DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d2 and cyp-35D1

DIOPT Version :9

Sequence 1:	NP_001284806.1	Gene:	Cyp4d2 / 31192	FlyBaseID:	FBgn0011576	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_507044.1	Gene:	cyp-35D1 / 184495	WormBaseID:	WBGene00008829	Length:	499	Species:	Caenorhabditis elegans

Alignment Length:	519	Identity:	107/519 - (20%)
Similarity:	211/519 - (40%)	Gaps:	93/519 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VLLLVAFATLLLWDFLWRRRGNGIL---PGPRPLPFLGNL--LMYR-----GLDPEQIMDFVKKN 61
            ::||...|..::...|:|:    :|   |||.|||.:||.  :.|:     |:.|  .:|:.:|
Worm     3 LILLFLTAITVITVRLYRK----VLRFPPGPFPLPLIGNAHQIAYQAWRRGGILP--ALDYYRK- 60

  Fly    62 QRKYGRLYRVWILHQLAVFSTDPRDIEFVLSSQ-------------QHITKNNLYKLLNCWLGDG 113
              |||..|.:|:..:.:|..||....:.|...|             :|:|.           |.|
Worm    61 --KYGNAYTLWLGPKASVSITDFETSQEVFVKQGKKCYNRQLAPILEHVTG-----------GVG 112

  Fly   114 LLMSTGRKWHGRRKIITPTFH-----FKILEQFVEIFDQQSAVMVE---QLQSRADGMTPINIFP 170
            ||::.|..|...|:....||.     ..|:|:  .|.|:.:...:|   |:......:..:..|.
Worm   113 LLIANGENWAEMRRFTLLTFRQMGVGTNIMEK--RIMDELNGRCLEIDAQIARNDRAIVDVKFFD 175

  Fly   171 VICLTALDIIAETAMGTKINAQKNPNLPYVQAVNDVTNILIKRF---IHAWQRVDWI---FRLTQ 229
               ||...:|....:|.:...::  ....::.:.|.::.....|   :..|....::   |:||.
Worm   176 ---LTVGSVINSFLIGKRFEDEE--EFLKIKKLFDESSETFNIFDLNVPVWFLKTFLPSRFKLTW 235

  Fly   230 PTEAKRQDKAIKVMHDFTENIIRERRETLVNNSKETTPEEEVN----FLGQKRRMALLDVLLQST 290
            .:..:..|..:|.        :.||...:.:.:.:..|::..:    ||.:.::        :..
Worm   236 DSRHQIMDHVMKG--------VEERIRDIESGAYKIDPKKPNDVVDAFLSKMKK--------EEE 284

  Fly   291 IDGA--PLSD-EDIREEVDTFMFEGHDTTTSAISFCLYEISRHPEVQQRLQQEIRDVLGEDRKSP 352
            |.|.  |..: :.::..:......|..||.:.:.....::..||.:.|.:|:|:.|:. |:....
Worm   285 IAGGQHPYYNLKSLKLVLHDLWLAGQGTTATTLYVGFMKLVNHPGIIQNIQKELLDIT-ENGARD 348

  Fly   353 VTLRDLGELKFMENVIKESLRLHPPVPMIGRWFA--EDVEIRGKHIPAGTNFTMGIFVLLRDPEY 415
            :||:|.....::...|.| ::.|..:..:..|..  |.:......:..||.....:.||..:.|.
Worm   349 LTLKDRPNTPYLNATIAE-IQRHASILNVNFWRINHETIHFNDYQVDPGTMIAAQVGVLHVNEEL 412

  Fly   416 FESPDEFRPERFDADVPQIHPYAYIPFSAGPRNCIGQKFAMLEMKSTVSKLLRHFELLPLGPEP 479
            |::|.:|..|::..: |::.... |||..|.|:|:|::.|..|:......:|..:.:...|..|
Worm   413 FDNPKDFNVEKYLKN-PKLLQQV-IPFGIGKRSCVGEQIAKSELYLVFGNILLRYNVKKHGSTP 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d2	NP_001284806.1	p450	32..495	CDD:278495	101/491 (21%)
cyp-35D1	NP_507044.1	p450	35..496	CDD:299894	95/483 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010