Protein Alignment Cyp4d2 and Cyp3a9

DIOPT Version :10

• Sequence 1: NP_525043.1
• Gene: Cyp4d2 / 31192
• FlyBaseID: FBgn0011576
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_671739.2
• Gene: Cyp3a9 / 171352
• RGDID: 708392
• Length: 503
• Species: Rattus norvegicus
• Alignment Length: 522
• Identity: 157/522 - (30%)
• Similarity: 258/522 - (49%)
• Gaps: 69/522 - (13%)

  Fly     8 LLLVAFATLLLWDFLWRRRGNGI-----LPGPRPLPFLGNLLMYRGLDPEQIMDFVKKNQRKYGR 67
            ||||....||   :|:....:||     :|||:||||||.:|.||    :...:|.|...:|||:
  Rat    13 LLLVISLVLL---YLYGTHSHGIFKKLGIPGPKPLPFLGTILAYR----KGFWEFDKYCHKKYGK 70

  Fly    68 LYRVWILHQLAVFSTDPRDIEFVLSSQQHITKNN---------LYKLLNCWLGDGLLMSTGRKWH 123
            |:.::...|..:..|||..|:.||..:.:.|..|         |.|.::        :|...:|.
  Rat    71 LWGLYDGRQPVLAITDPDIIKTVLVKECYSTFTNRRNFGPVGILKKAIS--------ISEDEEWK 127

  Fly   124 GRRKIITPTFHFKILEQFVEIFDQQSAVMVEQLQSRADGMTPINIFPVICLTALDIIAETAMGTK 188
            ..|.:::|||....|::...|.:|.:.::|..::..::...|.::..:....::|:|..|:.|..
  Rat   128 RIRALLSPTFTSGKLKEMFPIINQYTDMLVRNMRQGSEEGKPTSMKDIFGAYSMDVITATSFGVN 192

  Fly   189 INAQKNPNLPYVQAVNDVTNILIKRFIHAWQRVDWIFRLTQPTEAKRQDKAIKVMHDFTENIIRE 253
            :::..||..|:|:.:..:....|  |...:..|.....||...||.......:.:.||.:..:..
  Rat   193 VDSLNNPQDPFVEKIKKLLKFDI--FDPLFLSVTLFPFLTPLFEALNVSMFPRDVIDFFKTSVER 255

  Fly   254 RRETLVNNSKETTPEEEVNFLGQKRRMALLDVLLQSTIDGA-----PLSDEDIREEVDTFMFEGH 313
            .:|   |..||.          :|:||..|.:::.|.....     .|||.:|..:...|:|.|:
  Rat   256 MKE---NRMKEK----------EKQRMDFLQLMINSQNSKVKDSHKALSDVEIVAQSVIFIFAGY 307

  Fly   314 DTTTSAISFCLYEISRHPEVQQRLQQEIRDVLGEDRKSPVTLRDLGELKFMENVIKESLRLHPPV 378
            :||:||:||.||.::.||::|::||.||...|  ..|:..|...|.::::::.|:.|:|||:|..
  Rat   308 ETTSSALSFVLYLLAIHPDIQKKLQDEIDAAL--PNKAHATYDTLLQMEYLDMVVNETLRLYPIA 370

  Fly   379 PMIGRWFAEDVEIRGKHIPAGTNFTMGIFVLLRDPEYFESPDEFRPERFD-ADVPQIHPYAYIPF 442
            ..:.|....||||.|..||.||...:..|.|.:||.|:..|:|||||||. .:...|:||.|:||
  Rat   371 GRLERVCKTDVEINGVFIPKGTVVMIPTFALHKDPHYWPEPEEFRPERFSKKNQDNINPYMYLPF 435

  Fly   443 SAGPRNCIGQKFAMLEMKSTVSKLLRHFELLP---------------LGPEPRHSMNIVLR--SA 490
            ..|||||||.:||::.||..:.::|::|...|               |.||....:.:|.|  :.
  Rat   436 GNGPRNCIGMRFALMNMKVALVRVLQNFSFQPCKETQIPLKLSKQGLLQPEKPLLLKVVSRDETV 500

  Fly   491 NG 492
            ||
  Rat   501 NG 502

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d2	NP_525043.1	CYP4	66..495	CDD:410721	132/459 (29%)
Cyp3a9	NP_671739.2	CYP3A	67..492	CDD:410743	130/449 (29%)