DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4d2 and cyp-13A7

DIOPT Version :9

Sequence 1:	NP_001284806.1	Gene:	Cyp4d2 / 31192	FlyBaseID:	FBgn0011576	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_496114.1	Gene:	cyp-13A7 / 188362	WormBaseID:	WBGene00000372	Length:	518	Species:	Caenorhabditis elegans

Alignment Length:	560	Identity:	146/560 - (26%)
Similarity:	251/560 - (44%)	Gaps:	115/560 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLVAFAT--------LLLWDFLWRRRGNGILPGPRPLPFLGNLLMYRGLDPEQIMDFVKKNQRKY 65
            :|:|.|.        |.:|.| |.|:|   :.|||.|||||.:..:...:....:.| .:..:||
Worm     5 ILIAIAIFVGIISYYLWIWSF-WIRKG---VKGPRGLPFLGVIHKFTNYENPGALKF-SEWTKKY 64

  Fly    66 GRLYRVWILHQLAVFSTDPRDIEFVLSSQQHITKNNLY-KLLNCWLGD-------GLLMSTGRKW 122
            |.:|.:....:..:..:||..:..|...|    .:|.| :.|....||       .|:.:.|.:|
Worm    65 GPVYGITEGVEKTLVISDPEFVHEVFVKQ----FDNFYGRKLTAIQGDPNKNKRVPLVAAQGHRW 125

  Fly   123 HGRRKIITPTFHFKILEQFVEIFDQQSAVMVEQLQ-SRADGMTPINIFPVICLTALDIIAETAMG 186
            ...|.:.:|||..|.|.:.:...::....:|..|: :.|:|.| :::........:|||.:.|||
Worm   126 KRLRTLASPTFSNKSLRKIMGTVEESVTELVRSLEKASAEGKT-LDMLEYYQEFTMDIIGKMAMG 189

  Fly   187 TKINAQ-KNPNL-----------------------------------PYVQAVNDVTNILIKRFI 215
            .:.:.. :||.|                                   |.:|...|:.:||.|
Worm   190 QEKSLMFRNPMLDKVKTIFKEGRNNVFMISGIFPFVGIALRNIFAKFPSLQMATDIQSILEK--- 251

  Fly   216 HAWQRVDWIFRLTQPTEAKRQDKAIKV-----MHDFTENIIRERRETLVNNSKETTPEEEVNFL- 274
                      .|.:..|.:..|:...:     ..||.: :..:.|.|             |:|.
Worm   252 ----------ALNKRLEQREADEKAGIEPSGEPQDFID-LFLDARST-------------VDFFE 292

  Fly   275 GQ-KRRMALLDVLLQSTIDGAPLSDEDIREEVDTFMFEGHDTTTSAISFCLYEISRHPEVQQRLQ 338
            |: ::..|..:||   .:| ..|:.::|..::..|:..|:|||..::|:..|.::.|||:|::||
Worm   293 GEAEQDFAKSEVL---KVD-KHLTFDEIIGQLFVFLLAGYDTTALSLSYSSYLLATHPEIQKKLQ 353

  Fly   339 QEIRDVLGEDRKSP---VTLRDLGELKFMENVIKESLRLHPPVPMI-GRWFAEDVEIRGKHIPAG 399
            :|:      ||:.|   ||...|.:||::|.|:||:|||:|...:: .|...:...:.|..|.||
Worm   354 EEV------DRECPDPEVTFDQLSKLKYLECVVKEALRLYPLASLVHNRKCLKTTNVLGMEIEAG 412

  Fly   400 TNFTMGIFVLLRDPEYF-ESPDEFRPERFDA-DVPQIHPYAYIPFSAGPRNCIGQKFAMLEMKST 462
            ||..:..:.|..||:.: :..:||:|||::: |........|:||..|||.|||.:.||:|||..
Worm   413 TNINVDTWSLHHDPKVWGDDVNEFKPERWESGDELFFAKGGYLPFGMGPRICIGMRLAMMEMKML 477

  Fly   463 VSKLLRH--FELLPLGPEPRHSMNIVLRSANGVHLGLKPR 500
            ::.:|::  ||..|....|...:.....:.:.|.|.||.|
Worm   478 LTNILKNYTFETTPETVIPLKLVGTATIAPSSVLLKLKSR 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d2	NP_001284806.1	p450	32..495	CDD:278495	133/522 (25%)
cyp-13A7	NP_496114.1	p450	33..499	CDD:278495	132/508 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810