DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d2 and Cyp4f5

DIOPT Version :9

Sequence 1:	NP_001284806.1	Gene:	Cyp4d2 / 31192	FlyBaseID:	FBgn0011576	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_775147.1	Gene:	Cyp4f5 / 286905	RGDID:	708364	Length:	526	Species:	Rattus norvegicus

Alignment Length:	514	Identity:	180/514 - (35%)
Similarity:	284/514 - (55%)	Gaps:	31/514 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLGVVGVLLLVAFATLLLWDFLWRRRGNGI--LP-GPRPLPFLGNLLMYRGLDPEQIMDFVKKNQ 62
            :||....:|    |.:|.|.:.:....:.:  .| .|:...|||:|...:  ..|:.|..|.:..
  Rat    23 LLGAASWIL----ARILAWTYSFCENCSRLRCFPQSPKRNWFLGHLGTIQ--SNEEGMRLVTEMG 81

  Fly    63 RKYGRLYRVWILHQLAVFS-TDPRDIEFVLSSQQHITKNN--LYKLLNCWLGDGLLMSTGRKWHG 124
            :.:..::..|:...:.|.. .||..:..:|.:...:...:  ..:.|..||||||.:|:|.||..
  Rat    82 QTFRDIHLCWLGPVIPVLRLVDPAFVAPLLQAPALVAPKDTTFLRFLKPWLGDGLFLSSGDKWSR 146

  Fly   125 RRKIITPTFHFKILEQFVEIFDQQSAVMVEQLQSRA-DGMTPINIFPVICLTALDIIAETAMGTK 188
            .|:::||.|||.||:.:|:||:|...:|..:.:... :|...:.:|..|.|..||.:.:...|..
  Rat   147 HRRLLTPAFHFDILKPYVKIFNQSVNIMHAKWKHLCLEGSARLEMFENISLMTLDSLQKCLFGFD 211

  Fly   189 INAQKNPNLPYVQAVNDVTNILIKRFIHAWQRVDWIFRLTQPTEAKRQDKAIKVMHDFTENIIRE 253
            .|.|::|: .|:.|:.::::::|||....:..:|:::..|  .:.:|..||..::|:||:.:|||
  Rat   212 SNCQESPS-EYISAILELSSLIIKRSQQLFLYLDFLYYRT--ADGRRFRKACDLVHNFTDAVIRE 273

  Fly   254 RRETLVNNSKETTPEEEVNFLGQK-----RRMALLDVLLQSTID-GAPLSDEDIREEVDTFMFEG 312
            ||..|   |.:.|.|    ||..|     :.:..:||||.:..: |..|||||||.|.|||||.|
  Rat   274 RRRLL---SSQGTDE----FLESKTKSKSKTLDFIDVLLLAKDEHGKELSDEDIRAEADTFMFGG 331

  Fly   313 HDTTTSAISFCLYEISRHPEVQQRLQQEIRDVLGEDRKSPVTLRDLGELKFMENVIKESLRLHPP 377
            ||||.||:|:.||.::||||.|:|.:||:.::|.:.....:...||.:|.|:...||||||||||
  Rat   332 HDTTASALSWILYNLARHPEYQERCRQEVWELLRDREPEEIEWDDLAQLPFLTMCIKESLRLHPP 396

  Fly   378 VPMIGRWFAEDVEI-RGKHIPAGTNFTMGIFVLLRDPEYFESPDEFRPERFDADVPQIH-PYAYI 440
            ...:.|...:|:.: .|:.||.|....:.||.:..:|..:..|:.|.|.|||::..|.. |.::|
  Rat   397 AIDLLRRCTQDIVLPDGRVIPKGNICVISIFGIHHNPSVWPDPEVFDPFRFDSENRQKRSPLSFI 461

  Fly   441 PFSAGPRNCIGQKFAMLEMKSTVSKLLRHFELLPLGPEPRHSMNIVLRSANGVHLGLKP 499
            ||||||||||||.|||.|||..|:..|..|.:||...|||....|:||:..|:.|.::|
  Rat   462 PFSAGPRNCIGQTFAMNEMKVVVALTLLRFRVLPDDKEPRRKPEIILRAEGGLWLRMEP 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d2	NP_001284806.1	p450	32..495	CDD:278495	172/475 (36%)
Cyp4f5	NP_775147.1	p450	52..516	CDD:278495	172/475 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348538
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.640