Protein Alignment Cyp4d2 and Cyp3a62

DIOPT Version :10

• Sequence 1: NP_525043.1
• Gene: Cyp4d2 / 31192
• FlyBaseID: FBgn0011576
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_001019403.1
• Gene: Cyp3a62 / 170509
• RGDID: 1595919
• Length: 497
• Species: Rattus norvegicus
• Alignment Length: 483
• Identity: 153/483 - (31%)
• Similarity: 254/483 - (52%)
• Gaps: 53/483 - (10%)

  Fly     9 LLVAFATLLLWDFLWRRRGN----GILPGPRPLPFLGNLLMYRGLDPEQIMDFVKKNQRKYGRLY 69
            :|:|...:||:.:.....||    || .||:||||:||:|.||    ....:|.:...:|||.::
  Rat    13 MLLATILVLLYLYGTSTHGNFKKLGI-SGPKPLPFVGNILAYR----HGFWEFDRHCHKKYGDIW 72

  Fly    70 RVWILHQLAVFSTDPRDIEFVLSSQQHITKNN---------LYKLLNCWLGDGLLMSTGRKWHGR 125
            ..:...|..:..|||..|:.||..:.:.|..|         |.|        .:.:|...:|...
  Rat    73 GFYEGRQPILAITDPDIIKTVLVKECYSTFTNRRSFGPAGILKK--------AITLSEDEEWKRL 129

  Fly   126 RKIITPTFHFKILEQFVEIFDQQSAVMVEQLQSRADGMTPINIFPVICLTALDIIAETAMGTKIN 190
            |.:::|||....|::...|.:|.:.::|:.::..|:...||.:..:....::|:|..|:.|..::
  Rat   130 RTLLSPTFTSGKLKEMFPIINQYADLLVKNVKHEAEKGNPITMKDIFGAYSMDVITGTSFGVNVD 194

  Fly   191 AQKNPNLPYVQAVNDVT--NILIKRFIHAWQRVDWIFRLTQPTEAKRQDKAIKVMHDFTENIIRE 253
            :..||..|:||.|..:.  |.|...|:..   :.:.| ||...||  .|..:     |.:::::.
  Rat   195 SLNNPQNPFVQKVKKLLKFNFLDPFFLSV---ILFPF-LTPVFEA--FDITV-----FPKDVMKF 248

  Fly   254 RRETLVNNSKETTPEEEVNFLGQKRRMALLDVLLQSTIDG-----APLSDEDIREEVDTFMFEGH 313
            .| |.|...||...:|:|     |:|:..|.:::.|...|     ..|:|.:|..:...|:|.|:
  Rat   249 FR-TSVERMKENRMQEKV-----KQRLDFLQLMINSQSSGDKESHQGLTDVEIVAQSIFFIFAGY 307

  Fly   314 DTTTSAISFCLYEISRHPEVQQRLQQEIRDVLGEDRKSPVTLRDLGELKFMENVIKESLRLHPPV 378
            :||:||:||.||.::.||::|::||.||...|  ..|:|||...|.|:::::.|:.|:|||.|..
  Rat   308 ETTSSALSFALYLLATHPDLQKKLQDEIDAAL--PNKAPVTYDVLVEMEYLDMVLNETLRLFPVG 370

  Fly   379 PMIGRWFAEDVEIRGKHIPAGTNFTMGIFVLLRDPEYFESPDEFRPERF-DADVPQIHPYAYIPF 442
            ..:.|...:||||.|..||.||...:..|.|.:||:.:..|:||.|||| ..:...|:||.|:||
  Rat   371 GRLERVCKKDVEINGVFIPKGTVVMVPTFALHKDPKCWPEPEEFCPERFRKKNQDSINPYIYLPF 435

  Fly   443 SAGPRNCIGQKFAMLEMKSTVSKLLRHF 470
            ..|||||||.:||::.||..:.::|::|
  Rat   436 GNGPRNCIGMRFALMNMKIALVRVLQNF 463

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d2	NP_525043.1	CYP4	66..495	CDD:410721	131/422 (31%)
Cyp3a62	NP_001019403.1	CYP3A	67..492	CDD:410743	133/424 (31%)