Protein Alignment Cyp4d2 and CYP24A1

DIOPT Version :10

• Sequence 1: NP_525043.1
• Gene: Cyp4d2 / 31192
• FlyBaseID: FBgn0011576
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_000773.2
• Gene: CYP24A1 / 1591
• HGNCID: 2602
• Length: 514
• Species: Homo sapiens
• Alignment Length: 486
• Identity: 125/486 - (25%)
• Similarity: 226/486 - (46%)
• Gaps: 71/486 - (14%)

  Fly    31 LPGPRPLPFLGNLL--MYRGLDPEQIMDFVKKNQRKYGRLYRVWILHQLAVFSTDPRDIEFVLSS 93
            ||||...|.||:||  :::|...:| .|.:.:..:|||:::|:.:....:|....|..:|.:..:
Human    58 LPGPTSWPLLGSLLQILWKGGLKKQ-HDTLVEYHKKYGKIFRMKLGSFESVHLGSPCLLEALYRT 121

  Fly    94 QQHITKNNLYKLLNCWL-----GDGLLMSTGRKWHG-----RRKIITPTFHFK-------ILEQF 141
            :....:....|....:.     |.|||:..|..|..     ::|::.|....|       :|..|
Human   122 ESAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEVMKLDNKINEVLADF 186

  Fly   142 V----EIFDQQSAVMVEQLQSRADGMTPINIFPVICLTALDIIAETAMGTKINAQKNPNLPYVQA 202
            :    |:.|::.  .||.|.|..:..:    |..|||    ::.|...|.   .|||..   .:|
Human   187 MGRIDELCDERG--HVEDLYSELNKWS----FESICL----VLYEKRFGL---LQKNAG---DEA 235

  Fly   203 VNDVTNILIKRFIHAWQRVDWIFRLTQPTEAKRQDKAIKVMHDFT---ENIIRERRETLVNNSKE 264
            ||.:  :.||..:..:.|:     :..|.|..:.... ||..|.|   :.|.:..:..:.|..::
Human   236 VNFI--MAIKTMMSTFGRM-----MVTPVELHKSLNT-KVWQDHTLAWDTIFKSVKACIDNRLEK 292

  Fly   265 TTPEEEVNFLGQKRRMALLDVLLQSTIDGAPLSDEDIREEVDTFMFEGHDTTTSAISFCLYEISR 329
            .:.:...:|        |.|:..|:.     ||.:::...|........:||.:::.:.||.:||
Human   293 YSQQPSADF--------LCDIYHQNR-----LSKKELYAAVTELQLAAVETTANSLMWILYNLSR 344

  Fly   330 HPEVQQRLQQEIRDVLGEDRKSPVTLRDLGELKFMENVIKESLRLHPPVPMIGRWFAEDVEIRGK 394
            :|:|||:|.:||:.||.|::..  ...||..:.:::..:|||:||.|.||...|.. :...:.|:
Human   345 NPQVQQKLLKEIQSVLPENQVP--RAEDLRNMPYLKACLKESMRLTPSVPFTTRTL-DKATVLGE 406

  Fly   395 H-IPAGTNFTMGIFVLLRDPEYFESPDEFRPERFDADVPQIHPYAYIPFSAGPRNCIGQKFAMLE 458
            : :|.||...:...||....:.||...:|||||:..:..:|:|:|::||..|.|.|||::.|.|:
Human   407 YALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQEKEKINPFAHLPFGVGKRMCIGRRLAELQ 471

  Fly   459 MKSTVSKLLRHFELLPLGPEP---RHSMNIV 486
            :...:..::|.:::.....||   .||..:|
Human   472 LHLALCWIVRKYDIQATDNEPVEMLHSGTLV 502

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d2	NP_525043.1	CYP4	66..495	CDD:410721	111/449 (25%)
CYP24A1	NP_000773.2	CYP24A1	90..508	CDD:410738	113/453 (25%)