DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4d2 and Cyp4v3

DIOPT Version :9

Sequence 1:	NP_001284806.1	Gene:	Cyp4d2 / 31192	FlyBaseID:	FBgn0011576	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001129072.1	Gene:	Cyp4v3 / 266761	RGDID:	708530	Length:	525	Species:	Rattus norvegicus

Alignment Length:	542	Identity:	214/542 - (39%)
Similarity:	316/542 - (58%)	Gaps:	70/542 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LGVVGVLLL---------VAFATLLLWDFL-----WRRRGNGILPGP---RPLPFLGNLLMYRGL 49
            ||:.|..||         ||.||:|| :.|     :.|:...:.|.|   |..|.:|:.|..:..
  Rat     6 LGLSGQKLLLWGAASAVSVAGATVLL-NILQMLVSYARKWQQMRPIPSVARAYPLVGHALFMKPN 69

  Fly    50 DPE---QIMDFVKKNQRKYGRLYRVWI--LHQLAVFSTDPRDIEFVLSSQQHITKNNLYKLLNCW 109
            :.|   ||:.:.:  :.::..:.::||  :..:|::..:  ::|.:|:|.:.|.|:.:||.|..|
  Rat    70 NTEFFQQIIQYTE--EFRHLPIIKLWIGPVPLVALYKAE--NVEVILTSSKQIDKSFMYKFLQPW 130

  Fly   110 LGDGLLMSTGRKWHGRRKIITPTFHFKILEQFVEIFDQQSAVMVEQLQSRADGMTPINIFPVICL 174
            ||.|||.|||.||..|||::||:|||.|||.|:::.::|:.::|.:|:...: ....|.|..|.|
  Rat   131 LGLGLLTSTGSKWRARRKMLTPSFHFTILEDFLDVMNEQANILVNKLEKHVN-QEAFNCFFPITL 194

  Fly   175 TALDIIAETAMGTKINAQKNPNLPYVQAVNDVTNILIKRFIHAWQRVD-W--IFRLTQPTEAKRQ 236
            .|||||.|||||..|.||.|.:..||:.|..:::::.:|....|...| |  :|:     |.:..
  Rat   195 CALDIICETAMGKNIGAQSNGDSEYVRTVYRMSDMIYRRMKMPWFWFDLWYLMFK-----EGRDH 254

  Fly   237 DKAIKVMHDFTENIIRERRETLVNNSKETTPEEEVNFLG--------QKRRMALLDVLLQST-ID 292
            .|.:|.:|.||.|:|.||    ||..|     .|.:.:|        :.:|.|.||:||..| .:
  Rat   255 KKGLKSLHTFTNNVIAER----VNARK-----AEQDCIGAGRGPLPSKTKRKAFLDLLLSVTDEE 310

  Fly   293 GAPLSDEDIREEVDTFMFEGHDTTTSAISFCLYEISRHPEVQQRLQQEIRDVLGEDRKSPVTLRD 357
            |..||.||||||||||||||||||.:||::.||.:..:||||:::.:|:.||.|...: ||||.|
  Rat   311 GNKLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQRKVDKELDDVFGRSHR-PVTLED 374

  Fly   358 LGELKFMENVIKESLRLHPPVPMIGRWFAEDVEIRGKHIPAGTNFTMGIFVLLRDPEYFESPDEF 422
            |.:||:::.||||:||:.|.||:..|..:||.|:.|..|..||...:..:.|.|||.||..|:||
  Rat   375 LKKLKYLDCVIKETLRVFPSVPLFARSLSEDCEVAGYKISKGTEAVIIPYALHRDPRYFPDPEEF 439

  Fly   423 RPERFDADVPQ-IHPYAYIPFSAGPRNCIGQKFAMLEMKSTVSKLLRHF--------ELLPLGPE 478
            :||||..:..| .|||||:|||||||||||||||::|.|:.::.:||.|        |.|.|..:
  Rat   440 QPERFFPENSQGRHPYAYVPFSAGPRNCIGQKFAVMEEKTILACILREFWIESNQKREELGLAGD 504

  Fly   479 PRHSMNIVLRSANGVHLGLKPR 500
                  ::||..||:.:.||.|
  Rat   505 ------LILRPNNGIWIKLKRR 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d2	NP_001284806.1	p450	32..495	CDD:278495	198/491 (40%)
Cyp4v3	NP_001129072.1	CYP4V	76..515	CDD:410773	191/464 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348391
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	LDO	PTHR24291
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.750