DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4d2 and Cyp4f4

DIOPT Version :9

Sequence 1:	NP_001284806.1	Gene:	Cyp4d2 / 31192	FlyBaseID:	FBgn0011576	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_775146.1	Gene:	Cyp4f4 / 286904	RGDID:	708363	Length:	522	Species:	Rattus norvegicus

Alignment Length:	512	Identity:	187/512 - (36%)
Similarity:	283/512 - (55%)	Gaps:	33/512 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VLLLVAFATLLL----WDFLWRRRGNGILPGPRPLP----FLGNLLMYRGLDP-EQIMDFVKKNQ 62
            :|||:..:.||:    ..:::.|....:...|:| |    |||:|.|   :.| ||.:..|.|..
  Rat    21 LLLLIGASWLLVRVLTQTYIFYRTYQHLCDFPQP-PKWNWFLGHLGM---ITPTEQGLKQVTKLV 81

  Fly    63 RKYGRLYRVWILHQLAVFS-TDPRDIEFVLSSQQHITKNNL--YKLLNCWLGDGLLMSTGRKWHG 124
            ..|.:.:..|:...|.:.: ..|..|..|||:...:....:  |..|..|||||||:|.|.||..
  Rat    82 ATYPQGFMTWLGPILPIITLCHPDVIRSVLSASASVALKEVIFYSFLKPWLGDGLLLSDGDKWSC 146

  Fly   125 RRKIITPTFHFKILEQFVEIFDQQSAVMVEQLQSRAD-GMTPINIFPVICLTALDIIAETAMGTK 188
            .|:::||.|||.||:.:|:||:..:.:|..:.|..|. |...:::|..|.|..||.:.:......
  Rat   147 HRRMLTPAFHFNILKPYVKIFNDSTNIMHAKWQDLASGGSARLDMFKNISLMTLDSLQKCVFSFD 211

  Fly   189 INAQKNPNLPYVQAVNDVTNILIKRFIHAWQRVDWIFRLTQPTEAKRQDKAIKVMHDFTENIIRE 253
            .|.|:.|: .|:.|:.:::.::.||:.......|.:::||.  ..:|..||.|::|:||:.:|:.
  Rat   212 SNCQEKPS-EYISAILELSALVAKRYQQLLLHTDSLYQLTH--NGRRFHKACKLVHNFTDAVIQG 273

  Fly   254 RRETLVNNSKETTPEEEVNFLGQKRRMALLD----VLLQSTIDGAPLSDEDIREEVDTFMFEGHD 314
            ||..|.:       :.|.:.|..|.|...||    :||....||..|||||||.|.|||||||||
  Rat   274 RRRALPS-------QHEDDILKAKARSKTLDFIDVLLLTKDEDGKELSDEDIRAEADTFMFEGHD 331

  Fly   315 TTTSAISFCLYEISRHPEVQQRLQQEIRDVLGEDRKSPVTLRDLGELKFMENVIKESLRLHPPVP 379
            ||.|.:|:.||.::||||.|:|.:||:|::|.:...:.:...||.:|.|:...|||||||||||.
  Rat   332 TTASGLSWILYNLARHPEYQERCRQEVRELLRDRESTEIEWDDLAQLPFLTMCIKESLRLHPPVT 396

  Fly   380 MIGRWFAEDVEI-RGKHIPAGTNFTMGIFVLLRDPEYFESPDEFRPERFDAD-VPQIHPYAYIPF 442
            :|.|...:|:.: .|:.||.|....:.||....:|..:..|:.:.|.|||.: :....|.|:|||
  Rat   397 VISRRCTQDIVLPDGRVIPKGVICIINIFATHHNPTVWPDPEVYDPFRFDPENIKDRSPLAFIPF 461

  Fly   443 SAGPRNCIGQKFAMLEMKSTVSKLLRHFELLPLGPEPRHSMNIVLRSANGVHLGLKP 499
            ||||||||||.|||.|||..::..|..|.:||...|||....::||:..|:.|.::|
  Rat   462 SAGPRNCIGQTFAMNEMKVALALTLLRFRVLPDDKEPRRKPELILRAEGGLWLRVEP 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d2	NP_001284806.1	p450	32..495	CDD:278495	179/477 (38%)
Cyp4f4	NP_775146.1	CYP4F	74..515	CDD:410772	168/450 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348612
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.650