DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d2 and Cyp3a62

DIOPT Version :9

Sequence 1:	NP_001284806.1	Gene:	Cyp4d2 / 31192	FlyBaseID:	FBgn0011576	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001019403.1	Gene:	Cyp3a62 / 170509	RGDID:	1595919	Length:	497	Species:	Rattus norvegicus

Alignment Length:	483	Identity:	153/483 - (31%)
Similarity:	254/483 - (52%)	Gaps:	53/483 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLVAFATLLLWDFLWRRRGN----GILPGPRPLPFLGNLLMYRGLDPEQIMDFVKKNQRKYGRLY 69
            :|:|...:||:.:.....||    || .||:||||:||:|.||    ....:|.:...:|||.::
  Rat    13 MLLATILVLLYLYGTSTHGNFKKLGI-SGPKPLPFVGNILAYR----HGFWEFDRHCHKKYGDIW 72

  Fly    70 RVWILHQLAVFSTDPRDIEFVLSSQQHITKNN---------LYKLLNCWLGDGLLMSTGRKWHGR 125
            ..:...|..:..|||..|:.||..:.:.|..|         |.|        .:.:|...:|...
  Rat    73 GFYEGRQPILAITDPDIIKTVLVKECYSTFTNRRSFGPAGILKK--------AITLSEDEEWKRL 129

  Fly   126 RKIITPTFHFKILEQFVEIFDQQSAVMVEQLQSRADGMTPINIFPVICLTALDIIAETAMGTKIN 190
            |.:::|||....|::...|.:|.:.::|:.::..|:...||.:..:....::|:|..|:.|..::
  Rat   130 RTLLSPTFTSGKLKEMFPIINQYADLLVKNVKHEAEKGNPITMKDIFGAYSMDVITGTSFGVNVD 194

  Fly   191 AQKNPNLPYVQAVNDVT--NILIKRFIHAWQRVDWIFRLTQPTEAKRQDKAIKVMHDFTENIIRE 253
            :..||..|:||.|..:.  |.|...|:..   :.:.| ||...||  .|..:     |.:::::.
  Rat   195 SLNNPQNPFVQKVKKLLKFNFLDPFFLSV---ILFPF-LTPVFEA--FDITV-----FPKDVMKF 248

  Fly   254 RRETLVNNSKETTPEEEVNFLGQKRRMALLDVLLQSTIDG-----APLSDEDIREEVDTFMFEGH 313
            .| |.|...||...:|:|     |:|:..|.:::.|...|     ..|:|.:|..:...|:|.|:
  Rat   249 FR-TSVERMKENRMQEKV-----KQRLDFLQLMINSQSSGDKESHQGLTDVEIVAQSIFFIFAGY 307

  Fly   314 DTTTSAISFCLYEISRHPEVQQRLQQEIRDVLGEDRKSPVTLRDLGELKFMENVIKESLRLHPPV 378
            :||:||:||.||.::.||::|::||.||...|  ..|:|||...|.|:::::.|:.|:|||.|..
  Rat   308 ETTSSALSFALYLLATHPDLQKKLQDEIDAAL--PNKAPVTYDVLVEMEYLDMVLNETLRLFPVG 370

  Fly   379 PMIGRWFAEDVEIRGKHIPAGTNFTMGIFVLLRDPEYFESPDEFRPERF-DADVPQIHPYAYIPF 442
            ..:.|...:||||.|..||.||...:..|.|.:||:.:..|:||.|||| ..:...|:||.|:||
  Rat   371 GRLERVCKKDVEINGVFIPKGTVVMVPTFALHKDPKCWPEPEEFCPERFRKKNQDSINPYIYLPF 435

  Fly   443 SAGPRNCIGQKFAMLEMKSTVSKLLRHF 470
            ..|||||||.:||::.||..:.::|::|
  Rat   436 GNGPRNCIGMRFALMNMKIALVRVLQNF 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d2	NP_001284806.1	p450	32..495	CDD:278495	145/456 (32%)
Cyp3a62	NP_001019403.1	p450	39..491	CDD:278495	145/456 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810