DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d2 and Cyp4f6

DIOPT Version :9

Sequence 1:	NP_001284806.1	Gene:	Cyp4d2 / 31192	FlyBaseID:	FBgn0011576	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	XP_006241111.1	Gene:	Cyp4f6 / 266689	RGDID:	708365	Length:	538	Species:	Rattus norvegicus

Alignment Length:	481	Identity:	176/481 - (36%)
Similarity:	276/481 - (57%)	Gaps:	32/481 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 PRPLPFLGNLLMYRGLDPEQIMDFVKKNQRKYGRLYRVWI---------LHQLAVFSTDPRDIEF 89
            |:|..|.|:|.:.:  :.|:.|.|:....|.:..::..|:         :|        |..|..
  Rat    56 PKPSWFWGHLTLMK--NNEEGMQFIAHLGRNFRDIHLSWVGPVYPILRLVH--------PNVIAP 110

  Fly    90 VLSSQQHIT--KNNLYKLLNCWLGDGLLMSTGRKWHGRRKIITPTFHFKILEQFVEIFDQQSAVM 152
            :|.:...:.  :..||..|..|||||||||.|.||:..|:::||.|||.||:.:|:||::....|
  Rat   111 LLQASAAVAPKEMTLYGFLKPWLGDGLLMSAGEKWNHHRRLLTPAFHFDILKSYVKIFNKSVNTM 175

  Fly   153 VEQLQS-RADGMTPINIFPVICLTALDIIAETAMGTKINAQKNPNLPYVQAVNDVTNILIKRFIH 216
            ..:.|. .|.|...:::|..|.|..||.:.:.......|.|:: |..|:.|:.:::::::||...
  Rat   176 HAKWQRLTAKGSARLDMFEHISLMTLDSLQKCIFSFDSNCQES-NSEYIAAILELSSLIVKRQRQ 239

  Fly   217 AWQRVDWIFRLTQPTEAKRQDKAIKVMHDFTENIIRERRETLVNNSKETTPEEEVNFLGQKRRMA 281
            .:..:|:::.||  .:.:|..||..|:|:||:.:|||||.||  |::..  :|.:....:.:.:.
  Rat   240 PFLYLDFLYYLT--ADGRRFRKACDVVHNFTDAVIRERRSTL--NTQGV--DEFLKARAKTKTLD 298

  Fly   282 LLDVLLQSTID-GAPLSDEDIREEVDTFMFEGHDTTTSAISFCLYEISRHPEVQQRLQQEIRDVL 345
            .:||||.:..: |..|||.|||.|.|||||.|||||.||:|:.||.::||||.|:|.:||:|::|
  Rat   299 FIDVLLLAKDEHGKGLSDVDIRAEADTFMFGGHDTTASALSWILYNLARHPEYQERCRQEVRELL 363

  Fly   346 GEDRKSPVTLRDLGELKFMENVIKESLRLHPPVPMIGRWFAEDVEI-RGKHIPAGTNFTMGIFVL 409
            .:.....:...||.:|.|:...|||||||||||.:|.|..::|:.: .|:.||.|....:.||.:
  Rat   364 RDREPEEIEWDDLAQLPFLTMCIKESLRLHPPVLLISRCCSQDIVLPDGRVIPKGNICVISIFGV 428

  Fly   410 LRDPEYFESPDEFRPERFDADVPQIH-PYAYIPFSAGPRNCIGQKFAMLEMKSTVSKLLRHFELL 473
            ..:|..:..|:.:.|.|||.:.||.. |.|:|||||||||||||.|||.|:|..::..|..|.:|
  Rat   429 HHNPSVWPDPEVYNPFRFDPENPQKRSPLAFIPFSAGPRNCIGQTFAMSEIKVALALTLLRFCVL 493

  Fly   474 PLGPEPRHSMNIVLRSANGVHLGLKP 499
            |...|||....::||:..|:.|.::|
  Rat   494 PDDKEPRRKPELILRAEGGLWLRVEP 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d2	NP_001284806.1	p450	32..495	CDD:278495	174/475 (37%)
Cyp4f6	XP_006241111.1	p450	53..515	CDD:278495	174/475 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348541
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.650