Protein Alignment Cyp4d2 and Cyp4a8

DIOPT Version :10

• Sequence 1: NP_525043.1
• Gene: Cyp4d2 / 31192
• FlyBaseID: FBgn0011576
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_113793.2
• Gene: Cyp4a8 / 266674
• RGDID: 628846
• Length: 508
• Species: Rattus norvegicus
• Alignment Length: 517
• Identity: 163/517 - (31%)
• Similarity: 271/517 - (52%)
• Gaps: 48/517 - (9%)

  Fly     4 VVGVLLLVAFATLLLWDF---------LWRRRGNGILPGPRPLPFLGNLLMYRGLDPEQIMDFVK 59
            ::|.|.:....|:||..|         .|..|.....|.|....|.|:.:. :..:.:.|:..||
  Rat    15 ILGFLQIATVLTVLLLLFKTAQFYLHRRWLLRATQQFPSPPSHWFFGHKIP-KDQEFQDILTRVK 78

  Fly    60 K-----NQRKYGRLYRVWILHQLAVFSTDPRDIEFVLSSQQHITKNNLYKLLNCWLGDGLLMSTG 119
            .     .|..:|...|:.:.        ||..::.:| .:.....::.|:.|..|:|.|||:..|
  Rat    79 NFPSACPQWLWGSNVRIQVY--------DPDYMKLIL-GRSDPKSHHSYRFLAPWIGYGLLLLNG 134

  Fly   120 RKWHGRRKIITPTFHFKILEQFVEIFDQQSAVMVEQLQSRADGMTPINIFPVICLTALDIIAETA 184
            :.|...|:::||.||:..|:.:|.|......:|:::.:......:.:.||..|.|..||.|.:.|
  Rat   135 QTWFQHRRMLTPAFHYDTLKPYVGIMADSVRIMLDKWEQIVGQDSTLEIFQHITLMTLDTIMKCA 199

  Fly   185 MGTKINAQKNPNL-PYVQAVNDVTNILIKRFIHAWQRVDWIFRLTQPTEAKRQDKAIKVMHDFTE 248
            ...:.:.|.:... .|::||.|:.|:...|..:.:.:.|.|:.|:  :..::...|.::.|:.|:
  Rat   200 FSQEGSVQLDRKYKSYIKAVEDLNNLSFFRIRNIFHQNDIIYSLS--SNGRKARSAWQLAHEHTD 262

  Fly   249 NIIRERRETLVNNSKETTPEEEVNFLGQKRRMALLDVLLQSTID-GAPLSDEDIREEVDTFMFEG 312
            .:|:.|:..|.:       |||:..:.||||:..||:||.:.|: |:.|||:|:|.|||||||||
  Rat   263 QVIKSRKAQLQD-------EEELQKVKQKRRLDFLDILLFARIENGSSLSDKDLRAEVDTFMFEG 320

  Fly   313 HDTTTSAISFCLYEISRHPEVQQRLQQEIRDVLGEDRKSPVTLRDLGELKFMENVIKESLRLHPP 377
            ||||.|.||:..|.::.:||.||..::||:.:||:.  :.:|..||.::.:....|||:||::||
  Rat   321 HDTTASGISWIFYALATNPEHQQGCRKEIQSLLGDG--ASITWDDLDKMPYTTMCIKEALRIYPP 383

  Fly   378 VPMIGRWFAEDVEI-RGKHIPAGTNFTMGIFVLLRDPEYFESPDEFRPERFDADVPQIHPYAYIP 441
            |..:.|..:..|.. .|:.:|.|....:..:.|..:|..:.:|:.|.|.|| |.....|.::::|
  Rat   384 VTAVSRMLSTPVTFPDGRSLPKGITVMLSFYGLHHNPTVWPNPEVFDPYRF-APESSRHSHSFLP 447

  Fly   442 FSAGPRNCIGQKFAMLEMKSTVSKLLRHFELLPLG-----PEPRHSMNIVLRSANGVHLGLK 498
            ||.|.|||||::|||.|:|..|:..|..|||||..     |.||    :||:|.||::|.||
  Rat   448 FSGGARNCIGKQFAMNELKVAVALTLLRFELLPDPTRIPIPIPR----LVLKSKNGIYLRLK 505

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d2	NP_525043.1	CYP4	66..495	CDD:410721	144/436 (33%)
Cyp4a8	NP_113793.2	CYP4B-like	70..503	CDD:410771	148/457 (32%)