Protein Alignment Cyp4d2 and CYP4Z1

DIOPT Version :10

• Sequence 1: NP_525043.1
• Gene: Cyp4d2 / 31192
• FlyBaseID: FBgn0011576
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_835235.1
• Gene: CYP4Z1 / 199974
• HGNCID: 20583
• Length: 505
• Species: Homo sapiens
• Alignment Length: 507
• Identity: 163/507 - (32%)
• Similarity: 264/507 - (52%)
• Gaps: 34/507 - (6%)

  Fly     7 VLLLVAFATLLLWDFL-------WRRRGNGILPGPRPLPFLGNLLMYRGLDPEQIMDFVKKNQRK 64
            :||::...:|||:..:       |..|...:.|.|....|.|:...|    |.:..:...|...|
Human    15 LLLILLCMSLLLFQVIRLYQRRRWMIRALHLFPAPPAHWFYGHKEFY----PVKEFEVYHKLMEK 75

  Fly    65 YGRLYRVWILHQLAVFSTDPRDIEFVLSSQQHITKNNLYKLLNCWLGDGLLMSTGRKWHGRRKII 129
            |.....:|:......||....|...:|..:|.......:|:|..|:|.||:...|.||...|:|:
Human    76 YPCAVPLWVGPFTMFFSVHDPDYAKILLKRQDPKSAVSHKILESWVGRGLVTLDGSKWKKHRQIV 140

  Fly   130 TPTFHFKILEQFVEIFDQQSAVMVEQLQSRADGMTPINIFPVICLTALDIIAETAMGTKINAQKN 194
            .|.|:..||:.|:.:..:...:|:.:.:......:.:.:|..:.|..||.|.:.|...:.:.|.:
Human   141 KPGFNISILKIFITMMSESVRMMLNKWEEHIAQNSRLELFQHVSLMTLDSIMKCAFSHQGSIQLD 205

  Fly   195 PNL-PYVQAV---NDVTNILIKRFIHAWQRVDWIFRLTQPTEAKRQDKAIKVMHDFTENIIRERR 255
            ..| .|::||   :.::|..:..|:|   ..|.:|:.:  ::.:...|..:.:|.|||.:|::|:
Human   206 STLDSYLKAVFNLSKISNQRMNNFLH---HNDLVFKFS--SQGQIFSKFNQELHQFTEKVIQDRK 265

  Fly   256 ETLVNNSKETTPEEEVNFLGQKRRMALLDVLLQSTIDGA-PLSDEDIREEVDTFMFEGHDTTTSA 319
            |:|.:..|:.|.        ||||...||:||.:..:.. ..|:.|::.||.||||.|||||:||
Human   266 ESLKDKLKQDTT--------QKRRWDFLDILLSAKSENTKDFSEADLQAEVKTFMFAGHDTTSSA 322

  Fly   320 ISFCLYEISRHPEVQQRLQQEIRDVLGEDRKSPVTLRDLGELKFMENVIKESLRLHPPVPMIGRW 384
            ||:.||.::::||.|||.:.|||::||:.  |.:|...|.::.:....|||.|||:.||..|.|.
Human   323 ISWILYCLAKYPEHQQRCRDEIRELLGDG--SSITWEHLSQMPYTTMCIKECLRLYAPVVNISRL 385

  Fly   385 FAEDVEI-RGKHIPAGTNFTMGIFVLLRDPEYFESPDEFRPERFDAD-VPQIHPYAYIPFSAGPR 447
            ..:.:.. .|:.:|||....:.|:.|..:|.::|.|..|.|.||..: ..:|||||:||||||.|
Human   386 LDKPITFPDGRSLPAGITVFINIWALHHNPYFWEDPQVFNPLRFSRENSEKIHPYAFIPFSAGLR 450

  Fly   448 NCIGQKFAMLEMKSTVSKLLRHFELLPLGPEPRHSM-NIVLRSANGVHLGLK 498
            |||||.||::|.|..|:..|..|:|.|....|...: .:||:|.||:|:..|
Human   451 NCIGQHFAIIECKVAVALTLLRFKLAPDHSRPPQPVRQVVLKSKNGIHVFAK 502

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d2	NP_525043.1	CYP4	66..495	CDD:410721	145/436 (33%)
CYP4Z1	NP_835235.1	CYP4B-like	66..500	CDD:410771	149/448 (33%)