DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d2 and Cyp4a29

DIOPT Version :9

Sequence 1:	NP_001284806.1	Gene:	Cyp4d2 / 31192	FlyBaseID:	FBgn0011576	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001093653.1	Gene:	Cyp4a29 / 230639	MGIID:	3717143	Length:	509	Species:	Mus musculus

Alignment Length:	502	Identity:	164/502 - (32%)
Similarity:	272/502 - (54%)	Gaps:	26/502 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VVGVLLLVAFATLLLWDFLWRRRGNGILPGPRPLPFLGNLLMYRGLDPE--QIMDFVKKNQRKYG 66
            ::|:|||:..|........|..|.....|.|......|:.|.:: :|.|  .|:.:::|....:
Mouse    24 LIGLLLLLFKAAQHYLRRQWLLRALYQFPSPPSHWLFGHCLQFK-VDEELRWILRYLEKFPGAF- 86

  Fly    67 RLYRVWILHQLAVFSTDPRDIEFVLSSQQHITKNNLYKLLNCWLGDGLLMSTGRKWHGRRKIITP 131
             |:.:|..| :.:...||..::.:|....  .|.:||:.|..|||.||....|.:|...|:::||
Mouse    87 -LHWIWGSH-VFIKVCDPDYMKVILGRAD--PKASLYRFLTPWLGHGLFFLNGDEWFQHRRLLTP 147

  Fly   132 TFHFKILEQFVEIFDQQSAVMVEQLQSRADGMTPINIFPVICLTALDIIAETAMGTKINAQ-KNP 195
            .||:.||:.:|.|......||:|:.:..|.....:.||..|.|..||.|.:.|...:.:.| ...
Mouse   148 AFHYDILKPYVGIMADSVQVMLEKWEQIACQDITLEIFHPISLMMLDTIMKYAFSYQGSVQLDRS 212

  Fly   196 NLPYVQAVNDVTNILIKRFIHAWQRVDWIFRLTQPTEAKRQDKAIKVMHDFTENIIRERRETLVN 260
            :..|:|||:|:.|::..|..:.:...|.|:.||  :.::|.:.|.::.|:.|:.:::.|:..|.:
Mouse   213 SQAYLQAVSDLNNLVTSRMKNVFLHNDIIYNLT--SHSRRTNSACQIAHEHTDRVVKLRKAQLQD 275

  Fly   261 NSKETTPEEEVNFLGQKRRMALLDVLLQSTI-DGAPLSDEDIREEVDTFMFEGHDTTTSAISFCL 324
            |       :.:..|..||.:..||:||.|.: ||:.|||:.:|.|||:.||.||||..|.||:..
Mouse   276 N-------KSMKKLRGKRCLDFLDILLLSRMDDGSSLSDKALRAEVDSLMFGGHDTPASGISWVF 333

  Fly   325 YEISRHPEVQQRLQQEIRDVLGEDRKSPVTLRDLGELKFMENVIKESLRLHPPVPMIGRWFAEDV 389
            |.::.||:.|||.::|::.:||:.  ||:|...|.::.:....|||:|||:||:|.:||..:..|
Mouse   334 YALATHPDHQQRCREEVQSLLGDG--SPITWDHLHQMPYTTMCIKEALRLYPPIPSVGRKLSTPV 396

  Fly   390 EI-RGKHIPAGTNFTMGIFVLLRDPEYFESPDEFRPERFDADVPQIHPYAYIPFSAGPRNCIGQK 453
            .. .|:.:|.|....:..:.|..:|:.:.:|:.|.|.||..:..| |.:|::|||.|.|||||:.
Mouse   397 TFPDGRSLPKGITVLLHFYALHHNPKVWPNPEVFDPSRFAMNSVQ-HSHAFLPFSGGSRNCIGKH 460

  Fly   454 FAMLEMKSTVSKLLRHFELLPLGPE--PRHSMNIVLRSANGVHLGLK 498
            .||..:|..|:..|..||||| .|.  |..:..:||:|.||::|.|:
Mouse   461 LAMNVLKVAVALTLLRFELLP-DPSRVPIPTQQLVLKSKNGIYLHLR 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d2	NP_001284806.1	p450	32..495	CDD:278495	155/469 (33%)
Cyp4a29	NP_001093653.1	p450	52..503	CDD:278495	155/469 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845043
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.650