Protein Alignment Cyp4d2 and CYP4B1

DIOPT Version :10

• Sequence 1: NP_525043.1
• Gene: Cyp4d2 / 31192
• FlyBaseID: FBgn0011576
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_001093242.1
• Gene: CYP4B1 / 1580
• HGNCID: 2644
• Length: 512
• Species: Homo sapiens
• Alignment Length: 507
• Identity: 171/507 - (33%)
• Similarity: 272/507 - (53%)
• Gaps: 33/507 - (6%)

  Fly     6 GVLLLVAFATLLLWDFLWRR----RGNGILPGPRPLPFLGNLLMYRGLDPEQIMDFVKKNQRKYG 66
            |::|::.|..|:  ..|.||    :.....|||......|:.|   .:.....:|.|.....::.
Human    19 GLILVLGFLKLI--HLLLRRQTLAKAMDKFPGPPTHWLFGHAL---EIQETGSLDKVVSWAHQFP 78

  Fly    67 RLYRVWILHQLAVFSTDPRDIEFVLSSQQHITKNNLYKLLNCWLGDGLLMSTGRKWHGRRKIITP 131
            ..:.:|....:...:....|....:.|:......::|.....|:|.|||:..|.||...||::||
Human    79 YAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPDVYDFFLQWIGRGLLVLEGPKWLQHRKLLTP 143

  Fly   132 TFHFKILEQFVEIFDQQSAVMVEQLQSRADGMTPINIFPVICLTALDIIAETAMG---TKINAQK 193
            .||:.:|:.:|.:|.:.:.:|:::.:.:|......:||..:...||:.:.:...|   |.:...:
Human   144 GFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFCDVGHMALNTLMKCTFGRGDTGLGHSR 208

  Fly   194 NPNLPYVQAVNDVTNILIKRFIHAWQRVDWIFRLTQPTEAKRQDKAIKVMHDFTENIIRERRETL 258
            :.:  |..||:|:|.::.:|.:......|:|:.||  ...:|..:|.:|.||.|:.:||||:..|
Human   209 DSS--YYLAVSDLTLLMQQRLVSFQYHNDFIYWLT--PHGRRFLRACQVAHDHTDQVIRERKAAL 269

  Fly   259 VNNSKETTPEEEVNFLGQKRR-MALLDVLLQS-TIDGAPLSDEDIREEVDTFMFEGHDTTTSAIS 321
                    .:|:|....|.|| :..||:||.: ..|...|||.|:|.|||||||||||||||.||
Human   270 --------QDEKVRKKIQNRRHLDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGIS 326

  Fly   322 FCLYEISRHPEVQQRLQQEIRDVLGEDRKSPVTLRDLGELKFMENVIKESLRLHPPVPMIGRWFA 386
            :.||.::.:||.|.|.::|:|::||:  :......|||::.::...||||.||:||||.:.|..:
Human   327 WFLYCMALYPEHQHRCREEVREILGD--QDFFQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLS 389

  Fly   387 EDVE-IRGKHIPAGTNFTMGIFVLLRDPEYFESPDEFRPERFDAD-VPQIHPYAYIPFSAGPRNC 449
            :.|. :.|:.:|||:..:|.|:.|.|:...:..|:.|...||..: ..:.||:|::|||||||||
Human   390 KPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNC 454

  Fly   450 IGQKFAMLEMKSTVSKLLRHFELLPLGPE--PRHSMNIVLRSANGVHLGLKP 499
            |||:|||.|||...:..|..|| ..|.|.  |.....:||||.||.||.|||
Human   455 IGQQFAMSEMKVVTAMCLLRFE-FSLDPSRLPIKMPQLVLRSKNGFHLHLKP 505

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d2	NP_525043.1	CYP4	66..495	CDD:410721	152/437 (35%)
CYP4B1	NP_001093242.1	CYP4B-like	67..502	CDD:410771	155/449 (35%)