Protein Alignment Cyp4d2 and CYP4A22

DIOPT Version :10

• Sequence 1: NP_525043.1
• Gene: Cyp4d2 / 31192
• FlyBaseID: FBgn0011576
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_001010969.2
• Gene: CYP4A22 / 284541
• HGNCID: 20575
• Length: 519
• Species: Homo sapiens
• Alignment Length: 513
• Identity: 161/513 - (31%)
• Similarity: 271/513 - (52%)
• Gaps: 36/513 - (7%)

  Fly     3 GVVGVLLLVAFATLLLWDFL-----------WRRRGNGILPGPRPLPFLGNLLMYRGLDPEQIMD 56
            ||.|:|.:.:...|||  .|           |..:.....|.|......|::..::   .:|.:.
Human    14 GVSGILQVTSLLILLL--LLIKAAQLYLHRQWLLKALQQFPCPPSHWLFGHIQEFQ---HDQELQ 73

  Fly    57 FVKKNQRKYGRLYRVWIL-HQLAVFSTDPRDIEFVLSSQQHITKNNLYKLLNCWLGDGLLMSTGR 120
            .:::..:.:......||. .::.|...|| |...|:..:.....:..||.|...:|.|||:..|:
Human    74 RIQERVKTFPSACPYWIWGGKVRVQLYDP-DYMKVILGRSDPKSHGSYKFLAPRIGYGLLLLNGQ 137

  Fly   121 KWHGRRKIITPTFHFKILEQFVEIFDQQSAVMVEQLQSRADGMTPINIFPVICLTALDIIAETAM 185
            .|...|:::||.||..||:.:|.:......||:::.:......:|:.:|..:.|..||.|.::|.
Human   138 TWFQHRRMLTPAFHNDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKSAF 202

  Fly   186 GTKINAQKNPN-LPYVQAVNDVTNILIKRFIHAWQRVDWIFRLTQPTEAKRQDKAIKVMHDFTEN 249
            ..:.:.|.:.| ..|:||::|:.:::.....:|:...|.|:.||  :..:...:|.::.|..|:.
Human   203 SHQGSIQVDRNSQSYIQAISDLNSLVFCCMRNAFHENDTIYSLT--SAGRWTHRACQLAHQHTDQ 265

  Fly   250 IIRERRETLVNNSKETTPEEEVNFLGQKRRMALLDVLLQSTID-GAPLSDEDIREEVDTFMFEGH 313
            :|:.|:..|       ..|.|:..:.:||.:..||:||.:.:: |:.|||:|:|.||||||||||
Human   266 VIQLRKAQL-------QKEGELEKIKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGH 323

  Fly   314 DTTTSAISFCLYEISRHPEVQQRLQQEIRDVLGEDRKSPVTLRDLGELKFMENVIKESLRLHPPV 378
            |||.|.||:.||.::.||:.|:|.::||..:||:.  :.:|...|.::.:....|||:|||:|||
Human   324 DTTASGISWILYALATHPKHQERCREEIHGLLGDG--ASITWNHLDQMPYTTMCIKEALRLYPPV 386

  Fly   379 PMIGRWFAEDVEI-RGKHIPAGTNFTMGIFVLLRDPEYFESPDEFRPERFDADVPQIHPYAYIPF 442
            |.|||..:..|.. .|:.:|.|....:.|:.|..:|:.:.:.:.|.|.||.....| |.:|::||
Human   387 PGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNLEVFDPSRFAPGSAQ-HSHAFLPF 450

  Fly   443 SAGPRNCIGQKFAMLEMKSTVSKLLRHFELLPLGPE--PRHSMNIVLRSANGVHLGLK 498
            |.|.|||||::|||.::|...:..|..||||| .|.  |.....:||:|.||:||.|:
Human   451 SGGSRNCIGKQFAMNQLKVARALTLLRFELLP-DPTRIPIPMARLVLKSKNGIHLRLR 507

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d2	NP_525043.1	CYP4	66..495	CDD:410721	145/434 (33%)
CYP4A22	NP_001010969.2	CYP4B-like	72..505	CDD:410771	146/446 (33%)