Protein Alignment Cyp4d2 and cyp-25A4

DIOPT Version :10

• Sequence 1: NP_525043.1
• Gene: Cyp4d2 / 31192
• FlyBaseID: FBgn0011576
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_497779.1
• Gene: cyp-25A4 / 183248
• WormBaseID: WBGene00007967
• Length: 501
• Species: Caenorhabditis elegans
• Alignment Length: 525
• Identity: 134/525 - (25%)
• Similarity: 240/525 - (45%)
• Gaps: 71/525 - (13%)

  Fly    10 LVAFATLLLW--DFLWRRRGNGILPGPRPLPFL-GNLLMYRGLDPEQIMDFVKKNQ------RKY 65
            ::.|.:..:|  ..:::.|.:..:||| |:.:| |||.:.:  |....:.:....|      .||
 Worm    13 IITFISYSIWRRHAIFKLRSSIGIPGP-PVHWLWGNLNIIK--DRVSRLGYNDTTQWHPTLHTKY 74

  Fly    66 GRLYRVWILHQLAVFSTDPRDI-EFVLSSQQHITKNNLYKLLNC-WLGDGLLMST-GRKWHGRRK 127
            |.::.::...||.:..::..|| |..:.:..:.:......:... .|...||.:| ...|...|.
 Worm    75 GPIFGLYCGTQLHITVSEEEDIKEIFIQNFSNFSDRMTPDIFGMNQLNQSLLQNTYATGWKHTRS 139

  Fly   128 IITPTFHFKILEQFVEIFDQQSAVMVEQLQSRADGMTPINIFPVICLTALDIIAETAMGTKINAQ 192
            .|.|.|....::...|....:..:.:|.|:.::......:||......:||||.:.|.....|.|
 Worm   140 AIAPIFSTGKMKAMHETLVSKIDIFLEVLKEKSSSGQKWDIFENFQSLSLDIIGKCAFAIDSNCQ 204

  Fly   193 KN-PNLPYVQAVNDVTNILIKRFIHAW--------QRVDWIFRLTQPTEAKRQDKA------IKV 242
            :: .:|.||||...|..:.:|:   :|        ..:.|::|...    |..|.:      :|.
 Worm   205 RDRTDLFYVQARKFVGAVDLKK---SWILPVSLILPELSWLWRFLY----KFSDLSAAELPLVKG 262

  Fly   243 MHDFTENIIRERRETLVNNSKETTPEEEVNFLGQKRRMALLDVLLQSTIDGAPLSDEDIREEVDT 307
            :.|..:   |.|.....|:|.:                 ||::|::....| .::..::.|....
 Worm   263 LVDLYD---RRRAGEGGNDSTD-----------------LLNLLIRRETIG-KMTQREVIENCFA 306

  Fly   308 FMFEGHDTTTSAISFCLYEISRHPEVQQRLQQEIRDVLGEDRKSPVTLRDLGELKFMENVIKESL 372
            |:..|::||::|:.|..|.::.:|.|||:|.:||:..   ...:.:....:..:|:::.|.||||
 Worm   307 FLIAGYETTSTAMMFSAYLLAEYPIVQQKLYEEIKKT---KENAGLNYDSIHNMKYLDCVYKESL 368

  Fly   373 RLHPPVP-MIGRWFAEDVEIRGKHIPAGTNFTMGIFVLLRDPEYFESPDEFRPERFDADVPQIHP 436
            |.:||.. ...|....|:.|||:..|..:...:..:.:.|:|..:||||||:||||:....:...
 Worm   369 RFYPPTTHFTNRVCLNDMTIRGQIYPEDSTLKVQPYTIHRNPANWESPDEFQPERFENWEEKSSS 433

  Fly   437 YAYIPFSAGPRNCIGQKFAMLEMKSTVSKLLRHFELL------PLGPEPRHSMNIVLRSANGVHL 495
            ..:|||..|||.|:|.:||.:|.|:|::|||..|||.      |:.||   :..::.|..:.|.|
 Worm   434 LKWIPFGVGPRYCVGMRFAEMEFKTTIAKLLDTFELSLVPGDPPMIPE---TNGVIFRPRSPVRL 495

  Fly   496 GLKPR 500
            .||.|
 Worm   496 NLKLR 500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d2	NP_525043.1	CYP4	66..495	CDD:410721	115/453 (25%)
cyp-25A4	NP_497779.1	CYP3A-like	73..494	CDD:410678	116/454 (26%)