Protein Alignment Cyp4d2 and Cyp3a23-3a1

DIOPT Version :10

• Sequence 1: NP_525043.1
• Gene: Cyp4d2 / 31192
• FlyBaseID: FBgn0011576
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_037237.2
• Gene: Cyp3a23-3a1 / 25642
• RGDID: 628626
• Length: 502
• Species: Rattus norvegicus
• Alignment Length: 506
• Identity: 142/506 - (28%)
• Similarity: 249/506 - (49%)
• Gaps: 92/506 - (18%)

  Fly     9 LLVAFATLLLWDF------LWRRRGNGILPGPRPLPFLGNLL-MYRGLDPEQIMDFVKKNQRKYG 66
            :|:|...:||:.|      |::::|   :|||:||||.|.:| .|.||     ..|..:..:|||
  Rat    13 VLLAVVLVLLYGFGTRTHGLFKKQG---IPGPKPLPFFGTVLNYYMGL-----WKFDVECHKKYG 69

  Fly    67 RLYRVWILH--QLAVFSTDPRDIEFVLSSQQHITKNNLYKLLNCW--------------LGDGLL 115
               ::|.|.  |:.:|:.  .|.|.:        ||.|.|  .|:              :|..:.
  Rat    70 ---KIWGLFDGQMPLFAI--TDTEMI--------KNVLVK--ECFSVFTNRRDFGPVGIMGKAIS 119

  Fly   116 MSTGRKWHGRRKIITPTFHFKILEQFVEIFDQQSAVMVEQLQSRADGMTPINIFPVICLTALDII 180
            :|...:|...|.:::|||....|::...:.:|...::|:.|  |.:...|:.:..|....::|:|
  Rat   120 VSKDEEWKRYRALLSPTFTSGRLKEMFPVIEQYGDILVKYL--RQEKGKPVPVKEVFGAYSMDVI 182

  Fly   181 AETAMGTKINAQKNPNLPYVQAVNDVTNILIKRFIHAWQRVDW---------IFRLTQPT-EAKR 235
            ..|:.|..:::..||..|:|:..        |:.:    |:|:         :|....|. |...
  Rat   183 TSTSFGVNVDSLNNPKDPFVEKA--------KKLL----RIDFFDPLFLSVVLFPFLTPVYEMLN 235

  Fly   236 QDKAIKVMHDFTENIIRERRETLVNNSKETTPEEEVNFLGQKRRMALLDVLLQSTIDG------A 294
            .....|...:|.:..:...:||.:::.             ||.|:..|.:::.:..|.      .
  Rat   236 ICMFPKDSIEFFKKFVYRMKETRLDSV-------------QKHRVDFLQLMMNAHNDSKDKESHT 287

  Fly   295 PLSDEDIREEVDTFMFEGHDTTTSAISFCLYEISRHPEVQQRLQQEIRDVLGEDRKSPVTLRDLG 359
            .|||.:|..:...|:|.|::.|:|.:||.|:.::.||:.|::||:||...|  ..|:|.|...:.
  Rat   288 ALSDMEITAQSIIFIFAGYEPTSSTLSFVLHSLATHPDTQKKLQEEIDRAL--PNKAPPTYDTVM 350

  Fly   360 ELKFMENVIKESLRLHPPVPMIGRWFAEDVEIRGKHIPAGTNFTMGIFVLLRDPEYFESPDEFRP 424
            |:::::.|:.|:|||:|....:.|...:||||.|..:|.|:...:..:.|.|||:::..|:||||
  Rat   351 EMEYLDMVLNETLRLYPIGNRLERVCKKDVEINGVFMPKGSVVMIPSYALHRDPQHWPEPEEFRP 415

  Fly   425 ERFDAD-VPQIHPYAYIPFSAGPRNCIGQKFAMLEMKSTVSKLLRHFELLP 474
            |||..: ...|.||.|:||..|||||||.:||::.||..::|:|::|...|
  Rat   416 ERFSKENKGSIDPYVYLPFGNGPRNCIGMRFALMNMKLALTKVLQNFSFQP 466

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d2	NP_525043.1	CYP4	66..495	CDD:410721	120/442 (27%)
Cyp3a23-3a1	NP_037237.2	CYP3A	67..491	CDD:410743	122/444 (27%)