DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4d2 and CYP4V2

DIOPT Version :9

Sequence 1:	NP_001284806.1	Gene:	Cyp4d2 / 31192	FlyBaseID:	FBgn0011576	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_997235.3	Gene:	CYP4V2 / 285440	HGNCID:	23198	Length:	525	Species:	Homo sapiens

Alignment Length:	538	Identity:	210/538 - (39%)
Similarity:	322/538 - (59%)	Gaps:	59/538 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VVGVLLLVAFATLLLW---------------DFLWR-----RRGNGILPGP---RPLPFLGNLLM 45
            :.|:.|.:.:..||||               ..|.|     |:...:.|.|   |..|.:|:.|:
Human     1 MAGLWLGLVWQKLLLWGAASALSLAGASLVLSLLQRVASYARKWQQMRPIPTVARAYPLVGHALL 65

  Fly    46 YRGLDP------EQIMDFVKKNQRKYGRLYRVWI--LHQLAVFSTDPRDIEFVLSSQQHITKNNL 102
               :.|      :||:::.:  :.::..|.::|:  :..:|:::.:  ::|.:|:|.:.|.|:::
Human    66 ---MKPDGREFFQQIIEYTE--EYRHMPLLKLWVGPVPMVALYNAE--NVEVILTSSKQIDKSSM 123

  Fly   103 YKLLNCWLGDGLLMSTGRKWHGRRKIITPTFHFKILEQFVEIFDQQSAVMVEQLQSRADGMTPIN 167
            ||.|..|||.|||.|||.||..|||::||||||.|||.|::|.::|:.::|::|:...: ....|
Human   124 YKFLEPWLGLGLLTSTGNKWRSRRKMLTPTFHFTILEDFLDIMNEQANILVKKLEKHIN-QEAFN 187

  Fly   168 IFPVICLTALDIIAETAMGTKINAQKNPNLPYVQAVNDVTNILIKRFIHAWQRVD-WIFRLTQPT 231
            .|..|.|.|||||.|||||..|.||.|.:..||:||..::.::.:|....|..:| |.....:..
Human   188 CFFYITLCALDIICETAMGKNIGAQSNDDSEYVRAVYRMSEMIFRRIKMPWLWLDLWYLMFKEGW 252

  Fly   232 EAKRQDKAIKVMHDFTENIIRERRETLVNNSKETTPEEEVNFLGQKRRMALLDVLLQSTID-GAP 295
            |.|   |:::::|.||.::|.||...: |.:::...:...:...:.:|.|.||:||..|.| |..
Human   253 EHK---KSLQILHTFTNSVIAERANEM-NANEDCRGDGRGSAPSKNKRRAFLDLLLSVTDDEGNR 313

  Fly   296 LSDEDIREEVDTFMFEGHDTTTSAISFCLYEISRHPEVQQRLQQEIRDVLGE-DRKSPVTLRDLG 359
            ||.||||||||||||||||||.:||::.||.:..:||||:::..|:.||.|: ||  |.|:.||.
Human   314 LSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHELDDVFGKSDR--PATVEDLK 376

  Fly   360 ELKFMENVIKESLRLHPPVPMIGRWFAEDVEIRGKHIPAGTNFTMGIFVLLRDPEYFESPDEFRP 424
            :|:::|.||||:|||.|.||:..|..:||.|:.|..:..||...:..:.|.|||.||.:|:||:|
Human   377 KLRYLECVIKETLRLFPSVPLFARSVSEDCEVAGYRVLKGTEAVIIPYALHRDPRYFPNPEEFQP 441

  Fly   425 ERFDADVPQ-IHPYAYIPFSAGPRNCIGQKFAMLEMKSTVSKLLRHF------ELLPLGPEPRHS 482
            |||..:..| .|||||:|||||||||||||||::|.|:.:|.:||||      :...||.|.:
Human   442 ERFFPENAQGRHPYAYVPFSAGPRNCIGQKFAVMEEKTILSCILRHFWIESNQKREELGLEGQ-- 504

  Fly   483 MNIVLRSANGVHLGLKPR 500
              ::||.:||:.:.||.|
Human   505 --LILRPSNGIWIKLKRR 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d2	NP_001284806.1	p450	32..495	CDD:278495	198/483 (41%)
CYP4V2	NP_997235.3	p450	55..517	CDD:278495	196/479 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154647
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	LDO	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.750