Protein Alignment Cyp4d2 and CYP51A1

DIOPT Version :10

• Sequence 1: NP_525043.1
• Gene: Cyp4d2 / 31192
• FlyBaseID: FBgn0011576
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_000777.1
• Gene: CYP51A1 / 1595
• HGNCID: 2649
• Length: 509
• Species: Homo sapiens
• Alignment Length: 498
• Identity: 119/498 - (23%)
• Similarity: 218/498 - (43%)
• Gaps: 89/498 - (17%)

  Fly     8 LLLVAFATLLLWDFLWRRRGNGILPGP----------RPLPFLGNLLMYRGLDPEQIMDFVKKNQ 62
            :||:|.|..|...:|.|.....::..|          .|:||||:.:.: |..|   ::|::...
Human    35 MLLIACAFTLSLVYLIRLAAGHLVQLPAGVKSPPYIFSPIPFLGHAIAF-GKSP---IEFLENAY 95

  Fly    63 RKYGRLYRVWILHQLAVF--STDPRDIEFVLSSQQHITKNNLY-KLLNCWLGDGLLMSTGRKWHG 124
            .|||.::...::.:...:  .:|...:.| .|..:.:...::| :|.....|.|:...
Human    96 EKYGPVFSFTMVGKTFTYLLGSDAAALLF-NSKNEDLNAEDVYSRLTTPVFGKGVAYD------- 152

  Fly   125 RRKIITPTF--------------HFKILEQFVEIFDQQSAVMVEQLQSRADGMTPINIF----PV 171
               :..|.|              |||   |.|.|.::::....|......:.    |:|    .:
Human   153 ---VPNPVFLEQKKMLKSGLNIAHFK---QHVSIIEKETKEYFESWGESGEK----NVFEALSEL 207

  Fly   172 ICLTALDIIAETAMGTKINAQKNPNLPYVQAVNDVTNILIKRFIH-AWQRVDWIFRLTQPTEAKR 235
            |.|||    :....|.:|.:|.|..:..:.|..|      ..|.| ||....|   |..|: .:|
Human   208 IILTA----SHCLHGKEIRSQLNEKVAQLYADLD------GGFSHAAWLLPGW---LPLPS-FRR 258

  Fly   236 QDKAIKVMHDFTENIIRERRETLVNNSKETTPEEEVNFLGQKRRMALLDVLLQSTI-DGAPLSDE 299
            :|:|.:.:.|.....|::||::          :|:::        .:|..||.:|. ||.||:|:
Human   259 RDRAHREIKDIFYKAIQKRRQS----------QEKID--------DILQTLLDATYKDGRPLTDD 305

  Fly   300 DIREEVDTFMFEGHDTTTSAISFCLYEISRHPEVQQRLQQEIRDVLGEDRKSPVTLRDLGELKFM 364
            ::...:...:..|..|:::..::..:.::|...:|::...|.:.|.||: ..|:|...|.:|..:
Human   306 EVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGEN-LPPLTYDQLKDLNLL 369

  Fly   365 ENVIKESLRLHPPVPMIGRWFAEDVEIRGKHIPAGTNFTMGIFVLLRDPEYFESPDEFRPERFDA 429
            :..|||:|||.||:.::.|.......:.|..||.|....:...|..|..:.:....:|.|:|:..
Human   370 DRCIKETLRLRPPIMIMMRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQ 434

  Fly   430 DVPQI-HPYAYIPFSAGPRNCIGQKFAMLEMKSTVSKLLRHFE 471
            |.|.. ..:||:||.||...|||:.||.:::|:..|.:||.:|
Human   435 DNPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYE 477

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d2	NP_525043.1	CYP4	66..495	CDD:410721	101/430 (23%)
CYP51A1	NP_000777.1	CYP51-like	94..505	CDD:410668	103/435 (24%)