DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d2 and Cyp4f17

DIOPT Version :9

Sequence 1:	NP_001284806.1	Gene:	Cyp4d2 / 31192	FlyBaseID:	FBgn0011576	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001094915.1	Gene:	Cyp4f17 / 208285	MGIID:	3646233	Length:	524	Species:	Mus musculus

Alignment Length:	526	Identity:	182/526 - (34%)
Similarity:	283/526 - (53%)	Gaps:	55/526 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLGVVGVLLLVAFATLLLW-----DFLWRRRGNGILPGPRPLP----FLGNLLMYRGLDPEQIMD 56
            :|.:||..|.:  |.:|.|     |...|.|   ..|.|   |    |.|::.|.:  :.|:.:.
Mouse    21 LLQLVGASLFL--ARILTWICAFYDNYCRLR---CFPEP---PSRHWFWGHMSMVK--NNEEGLQ 75

  Fly    57 FVKKNQRKYGRLYRVWI---------LHQLAVFSTDPRDIEFVLSSQQHITKNNL--YKLLNCWL 110
            .:.:...::..::..||         :|        |:.|..:|.:...:....:  |..|..||
Mouse    76 LLTERSHQFHDVHLCWIGPFYPILRLIH--------PKFIGPILQASAAVAPKEMIFYGFLKPWL 132

  Fly   111 GDGLLMSTGRKWHGRRKIITPTFHFKILEQFVEIFDQQSAVMVEQLQS-RADGMTPINIFPVICL 174
            |||||:|.|.||...|.::||.|||.||:.:::.|::...:|..:.|. ...|...:::...|.|
Mouse   133 GDGLLVSAGEKWSRHRHLLTPAFHFDILKPYMKNFNKSVNIMHAKWQRLTTKGTACLDMLEHISL 197

  Fly   175 TALDIIAETAMGTKINAQKNPNLPYVQAVNDVTNILIKRFIHAWQRVDWIFRLTQPTEAKRQDKA 239
            ..||.:.........|.|::|: .|:.|:.:::::::||....:..:|:::..|  .:.:|..||
Mouse   198 MTLDSLQNCVFSFDSNCQESPS-EYIAAIQELSSLIVKRHHQPFLYLDFLYYCT--ADGRRFRKA 259

  Fly   240 IKVMHDFTENIIRERRETLVNNSKETTPEEEVNFLGQKRRMALLD----VLLQSTIDGAPLSDED 300
            ..::|:||:.:|||||.||.:.:.:       .||..|.:...||    :||.....|..|||||
Mouse   260 CDLVHNFTDAVIRERRRTLSSQNLD-------EFLKSKTKSKTLDFIDVLLLAKDEHGKELSDED 317

  Fly   301 IREEVDTFMFEGHDTTTSAISFCLYEISRHPEVQQRLQQEIRDVLGEDRKSPVTLRDLGELKFME 365
            ||.|.|||||.|||||.||:|:.||.::||||.|:|.:||::::|.......:...||.:|.|:.
Mouse   318 IRAEADTFMFGGHDTTASALSWILYNLARHPEYQERCRQEVQELLRGREPQEIEWDDLAQLPFLT 382

  Fly   366 NVIKESLRLHPPVPMIGRWFAEDVEI-RGKHIPAGTNFTMGIFVLLRDPEYFESPDEFRPERFDA 429
            ..|||||||||||.:|.|...:||.: .|:.||.||:..:.||.:..:||.:..|:.:.|.|||.
Mouse   383 MCIKESLRLHPPVTVISRCCTQDVVLPDGRVIPKGTDCVISIFGVHHNPEVWPDPEVYDPFRFDP 447

  Fly   430 DVPQIH-PYAYIPFSAGPRNCIGQKFAMLEMKSTVSKLLRHFELLPLGPEPRHSMNIVLRSANGV 493
            :.||.. |.|:|||||||||||||.|||.|||..::..|..|.:||...|||....::||:..|:
Mouse   448 ENPQKRSPLAFIPFSAGPRNCIGQTFAMREMKVALALTLLRFRVLPGDKEPRRKPELILRAEGGL 512

  Fly   494 HLGLKP 499
            .|.::|
Mouse   513 WLRVEP 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d2	NP_001284806.1	p450	32..495	CDD:278495	170/484 (35%)
Cyp4f17	NP_001094915.1	p450	52..515	CDD:365848	170/485 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845154
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.650