLYEISRHPEVQQRLQQEIRDVLGEDRKSPVTL 355
                 |:::.|.|:...|...|...|....::.::.::...|||::|.:|:..|||   |.|:|.
  Rat   261 -----LNEQQILEDSVVFSLAGCIVTARLCTWAIHFLTTAEEVQKKLHKEVDHVLG---KGPITS 317

  Fly   356 RDLGELKFMENVIKESLRLHPPVPMIGRWFAEDVEIRGK----HIPAGTNFTMGIFVLLRDPEYF 416
            ..:.:|::.:.|:.|::|.....|:..:  .:|:|  ||    .||..|.....:.|:|:|...:
  Rat   318 EKIEQLRYCQQVLCETVRTAKLTPVSAQ--LQDIE--GKVGPFIIPKETLVLYALGVVLQDASTW 378

  Fly   417 ESPDEFRPERFDADVPQIHPYAYIPFSAGPRNCIGQKFAMLEMKSTVSKLLRHFELL 473
            .||.:|.|:|| ||.|.:..::.:.|| |...|...:||.:.....||.||:...||
  Rat   379 PSPHKFDPDRF-ADEPVMKVFSSLGFS-GTWECPELRFAYVVTTVLVSVLLKKLHLL 433

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d2	NP_001284806.1	p450	32..495	CDD:278495	109/484 (23%)
Cyp20a1	NP_955433.1	p450	43..415	CDD:299894	98/454 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000