DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d2 and Cyp4x1

DIOPT Version :9

Sequence 1:	NP_001284806.1	Gene:	Cyp4d2 / 31192	FlyBaseID:	FBgn0011576	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_663708.1	Gene:	Cyp4x1 / 246767	RGDID:	628719	Length:	507	Species:	Rattus norvegicus

Alignment Length:	510	Identity:	171/510 - (33%)
Similarity:	266/510 - (52%)	Gaps:	36/510 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LGVVGVLLLVAFATLLLWDFLWRRRGNGILPGPRPLP------FLGNLLMYRGLDPEQIMDFVKK 60
            |.:|..|.||....:.|  :|.|:|   :|...||.|      .||:....:..:.|::.:.||
  Rat    16 LALVFCLALVLMQAVKL--YLRRQR---LLRDLRPFPGPTAHWLLGHQKFLQEDNMEKLDEIVK- 74

  Fly    61 NQRKYGRLYRVWI-LHQLAVFSTDPRDIEFVLSSQQHITKNNLYKLLNCWLGDGLLMSTGRKWHG 124
               :|...:..|: ..|...:..||...:..||.....|: .|::|:..:||.|||...|.:|..
  Rat    75 ---EYPCAFPCWVGPFQAFFYIYDPDYAKIFLSRTDPKTQ-YLHQLMTPFLGRGLLNLDGPRWFQ 135

  Fly   125 RRKIITPTFHFKILEQFVEIFDQQSAVMVEQLQSR-ADGMTPINIFPVICLTALDIIAETAMGTK 188
            .|.::||.||..||:..|::......:|:::.:.. ....|.|.:|..|.|..||||.:.|.|.:
  Rat   136 HRCLLTPAFHQDILKPCVDMMAHSVNMMLDKWEKTWTTQETTIEVFEHINLMTLDIIMKCAFGQE 200

  Fly   189 INAQKNPNL-PYVQAVNDVTNILIKRFIHAWQRVDWIFRLTQPTEAKRQDKAIKVMHDFTENIIR 252
            .|.|.|... .||:|..::..|:..|..:.|...|.||:|: |.....|:.. ||:|..||.||:
  Rat   201 TNCQINGTYESYVKATFELGEIISSRLYNFWHHHDIIFKLS-PKGHCFQELG-KVIHQCTEKIIQ 263

  Fly   253 ERRETLVNNSKETTPEEEVNFLGQKRRMALLDVLLQSTI-DGAPLSDEDIREEVDTFMFEGHDTT 316
            :|::||.:...:...:...||         ||::|.:.. |....||.|:|.||:|||:.|||.:
  Rat   264 DRKKTLKDQVNQDDTQTSQNF---------LDIVLSAQAGDEKAFSDADLRSEVNTFMWAGHDAS 319

  Fly   317 TSAISFCLYEISRHPEVQQRLQQEIRDVLGEDRKSPVTLRDLGELKFMENVIKESLRLHPPVPMI 381
            .::||:.||.::.:||.|.|.:.|||.:||:.  |.:|...|.|:.:....|||:|||.||:|.|
  Rat   320 AASISWLLYCLALNPEHQDRCRTEIRSILGDG--SSITWEQLDEIPYTTMCIKETLRLIPPIPSI 382

  Fly   382 GRWFAEDVEIRGKH-IPAGTNFTMGIFVLLRDPEYFESPDEFRPERFDAD-VPQIHPYAYIPFSA 444
            .|..::.:.:...| :|||....:.|:.|..:|..::.|..|.|.||..: ..|.||.|::|||:
  Rat   383 SRELSKPLTLPDGHSLPAGMTVVLSIWGLHHNPAVWKDPKVFDPLRFTKENSEQRHPCAFLPFSS 447

  Fly   445 GPRNCIGQKFAMLEMKSTVSKLLRHFEL-LPLGPEPRHSMNIVLRSANGVHLGLK 498
            ||||||||:|||||:|..::..|..|.: ..|...|..|.:.|||..:|::|.||
  Rat   448 GPRNCIGQQFAMLELKVAIALTLLRFRVAADLTRPPAFSSHTVLRPKHGIYLHLK 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d2	NP_001284806.1	p450	32..495	CDD:278495	158/475 (33%)
Cyp4x1	NP_663708.1	CYP4B-like	66..500	CDD:410771	153/451 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348514
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.750